ZG5_XENLA
ID ZG5_XENLA Reviewed; 445 AA.
AC P18725;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 2.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Gastrula zinc finger protein 5-1;
DE AltName: Full=XlCGF5.1;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Embryo, and Oocyte;
RX PubMed=7509444; DOI=10.1007/bf01674431;
RA Koester M., Hille S., Pieler T., Knoechel W.;
RT "Gene structure and alternative splicing of XFG 5-1, a X. laevis Zn finger
RT protein with RNA homopolymer binding activity.";
RL Mol. Biol. Rep. 18:197-207(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Embryo, and Oocyte;
RX PubMed=7506934;
RA Klocke B., Koester M., Hille S., Bouwmeester T., Boehm S., Pieler T.,
RA Knoechel W.;
RT "The FAR domain defines a new Xenopus laevis zinc finger protein subfamily
RT with specific RNA homopolymer binding activity.";
RL Biochim. Biophys. Acta 1217:81-89(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE (ISOFORM 5-1A).
RX PubMed=1717260; DOI=10.1002/j.1460-2075.1991.tb07861.x;
RA Koster M., Kuhn U., Bouwmeester T., Nietfeld W., el-Baradi T., Knochel W.,
RA Pieler T.;
RT "Structure, expression and in vitro functional characterization of a novel
RT RNA binding zinc finger protein from Xenopus.";
RL EMBO J. 10:3087-3093(1991).
RN [4]
RP NUCLEOTIDE SEQUENCE OF 234-439.
RX PubMed=2509712; DOI=10.1016/0022-2836(89)90155-1;
RA Nietfeld W., El-Baradi T., Mentzel H., Pieler T., Koester M., Poeting A.,
RA Knoechel W.;
RT "Second-order repeats in Xenopus laevis finger proteins.";
RL J. Mol. Biol. 208:639-659(1989).
CC -!- FUNCTION: Binds to RNA homomers.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=5-1B;
CC IsoId=P18725-1; Sequence=Displayed;
CC Name=5-1;
CC IsoId=P18725-3; Sequence=Not described;
CC Name=5-1A;
CC IsoId=P18725-2; Sequence=VSP_006933;
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DR EMBL; X71067; CAA50391.1; -; Genomic_DNA.
DR EMBL; X71067; CAA50390.1; -; Genomic_DNA.
DR EMBL; X70677; CAA50013.1; -; mRNA.
DR PIR; I51700; S32036.
DR RefSeq; NP_001094395.1; NM_001100925.1.
DR AlphaFoldDB; P18725; -.
DR SMR; P18725; -.
DR GeneID; 397956; -.
DR KEGG; xla:397956; -.
DR CTD; 397956; -.
DR OrthoDB; 1318335at2759; -.
DR Proteomes; UP000186698; Chromosome 6L.
DR Bgee; 397956; Expressed in oocyte and 19 other tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 7.
DR SMART; SM00355; ZnF_C2H2; 8.
DR SUPFAM; SSF57667; SSF57667; 4.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 8.
PE 2: Evidence at transcript level;
KW Alternative splicing; Metal-binding; Phosphoprotein; Reference proteome;
KW Repeat; RNA-binding; Zinc; Zinc-finger.
FT CHAIN 1..445
FT /note="Gastrula zinc finger protein 5-1"
FT /id="PRO_0000047782"
FT ZN_FING 185..210
FT /note="C2H2-type 1; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 239..261
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 267..289
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 295..317
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 323..345
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 351..373
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 379..401
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 407..429
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 89
FT /note="Phosphoserine; by CK2"
FT /evidence="ECO:0000255"
FT VAR_SEQ 107..131
FT /note="Missing (in isoform 5-1A)"
FT /evidence="ECO:0000305"
FT /id="VSP_006933"
FT VARIANT 76
FT /note="E -> D (in 5-1)"
FT VARIANT 103
FT /note="F -> S (in 5-1)"
FT VARIANT 195
FT /note="A -> S (in 5-1)"
FT CONFLICT 314
FT /note="M -> V (in Ref. 4)"
FT /evidence="ECO:0000305"
FT CONFLICT 415
FT /note="C -> L (in Ref. 4)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 445 AA; 49530 MW; 91282D3075EE76A3 CRC64;
MLQIKTEKEE LDCGDDQNPK ESSAVPLTDG ASPEPQPQIL QIKIKEEEPD YEYYLPTIKR
EMDPVPGAAS PLAESEILQI KIKEEEPDSE DDGNSAATSA VTFRDWDNCW SDEENWDDSR
PQLNQYNSDF PGSADTANTP AINTVLSRGN GLFVVNQEKR VATNSSCQSD TGHVDCSVGS
EPSGFICCKC GDSFAHHSDL HTHLYACAGH NITSSFTNAS EEGQHSHKNG GVLPREKPFK
CTVCGKCFTL KNSLQLHHRI HTGEKPFTCT ECGKSFAQSC SLQLHSRTHT GYNPYVCTEC
GKRFSSNSGL RRHMRTHTGV KPYACKECGK FFSDLSTLHR HQNSHKGEKP FICTECGKGF
TLKDSLHRHQ RTHTGEKPFI CSQCGKSYSQ SSNLIKHQMI HTGVKPFSCS ECGKCFAVKD
GLRNHQRVHM RRNYSAAQNV AEFSL
