ZGLP1_HUMAN
ID ZGLP1_HUMAN Reviewed; 271 AA.
AC P0C6A0;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=GATA-type zinc finger protein 1 {ECO:0000305};
DE AltName: Full=GATA-like protein 1 {ECO:0000250|UniProtKB:Q1WG82};
DE Short=GLP-1 {ECO:0000250|UniProtKB:Q1WG82};
GN Name=ZGLP1 {ECO:0000312|HGNC:HGNC:37245};
GN Synonyms=GLP1 {ECO:0000250|UniProtKB:Q1WG82};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Prostate;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Fetal brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Transcriptional regulator that plays a key role in germ cell
CC development. Determines the oogenic fate by activating key genes for
CC the oogenic program and meiotic prophase entry. Acts downstream of bone
CC morphogenetic protein (BMP) by regulating expression of genes required
CC for the oogenic programs, which are repressed by Polycomb activities in
CC sexually uncommitted germ cells. Regulates expression of STRA8, a
CC central downstream effector for the meiotic program. Acts independently
CC of retinoic acid (RA). In males, not required for germ-cell sex
CC determination, but required to allow the spermatogonia to efficiently
CC accomplish the meiotic prophase. {ECO:0000250|UniProtKB:Q1WG82}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q1WG82}.
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DR EMBL; AK096830; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AC011511; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC044225; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS45959.1; -.
DR RefSeq; NP_001096637.1; NM_001103167.1.
DR AlphaFoldDB; P0C6A0; -.
DR STRING; 9606.ENSP00000384434; -.
DR iPTMnet; P0C6A0; -.
DR PhosphoSitePlus; P0C6A0; -.
DR BioMuta; ZGLP1; -.
DR DMDM; 166990464; -.
DR MassIVE; P0C6A0; -.
DR PaxDb; P0C6A0; -.
DR PeptideAtlas; P0C6A0; -.
DR PRIDE; P0C6A0; -.
DR ProteomicsDB; 52325; -.
DR Antibodypedia; 42858; 100 antibodies from 20 providers.
DR DNASU; 100125288; -.
DR Ensembl; ENST00000403903.7; ENSP00000384434.3; ENSG00000220201.7.
DR GeneID; 100125288; -.
DR KEGG; hsa:100125288; -.
DR UCSC; uc002mnw.5; human.
DR CTD; 100125288; -.
DR DisGeNET; 100125288; -.
DR GeneCards; ZGLP1; -.
DR HGNC; HGNC:37245; ZGLP1.
DR HPA; ENSG00000220201; Low tissue specificity.
DR MIM; 611639; gene.
DR neXtProt; NX_P0C6A0; -.
DR OpenTargets; ENSG00000220201; -.
DR PharmGKB; PA165394820; -.
DR VEuPathDB; HostDB:ENSG00000220201; -.
DR eggNOG; KOG1601; Eukaryota.
DR GeneTree; ENSGT00470000042444; -.
DR InParanoid; P0C6A0; -.
DR OMA; GPCWELM; -.
DR OrthoDB; 1430172at2759; -.
DR PhylomeDB; P0C6A0; -.
DR PathwayCommons; P0C6A0; -.
DR SignaLink; P0C6A0; -.
DR BioGRID-ORCS; 100125288; 20 hits in 1099 CRISPR screens.
DR ChiTaRS; ZGLP1; human.
DR GenomeRNAi; 100125288; -.
DR Pharos; P0C6A0; Tdark.
DR PRO; PR:P0C6A0; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; P0C6A0; protein.
DR Bgee; ENSG00000220201; Expressed in right hemisphere of cerebellum and 92 other tissues.
DR ExpressionAtlas; P0C6A0; baseline and differential.
DR Genevisible; P0C6A0; HS.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProt.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISS:ARUK-UCL.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0048599; P:oocyte development; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007283; P:spermatogenesis; ISS:UniProtKB.
DR CDD; cd00202; ZnF_GATA; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR000679; Znf_GATA.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00320; GATA; 1.
DR PRINTS; PR00619; GATAZNFINGER.
DR SMART; SM00401; ZnF_GATA; 1.
DR PROSITE; PS50114; GATA_ZN_FINGER_2; 1.
PE 2: Evidence at transcript level;
KW Activator; Developmental protein; Differentiation; DNA-binding;
KW Metal-binding; Nucleus; Oogenesis; Reference proteome; Repressor;
KW Spermatogenesis; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..271
FT /note="GATA-type zinc finger protein 1"
FT /id="PRO_0000317557"
FT ZN_FING 206..230
FT /note="GATA-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT REGION 18..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 96..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 170..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 271 AA; 29628 MW; 7F15849AA6E74732 CRC64;
MTEPQVGCVA CPRVHKEPAQ VGTPWPAKPR SHPRKRDPTA LLPRSLWPAC QESVTALCFL
QETVERLGQS PAQDTPVLGP CWDPMALGTQ GRLLLDRDSK DTQTRISQKG RRLQPPGTPS
APPQRRPRKQ LNPCRGTERV DPGFEGVTLK FQIKPDSSLQ IIPTYSLPCS SRSQESPADA
VGGPAAHPGG TEAHSAGSEA LEPRRCASCR TQRTPLWRDA EDGTPLCNAC GIRYKKYGTR
CSSCWLVPRK NVQPKRLCGR CGVSLDPIQE G
