ID   ZGPAT_AEDAE             Reviewed;         512 AA.
AC   Q17CQ8;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Zinc finger CCCH-type with G patch domain-containing protein;
GN   ORFNames=AAEL004458;
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVPib12;
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA   Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA   Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA   Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA   Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA   El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA   Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA   Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA   Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA   Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA   Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA   Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA   Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
CC   -!- FUNCTION: Transcription repressor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; CH477305; EAT44138.1; -; Genomic_DNA.
DR   RefSeq; XP_001649219.1; XM_001649169.1.
DR   AlphaFoldDB; Q17CQ8; -.
DR   SMR; Q17CQ8; -.
DR   STRING; 7159.AAEL004458-PA; -.
DR   GeneID; 5564857; -.
DR   KEGG; aag:5564857; -.
DR   VEuPathDB; VectorBase:AAEL004458; -.
DR   VEuPathDB; VectorBase:AAEL025887; -.
DR   eggNOG; KOG2185; Eukaryota.
DR   HOGENOM; CLU_040504_1_0_1; -.
DR   InParanoid; Q17CQ8; -.
DR   OMA; QYTRGIG; -.
DR   OrthoDB; 1238995at2759; -.
DR   PhylomeDB; Q17CQ8; -.
DR   Proteomes; UP000008820; Chromosome 3.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR000467; G_patch_dom.
DR   InterPro; IPR043560; ZGPAT.
DR   InterPro; IPR000571; Znf_CCCH.
DR   PANTHER; PTHR46297; PTHR46297; 1.
DR   Pfam; PF01585; G-patch; 1.
DR   SMART; SM00443; G_patch; 1.
DR   SMART; SM00356; ZnF_C3H1; 1.
DR   PROSITE; PS50174; G_PATCH; 1.
DR   PROSITE; PS50103; ZF_C3H1; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Repressor;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..512
FT                   /note="Zinc finger CCCH-type with G patch domain-containing
FT                   protein"
FT                   /id="PRO_0000385198"
FT   DOMAIN          308..354
FT                   /note="G-patch"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00092"
FT   ZN_FING         159..186
FT                   /note="C3H1-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT   REGION          255..280
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          407..432
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        263..279
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   512 AA;  57487 MW;  EC4D317BDB56427E CRC64;
     MSGSQDLNDS IRIYNEQLAQ VEQALEGTSS GPERESLINL KSDLEELVKL TLETVQHENG
     DDLNAAASGS NEDDEFALFM REINALDDPG SVDAKPPKPD EVSVDEQEPF KDLVGSKCSA
     PHIHKWGSKS YHNALICSLD ASDLDDVAAK VLFINPTHQE MVPCAYFLEG DCKFNDEMCR
     FSHGELISIN ELKEYREPRF ELLRKKGCKV LAKNRNRIWS KGTIQTADFE TKTCKIQMDE
     GRHEVELQFE NVLPLEGDDV PSSDSESNSD SDEENEDDVV SLQQAQIIER SLLNPAPDQR
     LGDWEKHTKG IGSKIMLKMG YVVGAGLGSK GEGIVVPVSA QVLPQGRSLD YCMQLREQAN
     GDKNLFSVEK KLQREKRIQE KRDAKNYAAN KSKKDVFNFL NSEIFGSSNG SSSSSGSKKP
     AAKDNQMDLP SCSSKNLNIA SLKLSEQMRR LELDIDRLSH SLTRHQPGSK MHSNLQKQIA
     EKRREISEIK KTEYSISREQ QLRNDKRKMT VF