ID   ZGPAT_DANRE             Reviewed;         504 AA.
AC   Q7SXW2;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Zinc finger CCCH-type with G patch domain-containing protein;
GN   Name=zgpat; ORFNames=zgc:63730;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription repressor that specifically binds the 5'-
CC       GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by
CC       recruiting the chromatin multiprotein complex NuRD to target promoters.
CC       Negatively regulates expression of EGFR, a gene involved in cell
CC       proliferation, survival and migration (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; BC055224; AAH55224.1; -; mRNA.
DR   RefSeq; NP_956779.1; NM_200485.1.
DR   AlphaFoldDB; Q7SXW2; -.
DR   SMR; Q7SXW2; -.
DR   STRING; 7955.ENSDARP00000030077; -.
DR   PaxDb; Q7SXW2; -.
DR   Ensembl; ENSDART00000037474; ENSDARP00000030077; ENSDARG00000027403.
DR   Ensembl; ENSDART00000190410; ENSDARP00000153327; ENSDARG00000027403.
DR   GeneID; 393457; -.
DR   KEGG; dre:393457; -.
DR   CTD; 84619; -.
DR   ZFIN; ZDB-GENE-040426-1248; zgpat.
DR   eggNOG; KOG2185; Eukaryota.
DR   GeneTree; ENSGT00390000000732; -.
DR   HOGENOM; CLU_040504_1_0_1; -.
DR   InParanoid; Q7SXW2; -.
DR   OMA; QYTRGIG; -.
DR   OrthoDB; 1238995at2759; -.
DR   PhylomeDB; Q7SXW2; -.
DR   TreeFam; TF105970; -.
DR   PRO; PR:Q7SXW2; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 11.
DR   Bgee; ENSDARG00000027403; Expressed in blastula and 27 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:0007175; P:negative regulation of epidermal growth factor-activated receptor activity; ISS:UniProtKB.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd04508; TUDOR; 1.
DR   InterPro; IPR000467; G_patch_dom.
DR   InterPro; IPR002999; Tudor.
DR   InterPro; IPR043560; ZGPAT.
DR   InterPro; IPR000571; Znf_CCCH.
DR   InterPro; IPR036855; Znf_CCCH_sf.
DR   PANTHER; PTHR46297; PTHR46297; 1.
DR   Pfam; PF01585; G-patch; 1.
DR   SMART; SM00443; G_patch; 1.
DR   SMART; SM00356; ZnF_C3H1; 1.
DR   SUPFAM; SSF90229; SSF90229; 1.
DR   PROSITE; PS50174; G_PATCH; 1.
DR   PROSITE; PS50103; ZF_C3H1; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Repressor;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..504
FT                   /note="Zinc finger CCCH-type with G patch domain-containing
FT                   protein"
FT                   /id="PRO_0000385193"
FT   DOMAIN          308..354
FT                   /note="G-patch"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00092"
FT   ZN_FING         165..191
FT                   /note="C3H1-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT   REGION          95..121
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   504 AA;  55727 MW;  BBD97F858FB2CACD CRC64;
     MDESSLEEAI GTYRAQLQQV ELALSAGLGS AEQDDLLKLK EDLQQLIELT ESSLVSVKKS
     QLLAALEEAS TNQSDTSVPQ ETALDNEFAA FYAELSEDSN EVKPNPDTDE ENEEEEQDIS
     GTKVCAPYRT SWGTLEYHNA MVVCPEEPEG EEARVRVFYI HPTHKSMKPC GFYLEGKCRF
     MDNCRYSHGE VVCVSELRDF LEADISNMES GSACLAKHED GIWYPARISE IEGGFYTVKF
     DSLLLKEAVL EADGIIPPLR QDDVSSSSSS DSEDDAECDG GYAKVFTSRE EDLAQVNTAE
     FCGWEAHTRG IGSKLLMKMG YELGKGLGKT LSGRVEPVQA VVLPKGHSLD ICAELTQRKT
     AAAIAKNNPT SHKRKAKKKK ASTSTRHNVF DFLNSKLGDR AQSASHSSSS LVTGAEAYRG
     GKSTKRSLNV RLFEAAEKVT QVEREIQQLT KSLSKRNGRD AAVVSRLEEK LAASRKLLEQ
     LKAQEQAIQR EQKKADTHKK MTEF