ID   ZGPAT_DROPS             Reviewed;         509 AA.
AC   Q29NF3;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Zinc finger CCCH-type with G patch domain-containing protein;
GN   ORFNames=GA18374;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- FUNCTION: Transcription repressor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; CH379060; EAL33389.1; -; Genomic_DNA.
DR   RefSeq; XP_001356326.1; XM_001356290.2.
DR   AlphaFoldDB; Q29NF3; -.
DR   SMR; Q29NF3; -.
DR   STRING; 7237.FBpp0280274; -.
DR   PRIDE; Q29NF3; -.
DR   EnsemblMetazoa; FBtr0281836; FBpp0280274; FBgn0078377.
DR   GeneID; 4816976; -.
DR   KEGG; dpo:Dpse_GA18374; -.
DR   eggNOG; KOG2185; Eukaryota.
DR   HOGENOM; CLU_040504_1_0_1; -.
DR   InParanoid; Q29NF3; -.
DR   OMA; QYTRGIG; -.
DR   PhylomeDB; Q29NF3; -.
DR   Proteomes; UP000001819; Chromosome 4.
DR   Bgee; FBgn0078377; Expressed in female reproductive system and 3 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR000467; G_patch_dom.
DR   InterPro; IPR043560; ZGPAT.
DR   InterPro; IPR000571; Znf_CCCH.
DR   PANTHER; PTHR46297; PTHR46297; 1.
DR   Pfam; PF01585; G-patch; 1.
DR   SMART; SM00443; G_patch; 1.
DR   PROSITE; PS50174; G_PATCH; 1.
DR   PROSITE; PS50103; ZF_C3H1; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Repressor;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..509
FT                   /note="Zinc finger CCCH-type with G patch domain-containing
FT                   protein"
FT                   /id="PRO_0000385206"
FT   DOMAIN          310..356
FT                   /note="G-patch"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00092"
FT   ZN_FING         155..178
FT                   /note="C3H1-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT   REGION          254..277
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          407..430
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        254..271
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   509 AA;  58263 MW;  152F07A537E472A3 CRC64;
     MDEYEAQLVA VEQALENTTD EQQREELSTL RTNLQELLAL TRETEADQTA QQGDILDDEL
     LRLKSELNEL EEAAANVGAT KNKDEEQQLK DLRAKYNALV GEKCSAPHEH SWGASSYHNA
     LICGVDDEVI INRNSELDVR LRVLYINPTH CEMLPCNYYL EGECRFDEIR CRYSHGALVP
     GASIKSYIPP DFPRLARNCP VLAKMPDRLW HRGRVLCANF VEQTCRVRLD GQDHKERERD
     FQFEELFPLI TEKEDELTSE DSSSSPHDES SDEIDSDMDD LEAAHRSRMV ELSLFTFKPT
     EKLGAWEQYT RGIGSKLMEK MGYIHGTGLG SEGRGIVTPV SAQILPQGRS LDACMELREA
     ANGDQDYFSV ERKLKREQRR QNKANEKAYA RETQRTDVFS FLNGSVLGGG ESRHQGDQAA
     KKAKTNDLQQ HSTKTLNVET VRVADDIRRK QRDIAKVKQS LDRNATDIQL QKRLHMQLQS
     QKQELATLQA HEHRLSKEQH TRKNKMFEF