位置:首页 > 蛋白库 > ZGPAT_MOUSE
ZGPAT_MOUSE
ID   ZGPAT_MOUSE             Reviewed;         511 AA.
AC   Q8VDM1; A2AU20; A2AU21; Q3TW85; Q69Z90; Q8BWW2;
DT   11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 130.
DE   RecName: Full=Zinc finger CCCH-type with G patch domain-containing protein;
GN   Name=Zgpat; Synonyms=Kiaa1847;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Fetal brain;
RX   PubMed=15368895; DOI=10.1093/dnares/11.3.205;
RA   Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA   Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H.,
RA   Nagase T., Ohara O., Koga H.;
RT   "Prediction of the coding sequences of mouse homologues of KIAA gene: IV.
RT   The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT   identified by screening of terminal sequences of cDNA clones randomly
RT   sampled from size-fractionated libraries.";
RL   DNA Res. 11:205-218(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Heart, Spinal cord, and Thymus;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-70; SER-276; THR-280 AND
RP   SER-353, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Heart, Pancreas, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Transcription repressor that specifically binds the 5'-
CC       GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by
CC       recruiting the chromatin multiprotein complex NuRD to target promoters.
CC       Negatively regulates expression of EGFR, a gene involved in cell
CC       proliferation, survival and migration. Its ability to repress genes of
CC       the EGFR pathway suggest it may act as a tumor suppressor (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CHD4/Mi-2; the interaction is direct.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAD32554.1; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown because it seems to be derived from a pre-mRNA.; Evidence={ECO:0000305};
CC       Sequence=CAM26425.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AK173276; BAD32554.1; ALT_SEQ; Transcribed_RNA.
DR   EMBL; AK041491; BAC30962.1; -; mRNA.
DR   EMBL; AK049764; BAC33909.1; -; mRNA.
DR   EMBL; AK052236; BAC34894.1; -; mRNA.
DR   EMBL; AK159801; BAE35381.1; -; mRNA.
DR   EMBL; AL928965; CAM26424.1; -; Genomic_DNA.
DR   EMBL; AL928965; CAM26425.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CH466626; EDL07412.1; -; Genomic_DNA.
DR   EMBL; BC021513; AAH21513.1; -; mRNA.
DR   EMBL; BC027218; AAH27218.1; -; mRNA.
DR   CCDS; CCDS17210.1; -.
DR   RefSeq; NP_001041613.1; NM_001048148.1.
DR   RefSeq; NP_659143.1; NM_144894.3.
DR   AlphaFoldDB; Q8VDM1; -.
DR   SMR; Q8VDM1; -.
DR   BioGRID; 230809; 1.
DR   STRING; 10090.ENSMUSP00000029105; -.
DR   iPTMnet; Q8VDM1; -.
DR   PhosphoSitePlus; Q8VDM1; -.
DR   SwissPalm; Q8VDM1; -.
DR   EPD; Q8VDM1; -.
DR   MaxQB; Q8VDM1; -.
DR   PaxDb; Q8VDM1; -.
DR   PeptideAtlas; Q8VDM1; -.
DR   PRIDE; Q8VDM1; -.
DR   ProteomicsDB; 275367; -.
DR   Antibodypedia; 29857; 120 antibodies from 25 providers.
DR   DNASU; 229007; -.
DR   Ensembl; ENSMUST00000029105; ENSMUSP00000029105; ENSMUSG00000027582.
DR   Ensembl; ENSMUST00000108807; ENSMUSP00000104435; ENSMUSG00000027582.
DR   Ensembl; ENSMUST00000116366; ENSMUSP00000112067; ENSMUSG00000027582.
DR   GeneID; 229007; -.
DR   KEGG; mmu:229007; -.
DR   UCSC; uc008omb.1; mouse.
DR   CTD; 84619; -.
DR   MGI; MGI:2449939; Zgpat.
DR   VEuPathDB; HostDB:ENSMUSG00000027582; -.
DR   eggNOG; KOG2185; Eukaryota.
DR   GeneTree; ENSGT00390000000732; -.
DR   HOGENOM; CLU_040504_1_0_1; -.
DR   InParanoid; Q8VDM1; -.
DR   OMA; QYTRGIG; -.
DR   OrthoDB; 1238995at2759; -.
DR   PhylomeDB; Q8VDM1; -.
DR   TreeFam; TF105970; -.
DR   BioGRID-ORCS; 229007; 2 hits in 74 CRISPR screens.
DR   ChiTaRS; Zgpat; mouse.
DR   PRO; PR:Q8VDM1; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   RNAct; Q8VDM1; protein.
DR   Bgee; ENSMUSG00000027582; Expressed in bronchus and 80 other tissues.
DR   ExpressionAtlas; Q8VDM1; baseline and differential.
DR   Genevisible; Q8VDM1; MM.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; ISO:MGI.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:MGI.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:0007175; P:negative regulation of epidermal growth factor-activated receptor activity; ISS:UniProtKB.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:MGI.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd04508; TUDOR; 1.
DR   InterPro; IPR000467; G_patch_dom.
DR   InterPro; IPR002999; Tudor.
DR   InterPro; IPR043560; ZGPAT.
DR   InterPro; IPR041367; Znf-CCCH_4.
DR   InterPro; IPR000571; Znf_CCCH.
DR   InterPro; IPR036855; Znf_CCCH_sf.
DR   PANTHER; PTHR46297; PTHR46297; 1.
DR   Pfam; PF01585; G-patch; 1.
DR   Pfam; PF18044; zf-CCCH_4; 1.
DR   SMART; SM00443; G_patch; 1.
DR   SMART; SM00356; ZnF_C3H1; 1.
DR   SUPFAM; SSF90229; SSF90229; 1.
DR   PROSITE; PS50174; G_PATCH; 1.
DR   PROSITE; PS50103; ZF_C3H1; 1.
PE   1: Evidence at protein level;
KW   Acetylation; DNA-binding; Metal-binding; Nucleus; Phosphoprotein;
KW   Reference proteome; Repressor; Transcription; Transcription regulation;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..511
FT                   /note="Zinc finger CCCH-type with G patch domain-containing
FT                   protein"
FT                   /id="PRO_0000213895"
FT   DOMAIN          313..359
FT                   /note="G-patch"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00092"
FT   ZN_FING         174..200
FT                   /note="C3H1-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT   REGION          92..129
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          266..291
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          363..393
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          490..511
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        269..291
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        493..511
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8N5A5"
FT   MOD_RES         70
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
FT   MOD_RES         276
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
FT   MOD_RES         280
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
FT   MOD_RES         353
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
FT   CONFLICT        236
FT                   /note="R -> Q (in Ref. 2; BAC33909)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        264
FT                   /note="I -> T (in Ref. 2; BAE35381)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   511 AA;  56411 MW;  13B7C46AB107F918 CRC64;
     MDEDNLETAL QTYRAQLQQV ELALGAGLDA SEQADLRQLQ GDLKELIELT EASLLSVRKS
     KLLSTVDQES PAQEDAEYLA FQKAIAEEVE APGAPCNDSE TAPGSEVQPG STSSALEEEE
     EDPDLEELSG AKVNAPYYSA WGTLEYHNAM VVGAEEAEDG SACVRVLYLY PTHKSLKPCP
     FFLEGKCRFK ENCRFSHGQV VSVDELRPFQ DPDLSLLQTG SACLAKHQDG LWHPARITDV
     DNGYYTVKFD SLLLKEAVVE GDSILPPLRT EATESSDSDT GDASDSSYAR VVEPSTVDTG
     TCSSAFAGWE VHTRGIGSKL LVKMGYEFGK GLGRHAEGRV EPIHAVVLPR GKSLDQCAEI
     LQKKTKRGQA GSNRPPKCRR SGSRPEGRPP PRNVFDFLNE KLQSQVPGTP DAGVDTPERR
     NKDMYHASKS AKQALSLQLF QTEEKIERTQ RDIRGIQEAL TRNTGRHNMT TAHLQEKLEG
     AQRQLGQLRA QEADLQRKQR KADTHRKMTE F
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024