ID   ZGPAT_NEMVE             Reviewed;         508 AA.
AC   A7SBN6;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Zinc finger CCCH-type with G patch domain-containing protein;
GN   ORFNames=v1g244155;
OS   Nematostella vectensis (Starlet sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Edwardsiidae; Nematostella.
OX   NCBI_TaxID=45351;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CH2 X CH6;
RX   PubMed=17615350; DOI=10.1126/science.1139158;
RA   Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA   Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA   Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA   Technau U., Martindale M.Q., Rokhsar D.S.;
RT   "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT   genomic organization.";
RL   Science 317:86-94(2007).
CC   -!- FUNCTION: Transcription repressor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; DS469617; EDO38903.1; -; Genomic_DNA.
DR   RefSeq; XP_001630966.1; XM_001630916.1.
DR   AlphaFoldDB; A7SBN6; -.
DR   SMR; A7SBN6; -.
DR   STRING; 45351.EDO38903; -.
DR   PRIDE; A7SBN6; -.
DR   EnsemblMetazoa; EDO38903; EDO38903; NEMVEDRAFT_v1g244155.
DR   GeneID; 5510508; -.
DR   KEGG; nve:5510508; -.
DR   eggNOG; KOG2185; Eukaryota.
DR   HOGENOM; CLU_040504_1_0_1; -.
DR   InParanoid; A7SBN6; -.
DR   OMA; QYTRGIG; -.
DR   OrthoDB; 1238995at2759; -.
DR   PhylomeDB; A7SBN6; -.
DR   Proteomes; UP000001593; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd04508; TUDOR; 1.
DR   InterPro; IPR000467; G_patch_dom.
DR   InterPro; IPR002999; Tudor.
DR   InterPro; IPR043560; ZGPAT.
DR   InterPro; IPR000571; Znf_CCCH.
DR   PANTHER; PTHR46297; PTHR46297; 1.
DR   Pfam; PF01585; G-patch; 1.
DR   SMART; SM00443; G_patch; 1.
DR   SMART; SM00333; TUDOR; 1.
DR   SMART; SM00356; ZnF_C3H1; 1.
DR   PROSITE; PS50174; G_PATCH; 1.
DR   PROSITE; PS50103; ZF_C3H1; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Repressor;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..508
FT                   /note="Zinc finger CCCH-type with G patch domain-containing
FT                   protein"
FT                   /id="PRO_0000385197"
FT   DOMAIN          310..356
FT                   /note="G-patch"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00092"
FT   ZN_FING         161..188
FT                   /note="C3H1-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT   REGION          67..86
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          253..282
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          404..426
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   508 AA;  57903 MW;  56EAD297AD496184 CRC64;
     MDEDVLKEAI EQYKQQIIQI QTVLESGQIE GRAELAKLKD DLTELIQVTE ESLLSLKKSQ
     LLQLLEQQES SHHDSGTPET DTKTSVDYRN SYVNDHTIDD NDDEDNDENI IGTKCRVAFT
     QEWGVKEHHN AMVFKLESIP LDEETVDQAK VRVLFLNPTH RSMVPCPYFL EGKCKFAGAE
     CRFSHGYLVD VEHLKPFKEP DFSSVKAGQR CLARYSDGVW YNSTIKSIKH ESHEFLIHYE
     TYNTDATLPL DDIYPLGPEE VESDSESDSQ SDTGDSSSSK AAIEQDDDVI RYAWKPTGAL
     SSLGDWEQHT KGIGSKLMAK MGYIFGKGLG KDGEGRVEPI EVVVLPQGKS LDKCAELREK
     NKLKEPFKRK KKKLVVASTT SASQGKASDV FDFINHKLGH SKGSLHDLRV SHPGAKPDIR
     KTRKSADENT NWNIQLFKIH EEISSVKKQL NKQEEALQRH TTRDSRNKTI FTEKRDSVHN
     RLQELLKKEK KIQEKIHQKD QHRKLTVF