CC183_MOUSE
ID CC183_MOUSE Reviewed; 534 AA.
AC A2AJB1; Q9D5S3;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=Coiled-coil domain-containing protein 183;
GN Name=Ccdc183; Synonyms=Kiaa1984;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A2AJB1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A2AJB1-2; Sequence=VSP_026485, VSP_026486;
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DR EMBL; AK014983; BAB29653.1; -; mRNA.
DR EMBL; AL732590; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS50533.1; -. [A2AJB1-1]
DR RefSeq; NP_084135.1; NM_029859.1. [A2AJB1-1]
DR AlphaFoldDB; A2AJB1; -.
DR SMR; A2AJB1; -.
DR STRING; 10090.ENSMUSP00000028309; -.
DR iPTMnet; A2AJB1; -.
DR PhosphoSitePlus; A2AJB1; -.
DR PaxDb; A2AJB1; -.
DR PRIDE; A2AJB1; -.
DR ProteomicsDB; 283718; -. [A2AJB1-1]
DR ProteomicsDB; 283719; -. [A2AJB1-2]
DR Ensembl; ENSMUST00000028309; ENSMUSP00000028309; ENSMUSG00000026940. [A2AJB1-1]
DR GeneID; 77058; -.
DR KEGG; mmu:77058; -.
DR UCSC; uc008isv.2; mouse. [A2AJB1-2]
DR UCSC; uc012bsc.1; mouse. [A2AJB1-1]
DR CTD; 84960; -.
DR MGI; MGI:1924308; Ccdc183.
DR VEuPathDB; HostDB:ENSMUSG00000026940; -.
DR eggNOG; ENOG502QTFP; Eukaryota.
DR GeneTree; ENSGT00940000153116; -.
DR HOGENOM; CLU_575639_0_0_1; -.
DR InParanoid; A2AJB1; -.
DR OMA; LLTIQMG; -.
DR OrthoDB; 622819at2759; -.
DR PhylomeDB; A2AJB1; -.
DR TreeFam; TF324955; -.
DR BioGRID-ORCS; 77058; 0 hits in 73 CRISPR screens.
DR PRO; PR:A2AJB1; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; A2AJB1; protein.
DR Bgee; ENSMUSG00000026940; Expressed in spermatid and 50 other tissues.
DR InterPro; IPR043247; CCDC183.
DR PANTHER; PTHR47115; PTHR47115; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..534
FT /note="Coiled-coil domain-containing protein 183"
FT /id="PRO_0000293466"
FT COILED 10..54
FT /evidence="ECO:0000255"
FT COILED 136..209
FT /evidence="ECO:0000255"
FT COILED 321..406
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..206
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_026485"
FT VAR_SEQ 496..534
FT /note="ETFQFADVDHSYVPSRAEIKKQAQQLIEAKLKGAKKKKK -> GEALHAGHR
FT KMEKDDKNNSCN (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_026486"
SQ SEQUENCE 534 AA; 62117 MW; 515198BAE8E833CD CRC64;
MKVHNEAAVE AQITELRTIT RLQEQCRALQ IQGVKEKTAQ NKATMGILRS NLRRGAQDWA
LAKKHDQWTI SKACGKDTSM RLAHGRSTLE VAREKLRKYV FDRVNTHNIL IHLVRRRGQK
LESLQLELAS LRNQPDATKD ELRQLQIIRQ LENNIEKTVI KITTSQNIHT LYKVLLDYLK
KVLAEYPTEL DKLQNLVANY CSELSDMTVM SQDAMMITDE VKRNMRQGEA TFIEERRARE
NRLNQQKKLI DKIHTKETSE KYRRGRRDLD FPSNLMTMEN VKVKKRKTSV ADIQYQTKVT
TLVERVKSAV QCSHLWDIAG RFLAQKNTEE NLELQMEDCE ERRTQLEALM KKLELEEAVL
KFHQTPSAVG FNSIQKKMKN MLEEEEARLK QAQNNMNKGQ QLLLVIQTGI DNLYIRLIGI
TLPTFQKEIA VSNTLDVYGK LDYCEGKLIY LAERMQTLSR NEEVDTKVRD TLESSTLKEK
HNTRITFEDP EEDMIETFQF ADVDHSYVPS RAEIKKQAQQ LIEAKLKGAK KKKK
