ID   ZGPAT_XENLA             Reviewed;         524 AA.
AC   Q5U4Z3;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Zinc finger CCCH-type with G patch domain-containing protein;
GN   Name=zgpat;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription repressor that specifically binds the 5'-
CC       GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by
CC       recruiting the chromatin multiprotein complex NuRD to target promoters.
CC       Negatively regulates expression of EGFR, a gene involved in cell
CC       proliferation, survival and migration (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; BC084897; AAH84897.1; -; mRNA.
DR   RefSeq; NP_001088537.1; NM_001095068.1.
DR   AlphaFoldDB; Q5U4Z3; -.
DR   SMR; Q5U4Z3; -.
DR   DNASU; 495411; -.
DR   GeneID; 495411; -.
DR   KEGG; xla:495411; -.
DR   CTD; 495411; -.
DR   Xenbase; XB-GENE-6253853; zgpat.L.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:0007175; P:negative regulation of epidermal growth factor-activated receptor activity; ISS:UniProtKB.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   CDD; cd04508; TUDOR; 1.
DR   InterPro; IPR000467; G_patch_dom.
DR   InterPro; IPR002999; Tudor.
DR   InterPro; IPR043560; ZGPAT.
DR   InterPro; IPR000571; Znf_CCCH.
DR   InterPro; IPR036855; Znf_CCCH_sf.
DR   PANTHER; PTHR46297; PTHR46297; 1.
DR   Pfam; PF01585; G-patch; 1.
DR   SMART; SM00443; G_patch; 1.
DR   SMART; SM00356; ZnF_C3H1; 1.
DR   SUPFAM; SSF90229; SSF90229; 1.
DR   PROSITE; PS50174; G_PATCH; 1.
DR   PROSITE; PS50103; ZF_C3H1; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Repressor;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..524
FT                   /note="Zinc finger CCCH-type with G patch domain-containing
FT                   protein"
FT                   /id="PRO_0000385195"
FT   DOMAIN          326..372
FT                   /note="G-patch"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00092"
FT   ZN_FING         184..210
FT                   /note="C3H1-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT   REGION          105..142
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          278..298
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          375..402
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          500..524
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        122..136
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        378..392
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   524 AA;  57880 MW;  C750372DF9916F46 CRC64;
     MDEESLAAAL QTYRAQLEQV DLTLRAVTDP TQLEDLTQLH TDLQQLIELT ESSLLSIQKC
     NLLTSLEGNP SLPFHEDPIS LPALEVPTSL SSQDKEYEAF RMAISEESQP LGSNDETSTC
     SKGSEEEEEE EEEEEDNTSG MKVKAPYYST WGTLEYHNAM VVGSEQMEDG EAGVRVLYLY
     PTHKAMKPCP FFLDGKCLFN DNCRFSHGQV VSVTELQPFK EADLGSLAVD SPCLAQHNDG
     IWYPARITDI ESGFYTVKFD SLLLKESVLE ADSIIPPLRG SDSSSSSSSD EEEDGAAEDS
     VYAKVLGQEI AGTTCSSEFG GWEAHTRGIG SKLLVRMGYE FGKGLGRNAE GRVEPIQAVV
     LPKGKSLDQC MEIQQRKKAG GKHKHKTSKR RPKASGQGGG AKARDIFDFL NEKLEGKFTS
     ACTAETQKTG EKKGKELYNA SKDSKRALSV QVAITAEKIK QKQREICHLK ESLARNAGRE
     SVISNQLEVR LSGARKELAG LQQEERSLQR EQKKADTHKK MTEF