ZGPAT_XENTR
ID ZGPAT_XENTR Reviewed; 514 AA.
AC Q28H71; B3DL93;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 1.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=Zinc finger CCCH-type with G patch domain-containing protein;
GN Name=zgpat; ORFNames=TEgg043k09.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Egg;
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo, and Gastrula;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcription repressor that specifically binds the 5'-
CC GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by
CC recruiting the chromatin multiprotein complex NuRD to target promoters.
CC Negatively regulates expression of EGFR, a gene involved in cell
CC proliferation, survival and migration (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR EMBL; CR761014; CAJ82152.1; -; mRNA.
DR EMBL; BC167358; AAI67358.1; -; mRNA.
DR EMBL; BC171133; AAI71133.1; -; mRNA.
DR EMBL; BC171135; AAI71135.1; -; mRNA.
DR RefSeq; NP_001016444.1; NM_001016444.2.
DR AlphaFoldDB; Q28H71; -.
DR SMR; Q28H71; -.
DR STRING; 8364.ENSXETP00000055302; -.
DR PaxDb; Q28H71; -.
DR GeneID; 549198; -.
DR KEGG; xtr:549198; -.
DR CTD; 84619; -.
DR Xenbase; XB-GENE-6257472; zgpat.
DR eggNOG; KOG2185; Eukaryota.
DR HOGENOM; CLU_117468_0_0_1; -.
DR InParanoid; Q28H71; -.
DR Proteomes; UP000008143; Chromosome 10.
DR Proteomes; UP000790000; Unplaced.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR GO; GO:0007175; P:negative regulation of epidermal growth factor-activated receptor activity; ISS:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd04508; TUDOR; 1.
DR InterPro; IPR000467; G_patch_dom.
DR InterPro; IPR002999; Tudor.
DR InterPro; IPR043560; ZGPAT.
DR InterPro; IPR041367; Znf-CCCH_4.
DR InterPro; IPR000571; Znf_CCCH.
DR PANTHER; PTHR46297; PTHR46297; 1.
DR Pfam; PF01585; G-patch; 1.
DR Pfam; PF18044; zf-CCCH_4; 1.
DR SMART; SM00443; G_patch; 1.
DR SMART; SM00356; ZnF_C3H1; 1.
DR PROSITE; PS50174; G_PATCH; 1.
DR PROSITE; PS50103; ZF_C3H1; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repressor;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..514
FT /note="Zinc finger CCCH-type with G patch domain-containing
FT protein"
FT /id="PRO_0000385196"
FT DOMAIN 315..373
FT /note="G-patch"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00092"
FT ZN_FING 171..197
FT /note="C3H1-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT REGION 96..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 262..288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 363..422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 494..514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 272..287
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 369..385
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 238
FT /note="K -> E (in Ref. 2; AAI67358)"
FT /evidence="ECO:0000305"
FT CONFLICT 274
FT /note="Missing (in Ref. 2; AAI67358)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 514 AA; 56223 MW; 05B5BCB84D97CD04 CRC64;
MEEESLAAAL HTYRAQLEQV ELSLRAGTDP TQLEDLTQLR NDLQQLIELT ESSLLSVRKC
KLLSSLEGSA SLPAPEEPAA ISSQDEEYEA FRRAIGEEPQ PPGAGDGAST GSKDSEEEEE
EEDGSSGMKV KAPYYSTWGT LEYHNAMVVG SEQLEDGEAG VRVLYLYPTH KAMKPCPFFL
DGKCRFDDSC RFSHGQVVAL AELQPFAEAD VASLAVGSPC LAQHSDGIWY PARITDIKSG
FYTVKFDSLL LKESVLEADS IIPPLRGSDS SSSDDDDDDE EEDDAAEDSG YARVLGAGSA
GSAHSSQFGG WEAHTRGIGS KLLARMGYEI GKGLGRNAEG RVEPIQAVLL PKGKSLDQCI
EMQQRKKAGG KREHKAGKRR PRATGRGGGT KSARNVFDFL NEKLEGRPSG AQPGESRRAA
ERKGKELYNA SKDSKRALSV QVAVTAQRIQ QKQREIGHLQ EALARNVGRD SVVSNQLELR
LSGARRELVM LQQEEHSLQR EQRKADTHKK MTEF