ZGRF1_HUMAN
ID ZGRF1_HUMAN Reviewed; 2104 AA.
AC Q86YA3; B3KQX2; B4DSN6; B4DYU8; E9PDE1; G5EA02; Q6ZU11; Q9NSW3; Q9NUJ4;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 16-OCT-2013, sequence version 3.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Protein ZGRF1;
DE AltName: Full=GRF-type zinc finger domain-containing protein 1;
GN Name=ZGRF1; Synonyms=C4orf21;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 5; 6 AND 7), AND
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1136-1204 (ISOFORM 1).
RC TISSUE=Astrocyte, Brain, Placenta, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), AND VARIANT GLU-451.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-793 AND SER-864, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=7;
CC Name=1;
CC IsoId=Q86YA3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q86YA3-2; Sequence=VSP_053232;
CC Name=3;
CC IsoId=Q86YA3-3; Sequence=VSP_053235, VSP_053239, VSP_053241;
CC Name=4;
CC IsoId=Q86YA3-4; Sequence=VSP_053242, VSP_053243;
CC Name=5;
CC IsoId=Q86YA3-5; Sequence=VSP_053237, VSP_053238;
CC Name=6;
CC IsoId=Q86YA3-6; Sequence=VSP_053234, VSP_053236, VSP_053240;
CC Name=7;
CC IsoId=Q86YA3-7; Sequence=VSP_053233, VSP_053244;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC86416.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK002193; BAA92130.1; -; mRNA.
DR EMBL; AK090556; BAG52184.1; -; mRNA.
DR EMBL; AK126054; BAC86416.1; ALT_INIT; mRNA.
DR EMBL; AK299831; BAG61698.1; -; mRNA.
DR EMBL; AK302613; BAG63860.1; -; mRNA.
DR EMBL; AC023886; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471057; EAX06281.1; -; Genomic_DNA.
DR EMBL; AL137700; CAB70881.1; -; mRNA.
DR EMBL; BC044799; AAH44799.1; -; mRNA.
DR CCDS; CCDS3700.2; -. [Q86YA3-1]
DR PIR; T46441; T46441.
DR RefSeq; NP_060862.3; NM_018392.4. [Q86YA3-1]
DR RefSeq; XP_005263172.1; XM_005263115.3. [Q86YA3-1]
DR AlphaFoldDB; Q86YA3; -.
DR SMR; Q86YA3; -.
DR BioGRID; 120626; 16.
DR IntAct; Q86YA3; 11.
DR MINT; Q86YA3; -.
DR STRING; 9606.ENSP00000424737; -.
DR iPTMnet; Q86YA3; -.
DR PhosphoSitePlus; Q86YA3; -.
DR BioMuta; ZGRF1; -.
DR DMDM; 550544257; -.
DR EPD; Q86YA3; -.
DR jPOST; Q86YA3; -.
DR MassIVE; Q86YA3; -.
DR MaxQB; Q86YA3; -.
DR PaxDb; Q86YA3; -.
DR PeptideAtlas; Q86YA3; -.
DR PRIDE; Q86YA3; -.
DR ProteomicsDB; 19644; -.
DR ProteomicsDB; 34100; -.
DR ProteomicsDB; 70390; -. [Q86YA3-1]
DR ProteomicsDB; 70391; -. [Q86YA3-2]
DR Antibodypedia; 48768; 123 antibodies from 19 providers.
DR DNASU; 55345; -.
DR Ensembl; ENST00000309071.9; ENSP00000309095.5; ENSG00000138658.16. [Q86YA3-4]
DR Ensembl; ENST00000445203.6; ENSP00000390505.3; ENSG00000138658.16. [Q86YA3-1]
DR Ensembl; ENST00000505019.6; ENSP00000424737.1; ENSG00000138658.16. [Q86YA3-1]
DR Ensembl; ENST00000612287.4; ENSP00000482897.1; ENSG00000138658.16. [Q86YA3-2]
DR GeneID; 55345; -.
DR KEGG; hsa:55345; -.
DR MANE-Select; ENST00000505019.6; ENSP00000424737.1; NM_018392.5; NP_060862.3.
DR UCSC; uc003iau.4; human. [Q86YA3-1]
DR CTD; 55345; -.
DR DisGeNET; 55345; -.
DR GeneCards; ZGRF1; -.
DR HGNC; HGNC:25654; ZGRF1.
DR HPA; ENSG00000138658; Tissue enhanced (bone).
DR neXtProt; NX_Q86YA3; -.
DR OpenTargets; ENSG00000138658; -.
DR PharmGKB; PA144596502; -.
DR VEuPathDB; HostDB:ENSG00000138658; -.
DR eggNOG; KOG1802; Eukaryota.
DR GeneTree; ENSGT00940000162642; -.
DR HOGENOM; CLU_236590_0_0_1; -.
DR InParanoid; Q86YA3; -.
DR OrthoDB; 62494at2759; -.
DR PhylomeDB; Q86YA3; -.
DR TreeFam; TF335661; -.
DR PathwayCommons; Q86YA3; -.
DR SignaLink; Q86YA3; -.
DR BioGRID-ORCS; 55345; 30 hits in 1060 CRISPR screens.
DR ChiTaRS; ZGRF1; human.
DR GenomeRNAi; 55345; -.
DR Pharos; Q86YA3; Tdark.
DR PRO; PR:Q86YA3; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q86YA3; protein.
DR Bgee; ENSG00000138658; Expressed in ventricular zone and 157 other tissues.
DR ExpressionAtlas; Q86YA3; baseline and differential.
DR Genevisible; Q86YA3; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0017108; F:5'-flap endonuclease activity; IBA:GO_Central.
DR GO; GO:0004386; F:helicase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0071932; P:replication fork reversal; IBA:GO_Central.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR018838; DUF2439.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010666; Znf_GRF.
DR PANTHER; PTHR10887; PTHR10887; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF10382; DUF2439; 1.
DR Pfam; PF06839; zf-GRF; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Metal-binding; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix; Zinc; Zinc-finger.
FT CHAIN 1..2104
FT /note="Protein ZGRF1"
FT /id="PRO_0000286626"
FT TRANSMEM 1944..1964
FT /note="Helical"
FT /evidence="ECO:0000255"
FT ZN_FING 1347..1389
FT /note="GRF-type"
FT REGION 335..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2085..2104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 344..359
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 336
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q0VGT4"
FT MOD_RES 793
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 864
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 1..1865
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_053232"
FT VAR_SEQ 1..1542
FT /note="Missing (in isoform 7)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_053233"
FT VAR_SEQ 1..34
FT /note="MESQEFIVLYTHQKMKKSKVWQDGILKITHLGNK -> MFQ (in
FT isoform 6)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_053234"
FT VAR_SEQ 596..717
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_053235"
FT VAR_SEQ 890..947
FT /note="ILKEDEVELSEPLQSVQFSSSGSKEETAFQAVIPKQIERKTCDPKPVEFQGH
FT QVKGSA -> KTVKKKIKPTLPLRIFINVSRFFCVQLKKMVRLMYINSFISFPLNIVVL
FT SYIINNSS (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_053236"
FT VAR_SEQ 907..927
FT /note="FSSSGSKEETAFQAVIPKQIE -> TGSYSVTQTRVQWHSHSSLQP (in
FT isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_053237"
FT VAR_SEQ 928..2104
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_053238"
FT VAR_SEQ 935..954
FT /note="PVEFQGHQVKGSATSGVMVR -> VKFVKNIDLFNQLHFLFCLK (in
FT isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_053239"
FT VAR_SEQ 948..2104
FT /note="Missing (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_053240"
FT VAR_SEQ 955..2104
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_053241"
FT VAR_SEQ 1044..1062
FT /note="MKKSRSLENENLQRLSLLS -> SRYHIALISVYSFKMKFFI (in
FT isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_053242"
FT VAR_SEQ 1063..2104
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_053243"
FT VAR_SEQ 1543..1566
FT /note="TTLKNIQDYFNPATLPLTQYLLTT -> MNYSTHLFQMPLFLKLFICFIFIR
FT (in isoform 7)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_053244"
FT VARIANT 410
FT /note="N -> S (in dbSNP:rs7696816)"
FT /id="VAR_032147"
FT VARIANT 451
FT /note="G -> E (in dbSNP:rs17854334)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_032148"
FT VARIANT 978
FT /note="T -> I (in dbSNP:rs17669218)"
FT /id="VAR_032149"
FT VARIANT 1410
FT /note="I -> T (in dbSNP:rs3828539)"
FT /id="VAR_037862"
FT VARIANT 1568
FT /note="S -> L (in dbSNP:rs17605622)"
FT /id="VAR_037863"
FT VARIANT 1696
FT /note="S -> C (in dbSNP:rs3762891)"
FT /id="VAR_037864"
FT CONFLICT 374
FT /note="F -> L (in Ref. 1; BAG61698)"
FT /evidence="ECO:0000305"
FT CONFLICT 873
FT /note="I -> V (in Ref. 1; BAG63860)"
FT /evidence="ECO:0000305"
FT CONFLICT 963
FT /note="S -> G (in Ref. 4; AAH44799)"
FT /evidence="ECO:0000305"
FT CONFLICT 1251
FT /note="Y -> M (in Ref. 1; BAG52184)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 2104 AA; 236602 MW; F1791F6656D4CB11 CRC64;
MESQEFIVLY THQKMKKSKV WQDGILKITH LGNKAILYDD KGACLESLFL KCLEVKPGDD
LESDRYLITV EEVKVAGAIG IVKQNVNKEA PELNSRTFIS SGRSLGCQPS GLKRKFTGFQ
GPRQVPKKMV IMESGESAAS HEAKKTGPTI FSPFCSMPPL FPTVGKKDVN NILADPENIV
TYKNRERNAM DFSSVFSPSF QINPEVLCEE NYFCSPVNSG NKLSDSLLTN EPVKRDSLAS
HYSGVSQNIR SKAQILALLK SESSSSCEEL NSEMTEHFPQ KQPQGSLKIA TKPKYLIQQE
ECAEMKSTEN LYYQHQSENT MRNKSRWAMY LSSQSSPIHS STVDGNDTER KPKAQEDDVN
SNLKDLSLQK IIQFVETYAE ERKKYNVDQS VGNNDPSWNQ EVKLEIPSFN ESSSLQVTCS
SAENDGILSE SDIQEDNKIP FNQNDKGCIK GSVLIKENAQ EVNTCGTLEK EYEQSESSLP
ELKHLQIESS NNSRISDDIT DMISESKMDN ESLNSIHESL SNVTQPFLEV TFNLNNFETS
DTEEESQESN KISQDSESWV KDILVNDGNS CFQKRSENTN CEEIEGEHLP FLTSVSDKPT
VTFPVKETLP SQFCDKTYVG FDMGICKTEN TGKEIEEYSD TLSNFESFKW TDAVYGDNKE
DANKPIQEVR INYDFALPPN KSKGINMNLH IPHIQNQIAE NSNLFSEDAQ PQPFILGSDL
DKNDEHVLPS TSSSDNSVQL LNTNQNHYEC IALDKSNTHI SNSLFYPLGK KHLISKDTEA
HISEPEDLGK IRSPPPDHVE VETAREGKQY WNPRNSSELS GLVNTISILK SLCEHSTALD
SLEILKKKNT VFQQGTQQTY EPDSPPEVRK PFITVVSPKS PHLHKDSQQI LKEDEVELSE
PLQSVQFSSS GSKEETAFQA VIPKQIERKT CDPKPVEFQG HQVKGSATSG VMVRGHSSQL
GCSQFPDSTE YENFMTETPE LPSTCMQIDF LQVTSPEENI STLSPVSTFS LNSRDEDFMV
EFSETSLKAR TLPDDLHFLN LEGMKKSRSL ENENLQRLSL LSRTQVPLIT LPRTDGPPDL
DSHSYMINSN TYESSGSPML NLCEKSAVLS FSIEPEDQNE TFFSEESREV NPGDVSLNNI
STQSKWLKYQ NTSQCNVATP NRVDKRITDG FFAEAVSGMH FRDTSERQSD AVNESSLDSV
HLQMIKGMLY QQRQDFSSQD SVSRKKVLSL NLKQTSKTEE IKNVLGGSTC YNYSVKDLQE
ISGSELCFPS GQKIKSAYLP QRQIHIPAVF QSPAHYKQTF TSCLIEHLNI LLFGLAQNLQ
KALSKVDISF YTSLKGEKLK NAENNVPSCH HSQPAKLVMV KKEGPNKGRL FYTCDGPKAD
RCKFFKWLED VTPGYSTQEG ARPGMVLSDI KSIGLYLRSQ KIPLYEECQL LVRKGFDFQR
KQYGKLKKFT TVNPEFYNEP KTKLYLKLSR KERSSAYSKN DLWVVSKTLD FELDTFIACS
AFFGPSSINE IEILPLKGYF PSNWPTNMVV HALLVCNAST ELTTLKNIQD YFNPATLPLT
QYLLTTSSPT IVSNKRVSKR KFIPPAFTNV STKFELLSLG ATLKLASELI QVHKLNKDQA
TALIQIAQMM ASHESIEEVK ELQTHTFPIT IIHGVFGAGK SYLLAVVILF FVQLFEKSEA
PTIGNARPWK LLISSSTNVA VDRVLLGLLS LGFENFIRVG SVRKIAKPIL PYSLHAGSEN
ESEQLKELHA LMKEDLTPTE RVYVRKSIEQ HKLGTNRTLL KQVRVVGVTC AACPFPCMND
LKFPVVVLDE CSQITEPASL LPIARFECEK LILVGDPKQL PPTIQGSDAA HENGLEQTLF
DRLCLMGHKP ILLRTQYRCH PAISAIANDL FYKGALMNGV TEIERSPLLE WLPTLCFYNV
KGLEQIERDN SFHNVAEATF TLKLIQSLIA SGIAGSMIGV ITLYKSQMYK LCHLLSAVDF
HHPDIKTVQV STVDAFQGAE KEIIILSCVR TRQVGFIDSE KRMNVALTRG KRHLLIVGNL
ACLRKNQLWG RVIQHCEGRE DGLQHANQYE PQLNHLLKDY FEKQVEEKQK KKSEKEKSKD
KSHS
