ZH11B_HUMAN
ID ZH11B_HUMAN Reviewed; 371 AA.
AC P0C7U3; A6NHR3;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Probable palmitoyltransferase ZDHHC11B {ECO:0000305};
DE EC=2.3.1.225 {ECO:0000250|UniProtKB:Q9H8X9};
DE AltName: Full=Zinc finger DHHC domain-containing protein 11B {ECO:0000312|HGNC:HGNC:32962};
DE Short=DHHC-11B;
GN Name=ZDHHC11B {ECO:0000312|HGNC:HGNC:32962};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [2]
RP FUNCTION.
RX PubMed=28331227; DOI=10.1038/leu.2017.94;
RA Dzikiewicz-Krawczyk A., Kok K., Slezak-Prochazka I., Robertus J.L.,
RA Bruining J., Tayari M.M., Rutgers B., de Jong D., Koerts J., Seitz A.,
RA Li J., Tillema B., Guikema J.E., Nolte I.M., Diepstra A., Visser L.,
RA Kluiver J., van den Berg A.;
RT "ZDHHC11 and ZDHHC11B are critical novel components of the oncogenic MYC-
RT miR-150-MYB network in Burkitt lymphoma.";
RL Leukemia 31:1470-1473(2017).
CC -!- FUNCTION: Probable palmitoyltransferase that could catalyze the
CC addition of palmitate onto various protein substrates and be involved
CC in a variety of cellular processes (By similarity). May play a role in
CC cell proliferation (PubMed:28331227). {ECO:0000250|UniProtKB:Q9H8X9,
CC ECO:0000269|PubMed:28331227}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-
CC hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA-
CC COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151;
CC EC=2.3.1.225; Evidence={ECO:0000250|UniProtKB:Q9H8X9};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36684;
CC Evidence={ECO:0000250|UniProtKB:Q9H8X9};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- DOMAIN: The DHHC domain is required for palmitoyltransferase activity.
CC {ECO:0000250|UniProtKB:Q8IUH5}.
CC -!- SIMILARITY: Belongs to the DHHC palmitoyltransferase family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC026740; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS87287.1; -.
DR AlphaFoldDB; P0C7U3; -.
DR BioGRID; 575511; 1.
DR STRING; 9606.ENSP00000442373; -.
DR iPTMnet; P0C7U3; -.
DR PhosphoSitePlus; P0C7U3; -.
DR BioMuta; ZDHHC11B; -.
DR DMDM; 206557841; -.
DR MassIVE; P0C7U3; -.
DR PaxDb; P0C7U3; -.
DR PeptideAtlas; P0C7U3; -.
DR PRIDE; P0C7U3; -.
DR Antibodypedia; 64923; 15 antibodies from 6 providers.
DR Ensembl; ENST00000508859.8; ENSP00000442373.2; ENSG00000206077.14.
DR MANE-Select; ENST00000508859.8; ENSP00000442373.2; NM_001351303.2; NP_001338232.1.
DR UCSC; uc063bxc.1; human.
DR GeneCards; ZDHHC11B; -.
DR HGNC; HGNC:32962; ZDHHC11B.
DR HPA; ENSG00000206077; Tissue enriched (brain).
DR neXtProt; NX_P0C7U3; -.
DR OpenTargets; ENSG00000206077; -.
DR VEuPathDB; HostDB:ENSG00000206077; -.
DR eggNOG; KOG1311; Eukaryota.
DR GeneTree; ENSGT00940000161608; -.
DR HOGENOM; CLU_020283_1_1_1; -.
DR InParanoid; P0C7U3; -.
DR OMA; NEHHERQ; -.
DR PhylomeDB; P0C7U3; -.
DR Pharos; P0C7U3; Tdark.
DR PRO; PR:P0C7U3; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; P0C7U3; protein.
DR Bgee; ENSG00000206077; Expressed in cerebellar vermis and 93 other tissues.
DR ExpressionAtlas; P0C7U3; baseline and differential.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0019706; F:protein-cysteine S-palmitoyltransferase activity; IBA:GO_Central.
DR GO; GO:0018230; P:peptidyl-L-cysteine S-palmitoylation; IBA:GO_Central.
DR GO; GO:0006612; P:protein targeting to membrane; IBA:GO_Central.
DR InterPro; IPR001594; Palmitoyltrfase_DHHC.
DR Pfam; PF01529; DHHC; 1.
DR PROSITE; PS50216; DHHC; 1.
PE 3: Inferred from homology;
KW Acyltransferase; Lipoprotein; Membrane; Palmitate; Reference proteome;
KW Transferase; Transmembrane; Transmembrane helix.
FT CHAIN 1..371
FT /note="Probable palmitoyltransferase ZDHHC11B"
FT /id="PRO_0000343747"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 216..236
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 125..175
FT /note="DHHC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00067"
FT REGION 335..371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 335..362
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 155
FT /note="S-palmitoyl cysteine intermediate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00067"
FT VARIANT 42
FT /note="R -> Q (in dbSNP:rs1809933)"
FT /id="VAR_052976"
FT VARIANT 200
FT /note="R -> G (in dbSNP:rs634901)"
FT /id="VAR_052977"
FT VARIANT 228
FT /note="V -> L (in dbSNP:rs3817063)"
FT /id="VAR_061990"
SQ SEQUENCE 371 AA; 41895 MW; 8B3222AB3F1717CF CRC64;
MDTRSGSQCS VTPEAIRNNE ELVLPPRISR VNGWSLPLHY FRVVTWAVFV GLSLATFRIF
IPLLPHSWKY IAYVVTGGIF SFHLVVHLIA SCIDPADSNV RLMKNYSQPM PLFDRSKHAH
VIQNQFCHLC KVTVNKKTKH CISCNKCVSG FDHHCKWINN CVGSRNYWFF FSTVASATAG
MLCLIAILLY VLVQYLVNPR VLRTDPRYED VKNMNTWLLF LPLFPVQVQT LIVVIIRMLV
LLLDLLGLVQ LGQLLIFHIY LKAKKMTTFE YLINTRKEES SKHQAVRKDP YVQMDKGFLQ
QGAGALGSSA QGVKAKSSLL IYKCPCHFCT SVNQDGDSKA QEADDAPSTS TLGLQQETTE
PMKTDSAESE D
