ZHANG_MOUSE
ID ZHANG_MOUSE Reviewed; 358 AA.
AC Q91ZR3; Q91Y72;
DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 07-JUL-2009, sequence version 2.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=CREB/ATF bZIP transcription factor;
DE AltName: Full=Host cell factor-binding transcription factor Zhangfei;
DE Short=HCF-binding transcription factor Zhangfei;
DE AltName: Full=Tyrosine kinase-associated leucine zipper protein LAZip;
GN Name=Crebzf; Synonyms=Zf;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAL04512.1}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 33-358.
RC STRAIN=NIH Swiss {ECO:0000312|EMBL:AAL04512.1};
RA Lee O.-H., Yun Y.;
RT "LAZip, a leucine-zipper protein, associates with the SH2 domain of
RT p56lck.";
RL Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000305, ECO:0000312|EMBL:AAL04512.1}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 187-358.
RC STRAIN=C57B/c; TISSUE=Brain;
RA Lee J., Choi Y.B., Yun Y.;
RT "LAZip, a gene containing a leucine zipper domain.";
RL Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Strongly activates transcription when bound to HCFC1.
CC Suppresses the expression of HSV proteins in cells infected with the
CC virus in a HCFC1-dependent manner. Also suppresses the HCFC1-dependent
CC transcriptional activation by CREB3 and reduces the amount of CREB3 in
CC the cell. Able to down-regulate expression of some cellular genes in
CC CREBZF-expressing cells (By similarity).
CC {ECO:0000250|UniProtKB:Q9NS37}.
CC -!- SUBUNIT: Interacts with HCFC1; the interaction inhibits CREB3
CC transcriptional activity. Interacts with CREB3; the interaction occurs
CC only in combination with HCFC1. {ECO:0000250|UniProtKB:Q9NS37}.
CC -!- INTERACTION:
CC Q91ZR3; P62509: Esrrg; NbExp=3; IntAct=EBI-5274001, EBI-5274019;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9NS37}.
CC Note=Colocalizes in promyelocytic leukemia protein nuclear bodies (PML-
CC NB) with CREB3 and HCFC1. {ECO:0000250|UniProtKB:Q9NS37}.
CC -!- SIMILARITY: Belongs to the bZIP family. ATF subfamily. {ECO:0000255}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK51608.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence derived from chromosome 13 in the N-terminal part.; Evidence={ECO:0000305};
CC Sequence=AAL04512.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AC100322; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF408398; AAL04512.1; ALT_INIT; mRNA.
DR EMBL; AF149050; AAK51608.1; ALT_SEQ; mRNA.
DR CCDS; CCDS40020.1; -.
DR RefSeq; NP_660133.2; NM_145151.3.
DR RefSeq; XP_006507669.1; XM_006507606.2.
DR AlphaFoldDB; Q91ZR3; -.
DR SMR; Q91ZR3; -.
DR BioGRID; 231418; 1.
DR IntAct; Q91ZR3; 1.
DR STRING; 10090.ENSMUSP00000102824; -.
DR iPTMnet; Q91ZR3; -.
DR PhosphoSitePlus; Q91ZR3; -.
DR MaxQB; Q91ZR3; -.
DR PaxDb; Q91ZR3; -.
DR PeptideAtlas; Q91ZR3; -.
DR PRIDE; Q91ZR3; -.
DR ProteomicsDB; 274991; -.
DR Antibodypedia; 31388; 203 antibodies from 27 providers.
DR DNASU; 233490; -.
DR Ensembl; ENSMUST00000061767; ENSMUSP00000050972; ENSMUSG00000051451.
DR GeneID; 233490; -.
DR KEGG; mmu:233490; -.
DR UCSC; uc009ihl.2; mouse.
DR CTD; 58487; -.
DR MGI; MGI:2675296; Crebzf.
DR VEuPathDB; HostDB:ENSMUSG00000051451; -.
DR eggNOG; ENOG502S3I0; Eukaryota.
DR GeneTree; ENSGT00390000016589; -.
DR InParanoid; Q91ZR3; -.
DR OMA; PEDMDFL; -.
DR OrthoDB; 1294014at2759; -.
DR PhylomeDB; Q91ZR3; -.
DR TreeFam; TF336153; -.
DR BioGRID-ORCS; 233490; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Crebzf; mouse.
DR PRO; PR:Q91ZR3; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q91ZR3; protein.
DR Bgee; ENSMUSG00000051451; Expressed in retinal neural layer and 264 other tissues.
DR ExpressionAtlas; Q91ZR3; baseline and differential.
DR Genevisible; Q91ZR3; MM.
DR GO; GO:0005739; C:mitochondrion; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0090575; C:RNA polymerase II transcription regulator complex; ISO:MGI.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR GO; GO:0045814; P:negative regulation of gene expression, epigenetic; ISS:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0051090; P:regulation of DNA-binding transcription factor activity; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0009615; P:response to virus; ISO:MGI.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR046347; bZIP_sf.
DR Pfam; PF00170; bZIP_1; 1.
DR SUPFAM; SSF57959; SSF57959; 1.
PE 1: Evidence at protein level;
KW Nucleus; Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..358
FT /note="CREB/ATF bZIP transcription factor"
FT /id="PRO_0000076646"
FT DOMAIN 208..271
FT /note="bZIP"
FT REGION 1..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 119..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 176..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 223..230
FT /note="Basic motif"
FT /evidence="ECO:0000250"
FT REGION 236..271
FT /note="Leucine-zipper"
FT /evidence="ECO:0000250"
FT MOTIF 307..310
FT /note="HCFC1-binding motif (HBM)"
FT /evidence="ECO:0000250|UniProtKB:Q9NS37"
FT COMPBIAS 14..28
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..65
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 49
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NS37"
SQ SEQUENCE 358 AA; 37825 MW; F7CC810EC242C24D CRC64;
MRHSLTKLLA ASGRDFPSRR DSREPPATRA PPREPSGAAA GAETPRPGSP DREQPHGDGD
GGEPEARSGS RGSVAVRAPA PSPLKMEEEE EDAIAMVPKE EPEDMDFLSG LELADLLDPR
QPDWHLEPGL SSPGPLSSSG GGSESGGLLR GDDDDDTAAA EMQRFSDLLQ RLLNGIGGCS
SGGDRGGGEK RRRKSPGAGG GGANDGNQAA TKSPRKAAAA AARLNRLKKK EYVMGLESRV
RGLAAENQEL RAENRELGKR VQALQEESRY LRAVLANETG LARLLSRLSG VGLRLTTSLF
RDSPAGDHDY ALPVGKQPPE PREEDDAAGG VCLHVDKDKV SVEFCSACAR KASSSLKM
