ZHD11_ARATH
ID ZHD11_ARATH Reviewed; 242 AA.
AC Q9SEZ1;
DT 16-MAY-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Zinc-finger homeodomain protein 11;
DE Short=AtZHD11;
DE AltName: Full=Transcription factor HB29;
DE Short=AtHB-29;
DE AltName: Full=Zinc finger homeodomain transcription factor 1;
GN Name=ZHD11; Synonyms=HB29, ZFHD1; OrderedLocusNames=At1g69600;
GN ORFNames=F24J1.29;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP FUNCTION, GENE FAMILY, SUBUNIT, HOMODIMERIZATION, TISSUE SPECIFICITY,
RP DISRUPTION PHENOTYPE, AND INTERACTION WITH ZHD1; ZHD2; ZHD3; ZHD4; ZHD5;
RP ZHD6; ZHD7; ZHD8; ZHD9; ZHD12; ZHD13 AND ZHD14.
RX PubMed=16428600; DOI=10.1104/pp.105.070565;
RA Tan Q.K., Irish V.F.;
RT "The Arabidopsis zinc finger-homeodomain genes encode proteins with unique
RT biochemical properties that are coordinately expressed during floral
RT development.";
RL Plant Physiol. 140:1095-1108(2006).
RN [4]
RP FUNCTION, INDUCTION, AND INTERACTION WITH NAC019; NAC055 AND NAC072.
RX PubMed=17233795; DOI=10.1111/j.1365-313x.2006.02932.x;
RA Tran L.S., Nakashima K., Sakuma Y., Osakabe Y., Qin F., Simpson S.D.,
RA Maruyama K., Fujita Y., Shinozaki K., Yamaguchi-Shinozaki K.;
RT "Co-expression of the stress-inducible zinc finger homeodomain ZFHD1 and
RT NAC transcription factors enhances expression of the ERD1 gene in
RT Arabidopsis.";
RL Plant J. 49:46-63(2007).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18713354; DOI=10.1111/j.1744-7909.2008.00681.x;
RA Hu W., dePamphilis C.W., Ma H.;
RT "Phylogenetic analysis of the plant-specific zinc finger-homeobox and mini
RT zinc finger gene families.";
RL J. Integr. Plant Biol. 50:1031-1045(2008).
RN [6]
RP INTERACTION WITH HIPP20; HIPP21; HIPP22; HIPP23; HIPP24; HIPP26; HIPP27 AND
RP HIPP30.
RX PubMed=18974936; DOI=10.1007/s11103-008-9419-0;
RA Barth O., Vogt S., Uhlemann R., Zschiesche W., Humbeck K.;
RT "Stress induced and nuclear localized HIPP26 from Arabidopsis thaliana
RT interacts via its heavy metal associated domain with the drought stress
RT related zinc finger transcription factor ATHB29.";
RL Plant Mol. Biol. 69:213-226(2009).
RN [7]
RP GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=21059647; DOI=10.1074/jbc.m110.167692;
RA Hong S.-Y., Kim O.-K., Kim S.-G., Yang M.-S., Park C.-M.;
RT "Nuclear import and DNA binding of the ZHD5 transcription factor is
RT modulated by a competitive peptide inhibitor in Arabidopsis.";
RL J. Biol. Chem. 286:1659-1668(2011).
RN [8]
RP INTERACTION WITH MED25, AND DISRUPTION PHENOTYPE.
RX PubMed=21536906; DOI=10.1073/pnas.1002981108;
RA Elfving N., Davoine C., Benlloch R., Blomberg J., Braennstroem K.,
RA Mueller D., Nilsson A., Ulfstedt M., Ronne H., Wingsle G., Nilsson O.,
RA Bjoerklund S.;
RT "The Arabidopsis thaliana Med25 mediator subunit integrates environmental
RT cues to control plant development.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:8245-8250(2011).
CC -!- FUNCTION: Transcription factor involved in the up-regulation of several
CC stress-inducible genes. Acts as a transcriptional activator by
CC interacting with MED25 and NAC proteins. Involved in increased drought
CC tolerance. {ECO:0000269|PubMed:16428600, ECO:0000269|PubMed:17233795}.
CC -!- SUBUNIT: Homo- and heterodimer with other ZFHD proteins. Interacts with
CC HIPP20, HIPP21, HIPP22, HIPP23, HIPP24, HIPP26, HIPP27, HIPP30 and
CC MED25 (via ACID domain). Interacts with NAC019, NAC055 and NAC072 (via
CC NAC binding domain). Binds to ZHD1, ZHD2, ZHD3, ZHD4, ZHD5, ZHD6, ZHD7,
CC ZHD8, ZHD9, ZHD12, ZHD13 and ZHD14. {ECO:0000269|PubMed:16428600,
CC ECO:0000269|PubMed:17233795, ECO:0000269|PubMed:18974936,
CC ECO:0000269|PubMed:21536906}.
CC -!- INTERACTION:
CC Q9SEZ1; Q9SZN7: HIPP26; NbExp=3; IntAct=EBI-1806317, EBI-2008207;
CC Q9SEZ1; Q7XYY2-1: MED25; NbExp=3; IntAct=EBI-1806317, EBI-15924435;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in roots, inflorescences, open flowers
CC and seeds. Detected in stems and seedlings.
CC {ECO:0000269|PubMed:16428600}.
CC -!- INDUCTION: Up-regulated by abscisic acid and by drought and salt
CC stress. Not induced by cold. {ECO:0000269|PubMed:17233795}.
CC -!- DOMAIN: The C-terminus contains the DNA-binding domain (156-218) while
CC the N-terminus contains the transcriptional activation domain (8-82).
CC -!- DOMAIN: The homeodomain differs form the typical one by having namely 4
CC instead of 3 extra amino acids inserted in the loop between helix 1 and
CC helix 2.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype. Increased sensitivity to
CC salt stress. {ECO:0000269|PubMed:16428600,
CC ECO:0000269|PubMed:21536906}.
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DR EMBL; AC021046; AAF24606.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE34954.1; -; Genomic_DNA.
DR PIR; F96717; F96717.
DR RefSeq; NP_177118.1; NM_105628.2.
DR AlphaFoldDB; Q9SEZ1; -.
DR SMR; Q9SEZ1; -.
DR BioGRID; 28517; 24.
DR DIP; DIP-46552N; -.
DR IntAct; Q9SEZ1; 21.
DR STRING; 3702.AT1G69600.1; -.
DR PaxDb; Q9SEZ1; -.
DR PRIDE; Q9SEZ1; -.
DR ProteomicsDB; 232320; -.
DR EnsemblPlants; AT1G69600.1; AT1G69600.1; AT1G69600.
DR GeneID; 843296; -.
DR Gramene; AT1G69600.1; AT1G69600.1; AT1G69600.
DR KEGG; ath:AT1G69600; -.
DR Araport; AT1G69600; -.
DR TAIR; locus:2026734; AT1G69600.
DR eggNOG; ENOG502QWG3; Eukaryota.
DR HOGENOM; CLU_039237_0_0_1; -.
DR InParanoid; Q9SEZ1; -.
DR OMA; NFISFYH; -.
DR OrthoDB; 1442390at2759; -.
DR PhylomeDB; Q9SEZ1; -.
DR PRO; PR:Q9SEZ1; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9SEZ1; baseline and differential.
DR Genevisible; Q9SEZ1; AT.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IDA:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:TAIR.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0009414; P:response to water deprivation; IMP:TAIR.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR006455; Homeodomain_ZF_HD.
DR InterPro; IPR006456; ZF_HD_homeobox_Cys/His_dimer.
DR Pfam; PF04770; ZF-HD_dimer; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR TIGRFAMs; TIGR01565; homeo_ZF_HD; 1.
DR TIGRFAMs; TIGR01566; ZF_HD_prot_N; 1.
DR PROSITE; PS51523; ZF_HD_DIMER; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Homeobox; Metal-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..242
FT /note="Zinc-finger homeodomain protein 11"
FT /id="PRO_0000417499"
FT ZN_FING 31..82
FT /note="ZF-HD dimerization-type; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00856"
FT DNA_BIND 156..213
FT /note="Homeobox; atypical"
FT REGION 83..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 135..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 89..109
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..150
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 208
FT /note="Required for DNA-binding"
FT /evidence="ECO:0000250"
SQ SEQUENCE 242 AA; 26284 MW; 9786B91E121EC5F4 CRC64;
MDLSSKPQQQ LLNSLPIAGE LTVTGEMGVC YKECLKNHAA NLGGHALDGC GEFMPSPTAT
STDPSSLRCA ACGCHRNFHR RDPSENLNFL TAPPISSPSG TESPPSRHVS SPVPCSYYTS
APPHHVILSL SSGFPGPSDQ DPTVVRSENS SRGAMRKRTR TKFTPEQKIK MRAFAEKAGW
KINGCDEKSV REFCNEVGIE RGVLKVWMHN NKYSLLNGKI REIEHGLCLN THSNDGDGSS
SS
