ZHD12_ARATH
ID ZHD12_ARATH Reviewed; 223 AA.
AC Q9FKJ9; F4JYZ9;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Zinc-finger homeodomain protein 12;
DE Short=AtZHD12;
DE AltName: Full=Homeobox protein 26;
DE Short=AtHB-26;
GN Name=ZHD12; Synonyms=HB26; OrderedLocusNames=At5g60480; ORFNames=MUF9.11;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9679202; DOI=10.1093/dnares/5.2.131;
RA Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence
RT features of the regions of 1,381,565 bp covered by twenty one physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:131-145(1998).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP INTERACTION WITH ZHD11, AND GENE FAMILY.
RX PubMed=16428600; DOI=10.1104/pp.105.070565;
RA Tan Q.K., Irish V.F.;
RT "The Arabidopsis zinc finger-homeodomain genes encode proteins with unique
RT biochemical properties that are coordinately expressed during floral
RT development.";
RL Plant Physiol. 140:1095-1108(2006).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18713354; DOI=10.1111/j.1744-7909.2008.00681.x;
RA Hu W., dePamphilis C.W., Ma H.;
RT "Phylogenetic analysis of the plant-specific zinc finger-homeobox and mini
RT zinc finger gene families.";
RL J. Integr. Plant Biol. 50:1031-1045(2008).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=21059647; DOI=10.1074/jbc.m110.167692;
RA Hong S.-Y., Kim O.-K., Kim S.-G., Yang M.-S., Park C.-M.;
RT "Nuclear import and DNA binding of the ZHD5 transcription factor is
RT modulated by a competitive peptide inhibitor in Arabidopsis.";
RL J. Biol. Chem. 286:1659-1668(2011).
CC -!- FUNCTION: Putative transcription factor.
CC -!- SUBUNIT: Homo- and heterodimer with other ZFHD proteins (By
CC similarity). Interacts with ZHD11. {ECO:0000250,
CC ECO:0000269|PubMed:16428600}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- DOMAIN: The homeodomain differs form the typical one by having namely 4
CC instead of 3 extra amino acids inserted in the loop between helix 1 and
CC helix 2.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB011483; BAB08231.1; -; Genomic_DNA.
DR EMBL; CP002688; AED97335.2; -; Genomic_DNA.
DR RefSeq; NP_200856.2; NM_125441.2.
DR AlphaFoldDB; Q9FKJ9; -.
DR SMR; Q9FKJ9; -.
DR BioGRID; 21413; 11.
DR IntAct; Q9FKJ9; 11.
DR STRING; 3702.AT5G60480.1; -.
DR iPTMnet; Q9FKJ9; -.
DR PaxDb; Q9FKJ9; -.
DR PRIDE; Q9FKJ9; -.
DR EnsemblPlants; AT5G60480.1; AT5G60480.1; AT5G60480.
DR GeneID; 836169; -.
DR Gramene; AT5G60480.1; AT5G60480.1; AT5G60480.
DR KEGG; ath:AT5G60480; -.
DR Araport; AT5G60480; -.
DR TAIR; locus:2175138; AT5G60480.
DR eggNOG; ENOG502QWG3; Eukaryota.
DR HOGENOM; CLU_039237_2_2_1; -.
DR OMA; WIHNNKY; -.
DR OrthoDB; 1442390at2759; -.
DR PhylomeDB; Q9FKJ9; -.
DR PRO; PR:Q9FKJ9; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FKJ9; baseline and differential.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; ISS:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR006455; Homeodomain_ZF_HD.
DR InterPro; IPR006456; ZF_HD_homeobox_Cys/His_dimer.
DR Pfam; PF04770; ZF-HD_dimer; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR TIGRFAMs; TIGR01565; homeo_ZF_HD; 1.
DR TIGRFAMs; TIGR01566; ZF_HD_prot_N; 1.
DR PROSITE; PS51523; ZF_HD_DIMER; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Homeobox; Metal-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..223
FT /note="Zinc-finger homeodomain protein 12"
FT /id="PRO_0000426025"
FT ZN_FING 37..88
FT /note="ZF-HD dimerization-type; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00856"
FT DNA_BIND 147..204
FT /note="Homeobox; atypical"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 199
FT /note="Required for DNA-binding"
FT /evidence="ECO:0000250"
SQ SEQUENCE 223 AA; 25237 MW; AF32FC576CE75373 CRC64;
MSSLSKPNRQ FLSPTTNNQD TGREQTIACA RDMVVLYNEC LKNHAVSLGG HALDGCGEFT
PKSTTILTDP PSLRCDACGC HRNFHRRSPS DGFSQHRSPP SPLQLQPLAP VPNLLLSLSS
GFFGPSDQEV KNKFTVERDV RKTAMIKKHK RTKFTAEQKV KMRGFAERAG WKINGWDEKW
VREFCSEVGI ERKVLKVWIH NNKYFNNGRS RDTTSSMSLN LKL
