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ZHD13_ARATH
ID   ZHD13_ARATH             Reviewed;         242 AA.
AC   Q9FMY7; Q8LGB1;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Zinc-finger homeodomain protein 13;
DE            Short=AtZHD13;
DE   AltName: Full=Homeobox protein 27;
DE            Short=AtHB-27;
GN   Name=ZHD13; Synonyms=HB27; OrderedLocusNames=At5g42780; ORFNames=MJB21.16;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=9501997; DOI=10.1093/dnares/4.6.401;
RA   Nakamura Y., Sato S., Kaneko T., Kotani H., Asamizu E., Miyajima N.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. III. Sequence
RT   features of the regions of 1,191,918 bp covered by seventeen physically
RT   assigned P1 clones.";
RL   DNA Res. 4:401-414(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Full-length cDNA from Arabidopsis thaliana.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   INTERACTION WITH ZHD11, TISSUE SPECIFICITY, AND GENE FAMILY.
RX   PubMed=16428600; DOI=10.1104/pp.105.070565;
RA   Tan Q.K., Irish V.F.;
RT   "The Arabidopsis zinc finger-homeodomain genes encode proteins with unique
RT   biochemical properties that are coordinately expressed during floral
RT   development.";
RL   Plant Physiol. 140:1095-1108(2006).
RN   [6]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=18713354; DOI=10.1111/j.1744-7909.2008.00681.x;
RA   Hu W., dePamphilis C.W., Ma H.;
RT   "Phylogenetic analysis of the plant-specific zinc finger-homeobox and mini
RT   zinc finger gene families.";
RL   J. Integr. Plant Biol. 50:1031-1045(2008).
RN   [7]
RP   INTERACTION WITH MIF1; MIF2 AND MIF3, GENE FAMILY, AND NOMENCLATURE.
RC   STRAIN=cv. Columbia;
RX   PubMed=21059647; DOI=10.1074/jbc.m110.167692;
RA   Hong S.-Y., Kim O.-K., Kim S.-G., Yang M.-S., Park C.-M.;
RT   "Nuclear import and DNA binding of the ZHD5 transcription factor is
RT   modulated by a competitive peptide inhibitor in Arabidopsis.";
RL   J. Biol. Chem. 286:1659-1668(2011).
CC   -!- FUNCTION: Putative transcription factor.
CC   -!- SUBUNIT: Homo- and heterodimer with other ZFHD proteins (By
CC       similarity). Interacts with MIF1, MIF2 and MIF3; these interactions
CC       prevent nuclear localization and DNA-binding to inhibit transcription
CC       regulation activity. Binds to ZHD11. {ECO:0000250,
CC       ECO:0000269|PubMed:16428600, ECO:0000269|PubMed:21059647}.
CC   -!- INTERACTION:
CC       Q9FMY7; Q9FIW9: ZHD10; NbExp=4; IntAct=EBI-1806559, EBI-1806298;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Interactions with MIF
CC       proteins prevent nuclear subcellular location and leads to a scattered
CC       repartition throughout the cytoplasm. {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Mostly expressed in flowers.
CC       {ECO:0000269|PubMed:16428600}.
CC   -!- DOMAIN: The homeodomain differs form the typical one by having namely 4
CC       instead of 3 extra amino acids inserted in the loop between helix 1 and
CC       helix 2.
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DR   EMBL; AB007647; BAB10634.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED94862.1; -; Genomic_DNA.
DR   EMBL; BT002832; AAO22651.1; -; mRNA.
DR   EMBL; BT004379; AAO42373.1; -; mRNA.
DR   EMBL; AY084367; AAM60948.1; -; mRNA.
DR   RefSeq; NP_199092.1; NM_123643.3.
DR   AlphaFoldDB; Q9FMY7; -.
DR   SMR; Q9FMY7; -.
DR   BioGRID; 19538; 14.
DR   IntAct; Q9FMY7; 15.
DR   STRING; 3702.AT5G42780.1; -.
DR   PaxDb; Q9FMY7; -.
DR   PRIDE; Q9FMY7; -.
DR   ProteomicsDB; 242348; -.
DR   EnsemblPlants; AT5G42780.1; AT5G42780.1; AT5G42780.
DR   GeneID; 834288; -.
DR   Gramene; AT5G42780.1; AT5G42780.1; AT5G42780.
DR   KEGG; ath:AT5G42780; -.
DR   Araport; AT5G42780; -.
DR   TAIR; locus:2165502; AT5G42780.
DR   eggNOG; ENOG502QZSB; Eukaryota.
DR   HOGENOM; CLU_039237_2_2_1; -.
DR   InParanoid; Q9FMY7; -.
DR   OMA; TTAYDGC; -.
DR   OrthoDB; 1420849at2759; -.
DR   PRO; PR:Q9FMY7; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q9FMY7; baseline and differential.
DR   Genevisible; Q9FMY7; AT.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; ISS:TAIR.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR006455; Homeodomain_ZF_HD.
DR   InterPro; IPR006456; ZF_HD_homeobox_Cys/His_dimer.
DR   Pfam; PF04770; ZF-HD_dimer; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   TIGRFAMs; TIGR01565; homeo_ZF_HD; 1.
DR   TIGRFAMs; TIGR01566; ZF_HD_prot_N; 1.
DR   PROSITE; PS51523; ZF_HD_DIMER; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Homeobox; Metal-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..242
FT                   /note="Zinc-finger homeodomain protein 13"
FT                   /id="PRO_0000426026"
FT   ZN_FING         64..111
FT                   /note="ZF-HD dimerization-type; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00856"
FT   DNA_BIND        179..238
FT                   /note="Homeobox"
FT   REGION          144..166
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        146..166
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            231
FT                   /note="Required for DNA-binding"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        123
FT                   /note="V -> I (in Ref. 4; AAM60948)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   242 AA;  27968 MW;  8BBC8FD44858FA4F CRC64;
     MDEIKPKKEE NSKRRRNVKP ICRETGDHVH YLPTCKTKPK PTRTHHAPPP ILDSIFKVTH
     KPHYYECRKN HAADIGTTAY DGCGEFVSST GEEDSLNCAA CGCHRNFHRE ELIPENGGVT
     ETVLEVLKIS SCQFRRIFCS PYGGGKSEGK KKKKEKESYG GDPIIKDRFG GAEEEEGIVK
     RLKTKFTAEQ TEKMRDYAEK LRWKVRPERQ EEVEEFCVEI GVNRKNFRIW MNNHKDKIII
     DE
 
 
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