ZHD14_ARATH
ID ZHD14_ARATH Reviewed; 168 AA.
AC Q9LQW3;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Zinc-finger homeodomain protein 14;
DE Short=AtZHD14;
DE AltName: Full=Homeobox protein 32;
DE Short=AtHB-32;
GN Name=ZHD14; Synonyms=HB32; OrderedLocusNames=At1g14687; ORFNames=F10B6.7;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP INTERACTION WITH ZHD11, TISSUE SPECIFICITY, AND GENE FAMILY.
RX PubMed=16428600; DOI=10.1104/pp.105.070565;
RA Tan Q.K., Irish V.F.;
RT "The Arabidopsis zinc finger-homeodomain genes encode proteins with unique
RT biochemical properties that are coordinately expressed during floral
RT development.";
RL Plant Physiol. 140:1095-1108(2006).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18713354; DOI=10.1111/j.1744-7909.2008.00681.x;
RA Hu W., dePamphilis C.W., Ma H.;
RT "Phylogenetic analysis of the plant-specific zinc finger-homeobox and mini
RT zinc finger gene families.";
RL J. Integr. Plant Biol. 50:1031-1045(2008).
RN [7]
RP GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=21059647; DOI=10.1074/jbc.m110.167692;
RA Hong S.-Y., Kim O.-K., Kim S.-G., Yang M.-S., Park C.-M.;
RT "Nuclear import and DNA binding of the ZHD5 transcription factor is
RT modulated by a competitive peptide inhibitor in Arabidopsis.";
RL J. Biol. Chem. 286:1659-1668(2011).
CC -!- FUNCTION: Putative transcription factor.
CC -!- SUBUNIT: Homo- and heterodimer with other ZFHD proteins (By
CC similarity). Interacts with ZHD11. {ECO:0000250,
CC ECO:0000269|PubMed:16428600}.
CC -!- INTERACTION:
CC Q9LQW3; Q9LUJ5: EBP2; NbExp=3; IntAct=EBI-1806701, EBI-25515709;
CC Q9LQW3; A0A2H1ZEF6: IAA15; NbExp=3; IntAct=EBI-1806701, EBI-25524519;
CC Q9LQW3; P93830: IAA17; NbExp=3; IntAct=EBI-1806701, EBI-632243;
CC Q9LQW3; O24410: IAA20; NbExp=3; IntAct=EBI-1806701, EBI-632272;
CC Q9LQW3; Q93WC4: IAA29; NbExp=3; IntAct=EBI-1806701, EBI-3946697;
CC Q9LQW3; Q38827: IAA9; NbExp=4; IntAct=EBI-1806701, EBI-632216;
CC Q9LQW3; Q9FNZ4: NIMIN-3; NbExp=3; IntAct=EBI-1806701, EBI-541115;
CC Q9LQW3; Q9FIW9: ZHD10; NbExp=3; IntAct=EBI-1806701, EBI-1806298;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Mostly expressed in flowers and stems.
CC {ECO:0000269|PubMed:16428600}.
CC -!- DOMAIN: The homeodomain differs form the typical one by having namely 4
CC instead of 3 extra amino acids inserted in the loop between helix 1 and
CC helix 2.
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DR EMBL; AC006917; AAF79220.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE29206.1; -; Genomic_DNA.
DR EMBL; BT003942; AAO41987.1; -; mRNA.
DR EMBL; BT005027; AAO50560.1; -; mRNA.
DR EMBL; AY086523; AAM63522.1; -; mRNA.
DR RefSeq; NP_563956.1; NM_101337.4.
DR AlphaFoldDB; Q9LQW3; -.
DR SMR; Q9LQW3; -.
DR BioGRID; 23273; 24.
DR IntAct; Q9LQW3; 26.
DR STRING; 3702.AT1G14687.1; -.
DR iPTMnet; Q9LQW3; -.
DR PaxDb; Q9LQW3; -.
DR PRIDE; Q9LQW3; -.
DR ProteomicsDB; 242965; -.
DR EnsemblPlants; AT1G14687.1; AT1G14687.1; AT1G14687.
DR GeneID; 838033; -.
DR Gramene; AT1G14687.1; AT1G14687.1; AT1G14687.
DR KEGG; ath:AT1G14687; -.
DR Araport; AT1G14687; -.
DR TAIR; locus:505006123; AT1G14687.
DR eggNOG; ENOG502SVBY; Eukaryota.
DR HOGENOM; CLU_039237_2_2_1; -.
DR InParanoid; Q9LQW3; -.
DR OMA; RNYHRKV; -.
DR OrthoDB; 1302168at2759; -.
DR PhylomeDB; Q9LQW3; -.
DR PRO; PR:Q9LQW3; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9LQW3; baseline and differential.
DR Genevisible; Q9LQW3; AT.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; ISS:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR006455; Homeodomain_ZF_HD.
DR InterPro; IPR006456; ZF_HD_homeobox_Cys/His_dimer.
DR Pfam; PF04770; ZF-HD_dimer; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR TIGRFAMs; TIGR01565; homeo_ZF_HD; 1.
DR TIGRFAMs; TIGR01566; ZF_HD_prot_N; 1.
DR PROSITE; PS51523; ZF_HD_DIMER; 1.
PE 1: Evidence at protein level;
KW Coiled coil; DNA-binding; Homeobox; Metal-binding; Nucleus;
KW Reference proteome; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..168
FT /note="Zinc-finger homeodomain protein 14"
FT /id="PRO_0000426027"
FT ZN_FING 7..51
FT /note="ZF-HD dimerization-type; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00856"
FT DNA_BIND 106..168
FT /note="Homeobox"
FT REGION 82..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 76..103
FT /evidence="ECO:0000255"
FT SITE 160
FT /note="Required for DNA-binding"
FT /evidence="ECO:0000250"
SQ SEQUENCE 168 AA; 19923 MW; BFB868E8E0A32B94 CRC64;
MQSTCVYREC MRNHAAKLGS YAIDGCREYS QPSTGDLCVA CGCHRSYHRR IDVISSPQIN
HTRFPFTSLR RVKQLARLKW KTAEERNEEE EDDTEETSTE EKMTVQRRRK SKFTAEQREA
MKDYAAKLGW TLKDKRALRE EIRVFCEGIG VTRYHFKTWV NNNKKFYH
