CC184_HUMAN
ID CC184_HUMAN Reviewed; 194 AA.
AC Q52MB2; Q96MK5; Q96N39;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Coiled-coil domain-containing protein 184;
GN Name=CCDC184; Synonyms=C12orf68;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ASP-140.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASP-140.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q52MB2; Q49AR9: ANKS1A; NbExp=3; IntAct=EBI-10179526, EBI-11954519;
CC Q52MB2; O95872: GPANK1; NbExp=6; IntAct=EBI-10179526, EBI-751540;
CC Q52MB2; Q14005-2: IL16; NbExp=3; IntAct=EBI-10179526, EBI-17178971;
CC Q52MB2; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-10179526, EBI-741158;
CC Q52MB2; P30039: PBLD; NbExp=6; IntAct=EBI-10179526, EBI-750589;
CC Q52MB2; Q13526: PIN1; NbExp=6; IntAct=EBI-10179526, EBI-714158;
CC Q52MB2; Q96KQ4: PPP1R13B; NbExp=3; IntAct=EBI-10179526, EBI-1105153;
CC Q52MB2; P32969: RPL9P9; NbExp=6; IntAct=EBI-10179526, EBI-358122;
CC Q52MB2; O75558: STX11; NbExp=6; IntAct=EBI-10179526, EBI-714135;
CC Q52MB2; Q13114: TRAF3; NbExp=3; IntAct=EBI-10179526, EBI-357631;
CC Q52MB2; O00463: TRAF5; NbExp=6; IntAct=EBI-10179526, EBI-523498;
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DR EMBL; AK056003; BAB71071.1; -; mRNA.
DR EMBL; AK056783; BAB71283.1; -; mRNA.
DR EMBL; AC074029; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471111; EAW57977.1; -; Genomic_DNA.
DR EMBL; BC036801; AAH36801.1; -; mRNA.
DR CCDS; CCDS31785.1; -.
DR RefSeq; NP_001013657.3; NM_001013635.3.
DR AlphaFoldDB; Q52MB2; -.
DR BioGRID; 132471; 13.
DR IntAct; Q52MB2; 13.
DR MINT; Q52MB2; -.
DR STRING; 9606.ENSP00000320849; -.
DR iPTMnet; Q52MB2; -.
DR PhosphoSitePlus; Q52MB2; -.
DR BioMuta; CCDC184; -.
DR DMDM; 296434453; -.
DR MassIVE; Q52MB2; -.
DR PaxDb; Q52MB2; -.
DR PeptideAtlas; Q52MB2; -.
DR PRIDE; Q52MB2; -.
DR Antibodypedia; 25636; 74 antibodies from 15 providers.
DR DNASU; 387856; -.
DR Ensembl; ENST00000316554.5; ENSP00000320849.3; ENSG00000177875.5.
DR GeneID; 387856; -.
DR KEGG; hsa:387856; -.
DR MANE-Select; ENST00000316554.5; ENSP00000320849.3; NM_001013635.4; NP_001013657.3.
DR UCSC; uc001rrj.3; human.
DR CTD; 387856; -.
DR GeneCards; CCDC184; -.
DR HGNC; HGNC:33749; CCDC184.
DR HPA; ENSG00000177875; Tissue enhanced (brain).
DR neXtProt; NX_Q52MB2; -.
DR OpenTargets; ENSG00000177875; -.
DR PharmGKB; PA162377998; -.
DR VEuPathDB; HostDB:ENSG00000177875; -.
DR eggNOG; ENOG502RNYW; Eukaryota.
DR GeneTree; ENSGT00390000002978; -.
DR HOGENOM; CLU_125035_0_0_1; -.
DR InParanoid; Q52MB2; -.
DR OMA; HCERSES; -.
DR OrthoDB; 1296471at2759; -.
DR PhylomeDB; Q52MB2; -.
DR TreeFam; TF337201; -.
DR PathwayCommons; Q52MB2; -.
DR SignaLink; Q52MB2; -.
DR BioGRID-ORCS; 387856; 17 hits in 1046 CRISPR screens.
DR GenomeRNAi; 387856; -.
DR Pharos; Q52MB2; Tdark.
DR PRO; PR:Q52MB2; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q52MB2; protein.
DR Bgee; ENSG00000177875; Expressed in cortical plate and 113 other tissues.
DR Genevisible; Q52MB2; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:LIFEdb.
DR InterPro; IPR031458; DUF4677.
DR PANTHER; PTHR31554; PTHR31554; 1.
DR Pfam; PF15726; DUF4677; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Reference proteome.
FT CHAIN 1..194
FT /note="Coiled-coil domain-containing protein 184"
FT /id="PRO_0000335681"
FT REGION 101..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 39..68
FT /evidence="ECO:0000255"
FT VARIANT 140
FT /note="E -> D (in dbSNP:rs10783231)"
FT /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.3"
FT /id="VAR_060278"
FT CONFLICT 78
FT /note="D -> G (in Ref. 1; BAB71071)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 194 AA; 20484 MW; 7281438BCDB2E313 CRC64;
MEDGLLEIMT KDGGDMPAPL EVSTVPAVGD VISGEYNGGM KELMEHLKAQ LQALFEDVRA
MRGALDEQAS HIQVLSDDVC ANQRAIVSMC QIMTTAPRQG GLGVVGGKGS FQSDPQEPET
PSPGIGDSGL LGRDPEDEEE EEEEKEMPSP ATPSSHCERP ESPCAGLLGG DGPLVEPLDM
PDITLLQLEG EASL
