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ZHD1_ARATH
ID   ZHD1_ARATH              Reviewed;         279 AA.
AC   Q9FKP8;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 142.
DE   RecName: Full=Zinc-finger homeodomain protein 1;
DE            Short=AtZHD1;
DE   AltName: Full=Homeobox protein 25;
DE            Short=AtHB-25;
DE   AltName: Full=Zinc finger homeodomain transcription factor 2;
GN   Name=ZHD1; Synonyms=HB25, ZFHD2; OrderedLocusNames=At5g65410;
GN   ORFNames=MNA5.14;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=9679202; DOI=10.1093/dnares/5.2.131;
RA   Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence
RT   features of the regions of 1,381,565 bp covered by twenty one physically
RT   assigned P1 and TAC clones.";
RL   DNA Res. 5:131-145(1998).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   INTERACTION WITH ZHD2; ZHD3; ZHD4; ZHD5; ZHD6; ZHD7; ZHD8; ZHD9; ZHD10 AND
RP   ZHD11, TISSUE SPECIFICITY, AND GENE FAMILY.
RX   PubMed=16428600; DOI=10.1104/pp.105.070565;
RA   Tan Q.K., Irish V.F.;
RT   "The Arabidopsis zinc finger-homeodomain genes encode proteins with unique
RT   biochemical properties that are coordinately expressed during floral
RT   development.";
RL   Plant Physiol. 140:1095-1108(2006).
RN   [5]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=18713354; DOI=10.1111/j.1744-7909.2008.00681.x;
RA   Hu W., dePamphilis C.W., Ma H.;
RT   "Phylogenetic analysis of the plant-specific zinc finger-homeobox and mini
RT   zinc finger gene families.";
RL   J. Integr. Plant Biol. 50:1031-1045(2008).
RN   [6]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19376835; DOI=10.1104/pp.109.138677;
RA   Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,
RA   Grossmann J., Gruissem W., Baginsky S.;
RT   "Large-scale Arabidopsis phosphoproteome profiling reveals novel
RT   chloroplast kinase substrates and phosphorylation networks.";
RL   Plant Physiol. 150:889-903(2009).
RN   [7]
RP   INTERACTION WITH MIF1 AND MIF2, GENE FAMILY, AND NOMENCLATURE.
RC   STRAIN=cv. Columbia;
RX   PubMed=21059647; DOI=10.1074/jbc.m110.167692;
RA   Hong S.-Y., Kim O.-K., Kim S.-G., Yang M.-S., Park C.-M.;
RT   "Nuclear import and DNA binding of the ZHD5 transcription factor is
RT   modulated by a competitive peptide inhibitor in Arabidopsis.";
RL   J. Biol. Chem. 286:1659-1668(2011).
RN   [8]
RP   STRUCTURE BY NMR OF 182-248.
RG   RIKEN structural genomics initiative (RSGI);
RT   "Solution structure of homeobox domain of Arabidopsis thaliana zinc finger
RT   homeobox family protein.";
RL   Submitted (NOV-2004) to the PDB data bank.
CC   -!- FUNCTION: Putative transcription factor.
CC   -!- SUBUNIT: Homo- and heterodimer with other ZFHD proteins (By
CC       similarity). Interacts with MIF1 and MIF2; these interactions prevent
CC       nuclear localization and DNA-binding to inhibit transcription
CC       regulation activity. Binds to ZHD2, ZHD3, ZHD4, ZHD5, ZHD6, ZHD7, ZHD8,
CC       ZHD9, ZHD10 and ZHD11. {ECO:0000250, ECO:0000269|PubMed:16428600,
CC       ECO:0000269|PubMed:21059647}.
CC   -!- INTERACTION:
CC       Q9FKP8; Q9FIW9: ZHD10; NbExp=3; IntAct=EBI-766685, EBI-1806298;
CC       Q9FKP8; Q9LXG0: ZHD8; NbExp=4; IntAct=EBI-766685, EBI-1806405;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Note=Interactions with MIF
CC       proteins prevent nuclear subcellular location and leads to a scattered
CC       repartition throughout the cytoplasm.
CC   -!- TISSUE SPECIFICITY: Mostly expressed in flowers and inflorescence.
CC       {ECO:0000269|PubMed:16428600}.
CC   -!- DOMAIN: The homeodomain differs form the typical one by having namely 4
CC       instead of 3 extra amino acids inserted in the loop between helix 1 and
CC       helix 2.
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DR   EMBL; AB011479; BAB11563.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED98048.1; -; Genomic_DNA.
DR   EMBL; BT002385; AAO00745.1; -; mRNA.
DR   EMBL; BT006304; AAP13412.1; -; mRNA.
DR   RefSeq; NP_201344.1; NM_125939.3.
DR   PDB; 1WH5; NMR; -; A=182-248.
DR   PDBsum; 1WH5; -.
DR   AlphaFoldDB; Q9FKP8; -.
DR   BMRB; Q9FKP8; -.
DR   SMR; Q9FKP8; -.
DR   BioGRID; 21908; 14.
DR   IntAct; Q9FKP8; 13.
DR   STRING; 3702.AT5G65410.1; -.
DR   iPTMnet; Q9FKP8; -.
DR   PaxDb; Q9FKP8; -.
DR   PRIDE; Q9FKP8; -.
DR   ProteomicsDB; 232322; -.
DR   EnsemblPlants; AT5G65410.1; AT5G65410.1; AT5G65410.
DR   GeneID; 836666; -.
DR   Gramene; AT5G65410.1; AT5G65410.1; AT5G65410.
DR   KEGG; ath:AT5G65410; -.
DR   Araport; AT5G65410; -.
DR   TAIR; locus:2168240; AT5G65410.
DR   eggNOG; ENOG502QRG0; Eukaryota.
DR   HOGENOM; CLU_039237_3_1_1; -.
DR   InParanoid; Q9FKP8; -.
DR   OMA; SIGWRIQ; -.
DR   OrthoDB; 1229084at2759; -.
DR   PhylomeDB; Q9FKP8; -.
DR   EvolutionaryTrace; Q9FKP8; -.
DR   PRO; PR:Q9FKP8; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q9FKP8; baseline and differential.
DR   Genevisible; Q9FKP8; AT.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR   GO; GO:0010371; P:regulation of gibberellin biosynthetic process; IMP:TAIR.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:TAIR.
DR   GO; GO:0010431; P:seed maturation; IMP:TAIR.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR006455; Homeodomain_ZF_HD.
DR   InterPro; IPR006456; ZF_HD_homeobox_Cys/His_dimer.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF04770; ZF-HD_dimer; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   TIGRFAMs; TIGR01565; homeo_ZF_HD; 1.
DR   TIGRFAMs; TIGR01566; ZF_HD_prot_N; 1.
DR   PROSITE; PS51523; ZF_HD_DIMER; 1.
PE   1: Evidence at protein level;
KW   3D-structure; DNA-binding; Homeobox; Metal-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..279
FT                   /note="Zinc-finger homeodomain protein 1"
FT                   /id="PRO_0000056847"
FT   ZN_FING         75..124
FT                   /note="ZF-HD dimerization-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00856"
FT   DNA_BIND        191..254
FT                   /note="Homeobox; atypical"
FT   REGION          1..62
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          128..199
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          245..279
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..30
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        43..58
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        131..168
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        258..272
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            243
FT                   /note="Required for DNA-binding"
FT                   /evidence="ECO:0000250"
FT   HELIX           200..213
FT                   /evidence="ECO:0007829|PDB:1WH5"
FT   TURN            219..221
FT                   /evidence="ECO:0007829|PDB:1WH5"
FT   HELIX           222..231
FT                   /evidence="ECO:0007829|PDB:1WH5"
FT   HELIX           236..246
FT                   /evidence="ECO:0007829|PDB:1WH5"
SQ   SEQUENCE   279 AA;  31098 MW;  B9809820DD45B780 CRC64;
     MEFEDNNNNN DEEQEEDMNL HEEEEDDDAV YDSPPLSRVL PKASTESHET TGTTSTGGGG
     GFMVVHGGGG SRFRFRECLK NQAVNIGGHA VDGCGEFMPA GIEGTIDALK CAACGCHRNF
     HRKELPYFHH APPQHQPPPP PPGFYRLPAP VSYRPPPSQA PPLQLALPPP QRERSEDPME
     TSSAEAGGGI RKRHRTKFTA EQKERMLALA ERIGWRIQRQ DDEVIQRFCQ ETGVPRQVLK
     VWLHNNKHTL GKSPSPLHHH QAPPPPPPQS SFHHEQDQP
 
 
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