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ZHD2_ARATH
ID   ZHD2_ARATH              Reviewed;         220 AA.
AC   Q9SB61;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 136.
DE   RecName: Full=Zinc-finger homeodomain protein 2;
DE            Short=AtZHD2;
DE   AltName: Full=Homeobox protein 22;
DE            Short=AtHB-22;
DE   AltName: Full=Protein MATERNAL EFFECT EMBRYO ARREST 68;
GN   Name=ZHD1; Synonyms=HB22, MEE68; OrderedLocusNames=At4g24660;
GN   ORFNames=F22K18.140;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617198; DOI=10.1038/47134;
RA   Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA   Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA   Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA   de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA   Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA   Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA   Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA   Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA   Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA   Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA   Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA   Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA   Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA   Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA   Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA   Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA   Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA   Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA   Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA   Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA   Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA   Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA   Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA   Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA   Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA   Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA   de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA   Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA   Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA   Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA   Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA   Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA   Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA   Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA   Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA   Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA   O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA   Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA   Martienssen R., McCombie W.R.;
RT   "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL   Nature 402:769-777(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   IDENTIFICATION.
RX   PubMed=11289511; DOI=10.1023/a:1006450005648;
RA   Windhoevel A., Hein I., Dabrowa R., Stockhaus J.;
RT   "Characterization of a novel class of plant homeodomain proteins that bind
RT   to the C4 phosphoenolpyruvate carboxylase gene of Flaveria trinervia.";
RL   Plant Mol. Biol. 45:201-214(2001).
RN   [5]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=15634699; DOI=10.1242/dev.01595;
RA   Pagnussat G.C., Yu H.-J., Ngo Q.A., Rajani S., Mayalagu S., Johnson C.S.,
RA   Capron A., Xie L.-F., Ye D., Sundaresan V.;
RT   "Genetic and molecular identification of genes required for female
RT   gametophyte development and function in Arabidopsis.";
RL   Development 132:603-614(2005).
RN   [6]
RP   HOMODIMERIZATION, INTERACTION WITH ZHD1; ZHD3; ZHD4; ZHD5; ZHD6; ZHD7;
RP   ZHD8; ZHD9; ZHD10 AND ZHD11, TISSUE SPECIFICITY, AND GENE FAMILY.
RX   PubMed=16428600; DOI=10.1104/pp.105.070565;
RA   Tan Q.K., Irish V.F.;
RT   "The Arabidopsis zinc finger-homeodomain genes encode proteins with unique
RT   biochemical properties that are coordinately expressed during floral
RT   development.";
RL   Plant Physiol. 140:1095-1108(2006).
RN   [7]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=18713354; DOI=10.1111/j.1744-7909.2008.00681.x;
RA   Hu W., dePamphilis C.W., Ma H.;
RT   "Phylogenetic analysis of the plant-specific zinc finger-homeobox and mini
RT   zinc finger gene families.";
RL   J. Integr. Plant Biol. 50:1031-1045(2008).
RN   [8]
RP   GENE FAMILY, AND NOMENCLATURE.
RC   STRAIN=cv. Columbia;
RX   PubMed=21059647; DOI=10.1074/jbc.m110.167692;
RA   Hong S.-Y., Kim O.-K., Kim S.-G., Yang M.-S., Park C.-M.;
RT   "Nuclear import and DNA binding of the ZHD5 transcription factor is
RT   modulated by a competitive peptide inhibitor in Arabidopsis.";
RL   J. Biol. Chem. 286:1659-1668(2011).
RN   [9]
RP   STRUCTURE BY NMR OF 148-215.
RG   RIKEN structural genomics initiative (RSGI);
RT   "Solution structure of homeobox domain of Arabidopsis thaliana hypothetical
RT   protein F22K18.140.";
RL   Submitted (NOV-2004) to the PDB data bank.
CC   -!- FUNCTION: Essential protein. Putative transcription factor.
CC   -!- SUBUNIT: Homo or heterodimer. Interacts with ZHD1, ZHD3, ZHD4, ZHD5,
CC       ZHD6, ZHD7, ZHD8, ZHD9, ZHD10 and ZHD11. {ECO:0000269|PubMed:16428600}.
CC   -!- INTERACTION:
CC       Q9SB61; Q9LXG0: ZHD8; NbExp=3; IntAct=EBI-1806256, EBI-1806405;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Mostly expressed in flowers and, to a lower extent,
CC       in inflorescence, stems and leaves. {ECO:0000269|PubMed:16428600}.
CC   -!- DOMAIN: The homeodomain differs form the typical one by having namely 4
CC       instead of 3 extra amino acids inserted in the loop between helix 1 and
CC       helix 2.
CC   -!- DISRUPTION PHENOTYPE: Arrested at early embryo stages.
CC       {ECO:0000269|PubMed:15634699}.
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DR   EMBL; AL035356; CAA22997.1; -; Genomic_DNA.
DR   EMBL; AL161561; CAB79376.1; -; Genomic_DNA.
DR   EMBL; CP002687; AEE84939.1; -; Genomic_DNA.
DR   EMBL; AF439841; AAL27510.1; -; mRNA.
DR   EMBL; AY125563; AAM78073.1; -; mRNA.
DR   PIR; T05568; T05568.
DR   RefSeq; NP_194197.1; NM_118599.2.
DR   PDB; 1WH7; NMR; -; A=148-214.
DR   PDBsum; 1WH7; -.
DR   AlphaFoldDB; Q9SB61; -.
DR   BMRB; Q9SB61; -.
DR   SMR; Q9SB61; -.
DR   BioGRID; 13857; 3.
DR   IntAct; Q9SB61; 10.
DR   STRING; 3702.AT4G24660.1; -.
DR   PaxDb; Q9SB61; -.
DR   PRIDE; Q9SB61; -.
DR   ProteomicsDB; 232337; -.
DR   EnsemblPlants; AT4G24660.1; AT4G24660.1; AT4G24660.
DR   GeneID; 828568; -.
DR   Gramene; AT4G24660.1; AT4G24660.1; AT4G24660.
DR   KEGG; ath:AT4G24660; -.
DR   Araport; AT4G24660; -.
DR   TAIR; locus:2121989; AT4G24660.
DR   eggNOG; ENOG502QRG0; Eukaryota.
DR   HOGENOM; CLU_039237_2_2_1; -.
DR   InParanoid; Q9SB61; -.
DR   OMA; ETEIMSG; -.
DR   PhylomeDB; Q9SB61; -.
DR   EvolutionaryTrace; Q9SB61; -.
DR   PRO; PR:Q9SB61; -.
DR   Proteomes; UP000006548; Chromosome 4.
DR   ExpressionAtlas; Q9SB61; baseline and differential.
DR   Genevisible; Q9SB61; AT.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; ISS:TAIR.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0009793; P:embryo development ending in seed dormancy; IMP:TAIR.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR006455; Homeodomain_ZF_HD.
DR   InterPro; IPR006456; ZF_HD_homeobox_Cys/His_dimer.
DR   Pfam; PF04770; ZF-HD_dimer; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   TIGRFAMs; TIGR01565; homeo_ZF_HD; 1.
DR   TIGRFAMs; TIGR01566; ZF_HD_prot_N; 1.
DR   PROSITE; PS51523; ZF_HD_DIMER; 1.
PE   1: Evidence at protein level;
KW   3D-structure; DNA-binding; Homeobox; Metal-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..220
FT                   /note="Zinc-finger homeodomain protein 2"
FT                   /id="PRO_0000056846"
FT   ZN_FING         49..98
FT                   /note="ZF-HD dimerization-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00856"
FT   DNA_BIND        157..220
FT                   /note="Homeobox; atypical"
FT   REGION          1..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          100..160
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        144..160
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            209
FT                   /note="Required for DNA-binding"
FT                   /evidence="ECO:0000250"
FT   HELIX           166..179
FT                   /evidence="ECO:0007829|PDB:1WH7"
FT   HELIX           189..197
FT                   /evidence="ECO:0007829|PDB:1WH7"
FT   HELIX           202..210
FT                   /evidence="ECO:0007829|PDB:1WH7"
SQ   SEQUENCE   220 AA;  24023 MW;  9E8F5BF68AA06897 CRC64;
     MNFEDQEEDM EMSGVNPPCG YDSLSGEGAT SSGGGGVGRS KGVGAKIRYR ECLKNHAVNI
     GGHAVDGCCE FMPSGEDGTL DALKCAACGC HRNFHRKETE SIGGRAHRVP TYYNRPPQPH
     QPPGYLHLTS PAAPYRPPAA SGDEEDTSNP SSSGGTTKRF RTKFTAEQKE KMLAFAERLG
     WRIQKHDDVA VEQFCAETGV RRQVLKIWMH NNKNSLGKKP
 
 
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