ZHD4_ARATH
ID ZHD4_ARATH Reviewed; 312 AA.
AC Q9M9S0;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Zinc-finger homeodomain protein 4;
DE Short=AtZHD4;
DE AltName: Full=Homeobox protein 31;
DE Short=AtHB-31;
DE AltName: Full=Protein FLORAL TRANSITION AT THE MERISTEM 2;
GN Name=ZHD4; Synonyms=FTM2, HB31; OrderedLocusNames=At1g14440;
GN ORFNames=F14L17.21;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Fujita M., Mizukado S., Seki M., Shinozaki K., Mitsuda N., Takiguchi Y.,
RA Takagi M.;
RT "ORF cloning and analysis of Arabidopsis transcription factor genes.";
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP HOMODIMERIZATION, INTERACTION WITH ZHD1; ZHD2; ZHD5; ZHD7; ZHD8; ZHD10 AND
RP ZHD11, TISSUE SPECIFICITY, AND GENE FAMILY.
RX PubMed=16428600; DOI=10.1104/pp.105.070565;
RA Tan Q.K., Irish V.F.;
RT "The Arabidopsis zinc finger-homeodomain genes encode proteins with unique
RT biochemical properties that are coordinately expressed during floral
RT development.";
RL Plant Physiol. 140:1095-1108(2006).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18713354; DOI=10.1111/j.1744-7909.2008.00681.x;
RA Hu W., dePamphilis C.W., Ma H.;
RT "Phylogenetic analysis of the plant-specific zinc finger-homeobox and mini
RT zinc finger gene families.";
RL J. Integr. Plant Biol. 50:1031-1045(2008).
RN [7]
RP GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=21059647; DOI=10.1074/jbc.m110.167692;
RA Hong S.-Y., Kim O.-K., Kim S.-G., Yang M.-S., Park C.-M.;
RT "Nuclear import and DNA binding of the ZHD5 transcription factor is
RT modulated by a competitive peptide inhibitor in Arabidopsis.";
RL J. Biol. Chem. 286:1659-1668(2011).
RN [8]
RP FUNCTION, DEVELOPMENTAL STAGE, AND INDUCTION BY LONG DAYS.
RX PubMed=22319055; DOI=10.1105/tpc.111.092791;
RA Torti S., Fornara F., Vincent C., Andres F., Nordstrom K., Gobel U.,
RA Knoll D., Schoof H., Coupland G.;
RT "Analysis of the Arabidopsis shoot meristem transcriptome during floral
RT transition identifies distinct regulatory patterns and a leucine-rich
RT repeat protein that promotes flowering.";
RL Plant Cell 24:444-462(2012).
CC -!- FUNCTION: Putative transcription factor. Probably involved in the
CC regulation of floral induction. {ECO:0000269|PubMed:22319055}.
CC -!- SUBUNIT: Homo- and heterodimer with other ZFHD proteins. Interacts with
CC ZHD1, ZHD2, ZHD5, ZHD7, ZHD8, ZHD10 and ZHD11.
CC {ECO:0000269|PubMed:16428600}.
CC -!- INTERACTION:
CC Q9M9S0; Q9FIW9: ZHD10; NbExp=4; IntAct=EBI-1806420, EBI-1806298;
CC Q9M9S0; Q9LHF0: ZHD9; NbExp=3; IntAct=EBI-1806420, EBI-1806440;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Mostly expressed in flowers and inflorescence.
CC {ECO:0000269|PubMed:16428600}.
CC -!- DEVELOPMENTAL STAGE: Not detected in the meristem prior to exposure to
CC long days (LDs), but after exposure to three LDs, stable accumulation
CC on the flanks of the meristem adjacent to floral primordia, during
CC floral induction. {ECO:0000269|PubMed:22319055}.
CC -!- INDUCTION: Induced by exposure to long days.
CC {ECO:0000269|PubMed:22319055}.
CC -!- DOMAIN: The homeodomain differs form the typical one by having namely 4
CC instead of 3 extra amino acids inserted in the loop between helix 1 and
CC helix 2.
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DR EMBL; AC012188; AAF43944.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE29163.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE29164.1; -; Genomic_DNA.
DR EMBL; AY074266; AAL66963.1; -; mRNA.
DR EMBL; AY096738; AAM20372.1; -; mRNA.
DR EMBL; AB493456; BAH30294.1; -; mRNA.
DR PIR; A86279; A86279.
DR RefSeq; NP_172896.1; NM_101311.6.
DR RefSeq; NP_973826.1; NM_202097.1.
DR AlphaFoldDB; Q9M9S0; -.
DR SMR; Q9M9S0; -.
DR BioGRID; 23246; 8.
DR IntAct; Q9M9S0; 11.
DR STRING; 3702.AT1G14440.1; -.
DR iPTMnet; Q9M9S0; -.
DR PaxDb; Q9M9S0; -.
DR PRIDE; Q9M9S0; -.
DR ProteomicsDB; 242967; -.
DR EnsemblPlants; AT1G14440.1; AT1G14440.1; AT1G14440.
DR EnsemblPlants; AT1G14440.2; AT1G14440.2; AT1G14440.
DR GeneID; 838006; -.
DR Gramene; AT1G14440.1; AT1G14440.1; AT1G14440.
DR Gramene; AT1G14440.2; AT1G14440.2; AT1G14440.
DR KEGG; ath:AT1G14440; -.
DR Araport; AT1G14440; -.
DR TAIR; locus:2012602; AT1G14440.
DR eggNOG; ENOG502QSB4; Eukaryota.
DR HOGENOM; CLU_039237_2_1_1; -.
DR InParanoid; Q9M9S0; -.
DR OMA; SESEDFM; -.
DR OrthoDB; 1302249at2759; -.
DR PhylomeDB; Q9M9S0; -.
DR PRO; PR:Q9M9S0; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9M9S0; baseline and differential.
DR Genevisible; Q9M9S0; AT.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR GO; GO:0048574; P:long-day photoperiodism, flowering; IEP:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR006455; Homeodomain_ZF_HD.
DR InterPro; IPR006456; ZF_HD_homeobox_Cys/His_dimer.
DR Pfam; PF04770; ZF-HD_dimer; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR TIGRFAMs; TIGR01565; homeo_ZF_HD; 1.
DR TIGRFAMs; TIGR01566; ZF_HD_prot_N; 1.
DR PROSITE; PS51523; ZF_HD_DIMER; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Homeobox; Metal-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..312
FT /note="Zinc-finger homeodomain protein 4"
FT /id="PRO_0000426018"
FT ZN_FING 90..139
FT /note="ZF-HD dimerization-type; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00856"
FT DNA_BIND 218..281
FT /note="Homeobox"
FT REGION 20..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 39..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 270
FT /note="Required for DNA-binding"
FT /evidence="ECO:0000250"
SQ SEQUENCE 312 AA; 35482 MW; 1208117E517C0EE9 CRC64;
MEIASQEDHD MPIPLNTTFG GGGSHGHMIH HHDHHAANSA PPTHNNNNTT QPPPMPLHGN
GHGNNYDHHH HQDPHHVGYN AIIKKPMIKY KECLKNHAAA MGGNATDGCG EFMPSGEDGS
IEALTCSACN CHRNFHRKEV EGELAATAMS PYHQHPPHRK LMLNHQKIRS AMPHQMIMPI
GVSNYRYMHN NSESEDFMEE DGVTTASRSL PNLPYNQKKR FRTKFTPEQK EKMLSFAEKV
GWKIQRQEDC VVQRFCEEIG VKRRVLKVWM HNNKIHFSKK NNINLEDNDN EKINNLNNVD
LSGNNDMTKI VP
