ZHD6_ARATH
ID ZHD6_ARATH Reviewed; 262 AA.
AC Q9ZPW7;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 122.
DE RecName: Full=Zinc-finger homeodomain protein 6;
DE Short=AtZHD6;
DE AltName: Full=Homeobox protein 24;
DE Short=AtHB-24;
GN Name=ZHD6; Synonyms=HB24; OrderedLocusNames=At2g18350; ORFNames=T30D6.14;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP INTERACTION WITH ZHD1; ZHD2; ZHD10 AND ZHD11, TISSUE SPECIFICITY, AND GENE
RP FAMILY.
RX PubMed=16428600; DOI=10.1104/pp.105.070565;
RA Tan Q.K., Irish V.F.;
RT "The Arabidopsis zinc finger-homeodomain genes encode proteins with unique
RT biochemical properties that are coordinately expressed during floral
RT development.";
RL Plant Physiol. 140:1095-1108(2006).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18713354; DOI=10.1111/j.1744-7909.2008.00681.x;
RA Hu W., dePamphilis C.W., Ma H.;
RT "Phylogenetic analysis of the plant-specific zinc finger-homeobox and mini
RT zinc finger gene families.";
RL J. Integr. Plant Biol. 50:1031-1045(2008).
RN [6]
RP INTERACTION WITH MIF1 AND MIF3, GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=21059647; DOI=10.1074/jbc.m110.167692;
RA Hong S.-Y., Kim O.-K., Kim S.-G., Yang M.-S., Park C.-M.;
RT "Nuclear import and DNA binding of the ZHD5 transcription factor is
RT modulated by a competitive peptide inhibitor in Arabidopsis.";
RL J. Biol. Chem. 286:1659-1668(2011).
CC -!- FUNCTION: Putative transcription factor.
CC -!- SUBUNIT: Homo- and heterodimer with other ZFHD proteins (By
CC similarity). Interacts with MIF1 and MIF3; these interactions prevent
CC nuclear localization and DNA-binding to inhibit transcription
CC regulation activity. Binds to ZHD1, ZHD2, ZHD10 and ZHD11.
CC {ECO:0000250, ECO:0000269|PubMed:16428600,
CC ECO:0000269|PubMed:21059647}.
CC -!- INTERACTION:
CC Q9ZPW7; Q9FIW9: ZHD10; NbExp=5; IntAct=EBI-1806363, EBI-1806298;
CC Q9ZPW7; Q9LHF0: ZHD9; NbExp=3; IntAct=EBI-1806363, EBI-1806440;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Interactions with MIF
CC proteins prevent nuclear subcellular location and leads to a scattered
CC repartition throughout the cytoplasm. {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in seedlings, roots, leaves, stems,
CC flowers and inflorescence. {ECO:0000269|PubMed:16428600}.
CC -!- DOMAIN: The homeodomain differs form the typical one by having namely 4
CC instead of 3 extra amino acids inserted in the loop between helix 1 and
CC helix 2.
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DR EMBL; AC006439; AAD15502.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC06760.1; -; Genomic_DNA.
DR EMBL; AY088255; AAM65795.1; -; mRNA.
DR PIR; C84563; C84563.
DR RefSeq; NP_565436.1; NM_127392.1.
DR AlphaFoldDB; Q9ZPW7; -.
DR SMR; Q9ZPW7; -.
DR BioGRID; 1707; 18.
DR IntAct; Q9ZPW7; 19.
DR STRING; 3702.AT2G18350.1; -.
DR iPTMnet; Q9ZPW7; -.
DR PaxDb; Q9ZPW7; -.
DR PRIDE; Q9ZPW7; -.
DR ProteomicsDB; 232307; -.
DR EnsemblPlants; AT2G18350.1; AT2G18350.1; AT2G18350.
DR GeneID; 816350; -.
DR Gramene; AT2G18350.1; AT2G18350.1; AT2G18350.
DR KEGG; ath:AT2G18350; -.
DR Araport; AT2G18350; -.
DR TAIR; locus:2062141; AT2G18350.
DR eggNOG; ENOG502QZSB; Eukaryota.
DR HOGENOM; CLU_039237_2_0_1; -.
DR InParanoid; Q9ZPW7; -.
DR OMA; PRGHMAP; -.
DR OrthoDB; 1185104at2759; -.
DR PhylomeDB; Q9ZPW7; -.
DR PRO; PR:Q9ZPW7; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9ZPW7; baseline and differential.
DR Genevisible; Q9ZPW7; AT.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; ISS:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR006455; Homeodomain_ZF_HD.
DR InterPro; IPR006456; ZF_HD_homeobox_Cys/His_dimer.
DR Pfam; PF04770; ZF-HD_dimer; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR TIGRFAMs; TIGR01565; homeo_ZF_HD; 1.
DR TIGRFAMs; TIGR01566; ZF_HD_prot_N; 1.
DR PROSITE; PS51523; ZF_HD_DIMER; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Homeobox; Metal-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..262
FT /note="Zinc-finger homeodomain protein 6"
FT /id="PRO_0000426020"
FT ZN_FING 82..131
FT /note="ZF-HD dimerization-type; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00856"
FT DNA_BIND 198..261
FT /note="Homeobox"
FT REGION 1..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..81
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 250
FT /note="Required for DNA-binding"
FT /evidence="ECO:0000250"
SQ SEQUENCE 262 AA; 29951 MW; 035EAB17179FC66F CRC64;
MEVREKKDEK MEMTRRKSSA LDHHRLPPYT YSQTANKEKP TTKRNGSDPD PDPDLDTNPI
SISHAPRSYA RPQTTSPGKA RYRECQKNHA ASSGGHVVDG CGEFMSSGEE GTVESLLCAA
CDCHRSFHRK EIDGLFVVNF NSFGHSQRPL GSRHVSPIMM SFGGGGGCAA ESSTEDLNKF
HQSFSGYGVD QFHHYQPKKR FRTKFNEEQK EKMMEFAEKI GWRMTKLEDD EVNRFCREIK
VKRQVFKVWM HNNKQAAKKK DL
