ID   ZHD6_ORYSI              Reviewed;         257 AA.
AC   B8AX53;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Zinc-finger homeodomain protein 6;
GN   Name=ZHD6; ORFNames=OsI_21123;
OS   Oryza sativa subsp. indica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39946;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. 93-11;
RX   PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA   Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA   Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA   Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA   Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA   Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA   Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA   Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA   Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA   Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA   Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA   Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA   Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA   Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA   McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT   "The genomes of Oryza sativa: a history of duplications.";
RL   PLoS Biol. 3:266-281(2005).
CC   -!- FUNCTION: Putative transcription factor. {ECO:0000250}.
CC   -!- SUBUNIT: Homo- and heterodimer with other ZFHD proteins. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- DOMAIN: The homeodomain differs form the typical one by having namely 4
CC       instead of 3 extra amino acids inserted in the loop between helix 1 and
CC       helix 2.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CM000130; EEC79749.1; -; Genomic_DNA.
DR   AlphaFoldDB; B8AX53; -.
DR   SMR; B8AX53; -.
DR   STRING; 39946.B8AX53; -.
DR   PRIDE; B8AX53; -.
DR   EnsemblPlants; BGIOSGA020427-TA; BGIOSGA020427-PA; BGIOSGA020427.
DR   Gramene; BGIOSGA020427-TA; BGIOSGA020427-PA; BGIOSGA020427.
DR   HOGENOM; CLU_039237_3_1_1; -.
DR   OMA; MGVAYGR; -.
DR   Proteomes; UP000007015; Chromosome 5.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR006455; Homeodomain_ZF_HD.
DR   InterPro; IPR006456; ZF_HD_homeobox_Cys/His_dimer.
DR   Pfam; PF04770; ZF-HD_dimer; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   TIGRFAMs; TIGR01565; homeo_ZF_HD; 1.
DR   TIGRFAMs; TIGR01566; ZF_HD_prot_N; 1.
DR   PROSITE; PS51523; ZF_HD_DIMER; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Homeobox; Metal-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..257
FT                   /note="Zinc-finger homeodomain protein 6"
FT                   /id="PRO_0000426044"
FT   ZN_FING         45..93
FT                   /note="ZF-HD dimerization-type; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00856"
FT   DNA_BIND        174..237
FT                   /note="Homeobox"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          106..182
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          228..257
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        19..33
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        107..140
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        145..164
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            226
FT                   /note="Required for DNA-binding"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   257 AA;  28094 MW;  DE88945179DDA942 CRC64;
     MEFRGHDEPV DEMGVAYGRT PPSSSSSPAA SASAGNGAGA AEVRYHECLR NHAAAMGGHV
     VDGCGEFMPM PGDAADALKC AACGCHRSFH RKDDGQQQQQ LRLLIPSPPT PRVPLLMPPP
     QPQPHPHPHP QHPYLHPPFP YHHTPSGSGG TTTESSSEER GPPSSSAAAA QGRRKRFRTK
     FTPEQKEQML AFAERVGWRM QKQDEALVEQ FCAQVGVRRQ VFKVWMHNNK SSIGSSSGGG
     SRRQPQEQQS QQQQQQQ