ZHD7_ARATH
ID ZHD7_ARATH Reviewed; 249 AA.
AC Q9SVL0; Q8LDG1;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Zinc-finger homeodomain protein 7;
DE Short=AtZHD7;
DE AltName: Full=Homeobox protein 28;
DE Short=AtHB-28;
GN Name=ZHD7; Synonyms=HB28; OrderedLocusNames=At3g50890; ORFNames=F18B3.170;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP INTERACTION WITH ZHD1; ZHD2; ZHD4; ZHD10 AND ZHD11, TISSUE SPECIFICITY, AND
RP GENE FAMILY.
RX PubMed=16428600; DOI=10.1104/pp.105.070565;
RA Tan Q.K., Irish V.F.;
RT "The Arabidopsis zinc finger-homeodomain genes encode proteins with unique
RT biochemical properties that are coordinately expressed during floral
RT development.";
RL Plant Physiol. 140:1095-1108(2006).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18713354; DOI=10.1111/j.1744-7909.2008.00681.x;
RA Hu W., dePamphilis C.W., Ma H.;
RT "Phylogenetic analysis of the plant-specific zinc finger-homeobox and mini
RT zinc finger gene families.";
RL J. Integr. Plant Biol. 50:1031-1045(2008).
RN [7]
RP INTERACTION WITH MIF1 AND MIF3, GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=21059647; DOI=10.1074/jbc.m110.167692;
RA Hong S.-Y., Kim O.-K., Kim S.-G., Yang M.-S., Park C.-M.;
RT "Nuclear import and DNA binding of the ZHD5 transcription factor is
RT modulated by a competitive peptide inhibitor in Arabidopsis.";
RL J. Biol. Chem. 286:1659-1668(2011).
CC -!- FUNCTION: Putative transcription factor.
CC -!- SUBUNIT: Homo- and heterodimer with other ZFHD proteins (By
CC similarity). Interacts with MIF1 and MIF3; these interactions prevent
CC nuclear localization and DNA-binding to inhibit transcription
CC regulation activity. Binds to ZHD1, ZHD2, ZHD4, ZHD10 and ZHD11.
CC {ECO:0000250, ECO:0000269|PubMed:16428600,
CC ECO:0000269|PubMed:21059647}.
CC -!- INTERACTION:
CC Q9SVL0; O24409: IAA19; NbExp=3; IntAct=EBI-1806382, EBI-632257;
CC Q9SVL0; O24410: IAA20; NbExp=3; IntAct=EBI-1806382, EBI-632272;
CC Q9SVL0; Q9FIW9: ZHD10; NbExp=5; IntAct=EBI-1806382, EBI-1806298;
CC Q9SVL0; Q9FRL5: ZHD5; NbExp=3; IntAct=EBI-1806382, EBI-1806169;
CC Q9SVL0; Q9LXG0: ZHD8; NbExp=4; IntAct=EBI-1806382, EBI-1806405;
CC Q9SVL0; Q9LHF0: ZHD9; NbExp=3; IntAct=EBI-1806382, EBI-1806440;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC Note=Interactions with MIF proteins prevent nuclear subcellular
CC location and leads to a scattered repartition throughout the cytoplasm.
CC {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Mostly expressed in flowers and inflorescence.
CC {ECO:0000269|PubMed:16428600}.
CC -!- DOMAIN: The homeodomain differs form the typical one by having namely 4
CC instead of 3 extra amino acids inserted in the loop between helix 1 and
CC helix 2.
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DR EMBL; AL049862; CAB42918.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE78722.1; -; Genomic_DNA.
DR EMBL; AK175649; BAD43412.1; -; mRNA.
DR EMBL; AY086020; AAM63229.1; -; mRNA.
DR PIR; T08410; T08410.
DR RefSeq; NP_190658.1; NM_114949.2.
DR AlphaFoldDB; Q9SVL0; -.
DR SMR; Q9SVL0; -.
DR BioGRID; 9571; 19.
DR IntAct; Q9SVL0; 18.
DR STRING; 3702.AT3G50890.1; -.
DR iPTMnet; Q9SVL0; -.
DR PaxDb; Q9SVL0; -.
DR PRIDE; Q9SVL0; -.
DR ProteomicsDB; 242350; -.
DR EnsemblPlants; AT3G50890.1; AT3G50890.1; AT3G50890.
DR GeneID; 824253; -.
DR Gramene; AT3G50890.1; AT3G50890.1; AT3G50890.
DR KEGG; ath:AT3G50890; -.
DR Araport; AT3G50890; -.
DR TAIR; locus:2077957; AT3G50890.
DR eggNOG; ENOG502QZSB; Eukaryota.
DR HOGENOM; CLU_039237_2_2_1; -.
DR InParanoid; Q9SVL0; -.
DR OMA; CCEFMAG; -.
DR OrthoDB; 1185104at2759; -.
DR PhylomeDB; Q9SVL0; -.
DR PRO; PR:Q9SVL0; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9SVL0; baseline and differential.
DR Genevisible; Q9SVL0; AT.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; ISS:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR006455; Homeodomain_ZF_HD.
DR InterPro; IPR006456; ZF_HD_homeobox_Cys/His_dimer.
DR Pfam; PF04770; ZF-HD_dimer; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR TIGRFAMs; TIGR01565; homeo_ZF_HD; 1.
DR TIGRFAMs; TIGR01566; ZF_HD_prot_N; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS51523; ZF_HD_DIMER; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Homeobox; Metal-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..249
FT /note="Zinc-finger homeodomain protein 7"
FT /id="PRO_0000426021"
FT ZN_FING 60..109
FT /note="ZF-HD dimerization-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00856"
FT DNA_BIND 181..244
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 11..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 134..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 233
FT /note="Required for DNA-binding"
FT /evidence="ECO:0000250"
FT CONFLICT 15
FT /note="M -> I (in Ref. 4; AAM63229)"
FT /evidence="ECO:0000305"
FT CONFLICT 114
FT /note="R -> M (in Ref. 4; AAM63229)"
FT /evidence="ECO:0000305"
FT CONFLICT 120
FT /note="H -> Y (in Ref. 4; AAM63229)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 249 AA; 28658 MW; F0C163A282D51BB4 CRC64;
MELGGKCNAI TTTTMISTEV KPHTDPEPEA KPESDPSMAL FPIKKENQKP KTRVDQGAKY
RECQKNHAAS TGGHVVDGCC EFMAGGEEGT LGALKCAACN CHRSFHRKEV YGHRNSKQDH
QLMITPAFYS SNSSYKPRVM HPTGEIGRRT SSSSEDMKKI LSHRNQNVDG KSLMMMMMRK
KKRVRTKINE EQKEKMKEFA ERLGWRMQKK DEEEIDKFCR MVNLRRQVFK VWMHNNKQAM
KRNNSNISE
