ZHX1R_HUMAN
ID ZHX1R_HUMAN Reviewed; 292 AA.
AC Q96EF9;
DT 21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Zinc fingers and homeoboxes protein 1, isoform 2;
DE AltName: Full=ZHX1-C8orf76 readthrough transcript protein;
GN Name=ZHX1-C8orf76; Synonyms=C8orf76;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q96EF9; P04083: ANXA1; NbExp=3; IntAct=EBI-25830993, EBI-354007;
CC Q96EF9; Q92870-2: APBB2; NbExp=3; IntAct=EBI-25830993, EBI-21535880;
CC Q96EF9; Q86V38: ATN1; NbExp=3; IntAct=EBI-25830993, EBI-11954292;
CC Q96EF9; P27797: CALR; NbExp=3; IntAct=EBI-25830993, EBI-1049597;
CC Q96EF9; P12830: CDH1; NbExp=3; IntAct=EBI-25830993, EBI-727477;
CC Q96EF9; P02489: CRYAA; NbExp=3; IntAct=EBI-25830993, EBI-6875961;
CC Q96EF9; P36957: DLST; NbExp=3; IntAct=EBI-25830993, EBI-351007;
CC Q96EF9; Q14204: DYNC1H1; NbExp=3; IntAct=EBI-25830993, EBI-356015;
CC Q96EF9; P00488: F13A1; NbExp=3; IntAct=EBI-25830993, EBI-2565863;
CC Q96EF9; O14908-2: GIPC1; NbExp=3; IntAct=EBI-25830993, EBI-25913156;
CC Q96EF9; P42858: HTT; NbExp=18; IntAct=EBI-25830993, EBI-466029;
CC Q96EF9; Q8TDX7: NEK7; NbExp=3; IntAct=EBI-25830993, EBI-1055945;
CC Q96EF9; Q96CV9: OPTN; NbExp=3; IntAct=EBI-25830993, EBI-748974;
CC Q96EF9; Q13153: PAK1; NbExp=3; IntAct=EBI-25830993, EBI-1307;
CC Q96EF9; D3DTS7: PMP22; NbExp=3; IntAct=EBI-25830993, EBI-25882629;
CC Q96EF9; Q8N131: TMEM123; NbExp=3; IntAct=EBI-25830993, EBI-749248;
CC Q96EF9; Q8IUH5: ZDHHC17; NbExp=3; IntAct=EBI-25830993, EBI-524753;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=2; Synonyms=ZHX1-C8orf76;
CC IsoId=Q96EF9-1; Sequence=Displayed;
CC Name=1;
CC IsoId=Q9UKY1-1; Sequence=External;
CC Name=3;
CC IsoId=Q96K31-1; Sequence=External;
CC -!- MISCELLANEOUS: [Isoform 2]: Based on a readthrough transcript which may
CC produce a ZHX1-C8orf76 fusion protein.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC068228; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC012379; AAH12379.1; -; mRNA.
DR CCDS; CCDS56552.1; -. [Q96EF9-1]
DR RefSeq; NP_001191109.1; NM_001204180.1. [Q96EF9-1]
DR AlphaFoldDB; Q96EF9; -.
DR SMR; Q96EF9; -.
DR BioGRID; 1529420; 26.
DR IntAct; Q96EF9; 17.
DR STRING; 9606.ENSP00000481928; -.
DR iPTMnet; Q96EF9; -.
DR BioMuta; ZHX1-C8orf76; -.
DR DMDM; 74731558; -.
DR EPD; Q96EF9; -.
DR jPOST; Q96EF9; -.
DR MassIVE; Q96EF9; -.
DR PaxDb; Q96EF9; -.
DR PeptideAtlas; Q96EF9; -.
DR PRIDE; Q96EF9; -.
DR Antibodypedia; 77359; 24 antibodies from 4 providers.
DR Ensembl; ENST00000357082.8; ENSP00000349593.4; ENSG00000259305.6. [Q96EF9-1]
DR GeneID; 100533106; -.
DR KEGG; hsa:100533106; -.
DR UCSC; uc003yqd.4; human. [Q96EF9-1]
DR CTD; 100533106; -.
DR GeneCards; ZHX1-C8orf76; -.
DR HGNC; HGNC:42975; ZHX1-C8orf76.
DR HPA; ENSG00000259305; Low tissue specificity.
DR neXtProt; NX_Q96EF9; -.
DR VEuPathDB; HostDB:ENSG00000259305; -.
DR eggNOG; ENOG502QW95; Eukaryota.
DR GeneTree; ENSGT00390000011435; -.
DR HOGENOM; CLU_044858_0_0_1; -.
DR InParanoid; Q96EF9; -.
DR OMA; WFCEASA; -.
DR OrthoDB; 113584at2759; -.
DR PhylomeDB; Q96EF9; -.
DR TreeFam; TF332319; -.
DR PathwayCommons; Q96EF9; -.
DR BioGRID-ORCS; 100533106; 4 hits in 567 CRISPR screens.
DR ChiTaRS; ZHX1-C8orf76; human.
DR GenomeRNAi; 100533106; -.
DR Pharos; Q96EF9; Tdark.
DR PRO; PR:Q96EF9; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q96EF9; protein.
DR Bgee; ENSG00000259305; Expressed in bone marrow and 94 other tissues.
DR ExpressionAtlas; Q96EF9; baseline and differential.
DR Genevisible; Q96EF9; HS.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR041404; DUF5588.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR31919; PTHR31919; 1.
DR Pfam; PF17826; DUF5588; 1.
DR SUPFAM; SSF48452; SSF48452; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..292
FT /note="Zinc fingers and homeoboxes protein 1, isoform 2"
FT /id="PRO_0000415939"
SQ SEQUENCE 292 AA; 33285 MW; 3F5E55E9C6F23D93 CRC64;
MLRKLWQWFY EETESSDDVE VLTLKKFKGD LAYRRQEYQK ALQEYSSISE KLSSTNFAMK
RDVQEGQARC LAHLGRHMEA LEIAANLENK ATNTDHLTTV LYLQLAICSS LQNLEKTIFC
LQKLISLHPF NPWNWGKLAE AYLNLGPALS AALASSQKQH SFTSSDKTIK SFFPHSGKDC
LLCFPETLPE SSLFSVEANS SNSQKNEKAL TNIQNCMAEK RETVLIETQL KACASFIRTR
LLLQFTQPQQ TSFALERNLR TQQEIEDKMK GFSFKEDTLL LIAEVSVSLG FM
