CC185_HUMAN
ID CC185_HUMAN Reviewed; 623 AA.
AC Q8N715; Q8N746; Q8NA93;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Coiled-coil domain-containing protein 185;
GN Name=CCDC185; Synonyms=C1orf65;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS ASP-329 AND LEU-380.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-528, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25218447; DOI=10.1038/nsmb.2890;
RA Hendriks I.A., D'Souza R.C., Yang B., Verlaan-de Vries M., Mann M.,
RA Vertegaal A.C.;
RT "Uncovering global SUMOylation signaling networks in a site-specific
RT manner.";
RL Nat. Struct. Mol. Biol. 21:927-936(2014).
CC -!- INTERACTION:
CC Q8N715; Q9Y2J4: AMOTL2; NbExp=3; IntAct=EBI-740814, EBI-746752;
CC Q8N715; Q9BYV9: BACH2; NbExp=3; IntAct=EBI-740814, EBI-1642333;
CC Q8N715; A2RRN7: CADPS; NbExp=3; IntAct=EBI-740814, EBI-10179719;
CC Q8N715; Q8NA61-2: CBY2; NbExp=3; IntAct=EBI-740814, EBI-11524851;
CC Q8N715; Q86X02: CDR2L; NbExp=3; IntAct=EBI-740814, EBI-11063830;
CC Q8N715; Q9C0F1: CEP44; NbExp=5; IntAct=EBI-740814, EBI-744115;
CC Q8N715; Q86XR8-3: CEP57; NbExp=3; IntAct=EBI-740814, EBI-11752486;
CC Q8N715; O60447: EVI5; NbExp=3; IntAct=EBI-740814, EBI-852291;
CC Q8N715; Q96CN4: EVI5L; NbExp=3; IntAct=EBI-740814, EBI-749523;
CC Q8N715; Q3B820: FAM161A; NbExp=3; IntAct=EBI-740814, EBI-719941;
CC Q8N715; P57678: GEMIN4; NbExp=3; IntAct=EBI-740814, EBI-356700;
CC Q8N715; Q08379: GOLGA2; NbExp=3; IntAct=EBI-740814, EBI-618309;
CC Q8N715; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-740814, EBI-5916454;
CC Q8N715; Q4V328: GRIPAP1; NbExp=3; IntAct=EBI-740814, EBI-717919;
CC Q8N715; O75031: HSF2BP; NbExp=3; IntAct=EBI-740814, EBI-7116203;
CC Q8N715; Q13422-7: IKZF1; NbExp=3; IntAct=EBI-740814, EBI-11522367;
CC Q8N715; Q9ULR0-1: ISY1; NbExp=3; IntAct=EBI-740814, EBI-18398632;
CC Q8N715; Q7Z3Y8: KRT27; NbExp=3; IntAct=EBI-740814, EBI-3044087;
CC Q8N715; Q92764: KRT35; NbExp=3; IntAct=EBI-740814, EBI-1058674;
CC Q8N715; Q6A162: KRT40; NbExp=6; IntAct=EBI-740814, EBI-10171697;
CC Q8N715; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-740814, EBI-10172290;
CC Q8N715; P43356: MAGEA2B; NbExp=3; IntAct=EBI-740814, EBI-5650739;
CC Q8N715; P43360: MAGEA6; NbExp=3; IntAct=EBI-740814, EBI-1045155;
CC Q8N715; P23508: MCC; NbExp=3; IntAct=EBI-740814, EBI-307531;
CC Q8N715; Q99750: MDFI; NbExp=4; IntAct=EBI-740814, EBI-724076;
CC Q8N715; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-740814, EBI-10172526;
CC Q8N715; Q13064: MKRN3; NbExp=3; IntAct=EBI-740814, EBI-2340269;
CC Q8N715; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-740814, EBI-11522433;
CC Q8N715; Q9ULW6: NAP1L2; NbExp=3; IntAct=EBI-740814, EBI-3911716;
CC Q8N715; Q96KN3: PKNOX2; NbExp=3; IntAct=EBI-740814, EBI-2692890;
CC Q8N715; Q9BZL4: PPP1R12C; NbExp=3; IntAct=EBI-740814, EBI-721802;
CC Q8N715; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-740814, EBI-5235340;
CC Q8N715; P02549: SPTA1; NbExp=3; IntAct=EBI-740814, EBI-375617;
CC Q8N715; Q86TI0: TBC1D1; NbExp=3; IntAct=EBI-740814, EBI-1644036;
CC Q8N715; Q13077: TRAF1; NbExp=3; IntAct=EBI-740814, EBI-359224;
CC Q8N715; P14373: TRIM27; NbExp=3; IntAct=EBI-740814, EBI-719493;
CC Q8N715; Q8N1B4: VPS52; NbExp=3; IntAct=EBI-740814, EBI-2799833;
CC Q8N715; Q9UGI0: ZRANB1; NbExp=3; IntAct=EBI-740814, EBI-527853;
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DR EMBL; AK093047; BAC04033.1; -; mRNA.
DR EMBL; AL590669; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC030026; AAH30026.1; -; mRNA.
DR EMBL; BC031066; AAH31066.1; -; mRNA.
DR CCDS; CCDS1537.1; -.
DR RefSeq; NP_689823.2; NM_152610.2.
DR AlphaFoldDB; Q8N715; -.
DR SMR; Q8N715; -.
DR BioGRID; 127889; 59.
DR IntAct; Q8N715; 49.
DR STRING; 9606.ENSP00000355840; -.
DR iPTMnet; Q8N715; -.
DR PhosphoSitePlus; Q8N715; -.
DR BioMuta; CCDC185; -.
DR DMDM; 296434417; -.
DR EPD; Q8N715; -.
DR MassIVE; Q8N715; -.
DR PaxDb; Q8N715; -.
DR PeptideAtlas; Q8N715; -.
DR PRIDE; Q8N715; -.
DR ProteomicsDB; 72254; -.
DR Antibodypedia; 20747; 55 antibodies from 14 providers.
DR DNASU; 164127; -.
DR Ensembl; ENST00000366875.5; ENSP00000355840.3; ENSG00000178395.7.
DR GeneID; 164127; -.
DR KEGG; hsa:164127; -.
DR MANE-Select; ENST00000366875.5; ENSP00000355840.3; NM_152610.3; NP_689823.2.
DR UCSC; uc001hoa.3; human.
DR CTD; 164127; -.
DR GeneCards; CCDC185; -.
DR HGNC; HGNC:26654; CCDC185.
DR HPA; ENSG00000178395; Tissue enriched (testis).
DR neXtProt; NX_Q8N715; -.
DR OpenTargets; ENSG00000178395; -.
DR PharmGKB; PA142672515; -.
DR VEuPathDB; HostDB:ENSG00000178395; -.
DR eggNOG; ENOG502RZUY; Eukaryota.
DR GeneTree; ENSGT00740000115684; -.
DR HOGENOM; CLU_029998_0_0_1; -.
DR InParanoid; Q8N715; -.
DR OMA; DQWAVPV; -.
DR OrthoDB; 474796at2759; -.
DR PhylomeDB; Q8N715; -.
DR TreeFam; TF337827; -.
DR PathwayCommons; Q8N715; -.
DR SignaLink; Q8N715; -.
DR BioGRID-ORCS; 164127; 13 hits in 1042 CRISPR screens.
DR GenomeRNAi; 164127; -.
DR Pharos; Q8N715; Tdark.
DR PRO; PR:Q8N715; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8N715; protein.
DR Bgee; ENSG00000178395; Expressed in left testis and 26 other tissues.
DR Genevisible; Q8N715; HS.
DR InterPro; IPR029090; DUF4659.
DR PANTHER; PTHR33663; PTHR33663; 1.
DR Pfam; PF15558; DUF4659; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Isopeptide bond; Reference proteome; Ubl conjugation.
FT CHAIN 1..623
FT /note="Coiled-coil domain-containing protein 185"
FT /id="PRO_0000247114"
FT REGION 1..242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 314..376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 574..607
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 266..295
FT /evidence="ECO:0000255"
FT COILED 359..392
FT /evidence="ECO:0000255"
FT COILED 431..501
FT /evidence="ECO:0000255"
FT COILED 534..573
FT /evidence="ECO:0000255"
FT COMPBIAS 29..47
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..153
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 210..238
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 528
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:25218447"
FT VARIANT 195
FT /note="V -> A (in dbSNP:rs6689850)"
FT /id="VAR_027066"
FT VARIANT 329
FT /note="G -> D (in dbSNP:rs10907376)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_027067"
FT VARIANT 331
FT /note="R -> W (in dbSNP:rs6682552)"
FT /id="VAR_027068"
FT VARIANT 380
FT /note="R -> L (in dbSNP:rs17852896)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_027069"
SQ SEQUENCE 623 AA; 72349 MW; 19103B45552CE57C CRC64;
MAGFSHFSQP PYRDLWEPPR PGGERESTQR LGGQRSGADS TACSRAGTPG AESEAGACWL
HPHCSFTPRP RRRGCSDSLR GSRSLSDVAR RPLERSRKHR PRSRRLEDAW GETGTKPRPA
WQPQTQLPPQ RPQPCPHYPL AQGDSPPPCP GGAGTPLSGT FRVEKAQGGD QWAVPLGRHL
GRWSPSSVPS ERSSVPSQKF KRHSACVCAQ KRDSSDQVES LASRDSQPLA SSKEMRSPHT
QVLKSKLEEV VVSSQDQQIV ALVLTRLKKA QRIRELQQQA AKAWEELKRS DQKVQMTLER
ERRLLLRQSQ EQWQEKEQRK TLQSPEQRGL RRDSQRKNVP PGESRWKEQP EDQESPRQEK
LEKARAQAEH RKQCQVRRLR EQEKMLRNLR EQHSLQLQRR LVEACRKRHL HAVEGQKKVQ
DTNLSSLINY QARKVLMDCQ AKAEELLRQL SLEQSFQRSQ EIHQGLRKER QRELREKAQK
EEEQLQQARW RAGESEEQRK MRKRILVELA DEKIRQARSH VHKTTRDKVQ HLRELNHLRE
KNHHILKLKA EKEEKCHIEG IKEAIKKKEQ RVQHISQGKD PNFQEFQKLP QASRREERAP
PNSSLDQMVL EAQLRACQQN RGY
