CC186_HUMAN
ID CC186_HUMAN Reviewed; 898 AA.
AC Q7Z3E2; Q2M2V6; Q3ZB81; Q6NS91; Q7RTP1; Q8N117; Q8N3G3; Q8N6C2; Q9NWA3;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 2.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Coiled-coil domain-containing protein 186;
DE AltName: Full=CTCL tumor antigen HD-CL-01/L14-2;
GN Name=CCDC186; Synonyms=C10orf118;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LYS-271.
RC TISSUE=Endometrial tumor, and Melanoma;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS ILE-85 AND LYS-271.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 74-791, AND VARIANTS ILE-85; GLN-179 AND
RP LYS-271.
RC TISSUE=Lymphoma;
RX PubMed=14996095; DOI=10.1111/j.1365-2133.2004.05651.x;
RA Hartmann T.B., Thiel D., Dummer R., Schadendorf D., Eichmueller S.;
RT "SEREX identification of new tumour-associated antigens in cutaneous T-cell
RT lymphoma.";
RL Br. J. Dermatol. 150:252-258(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 614-898.
RC TISSUE=Embryo, and Prostate;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP IDENTIFICATION.
RX PubMed=12783626; DOI=10.1186/1471-2164-4-22;
RA Oduru S., Campbell J.L., Karri S., Hendry W.J., Khan S.A., Williams S.C.;
RT "Gene discovery in the hamster: a comparative genomics approach for gene
RT annotation by sequencing of hamster testis cDNAs.";
RL BMC Genomics 4:22-22(2003).
RN [6]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, CLEAVAGE OF INITIATOR
RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH70368.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 212.; Evidence={ECO:0000305};
CC Sequence=AAM44457.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAM44457.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 792.; Evidence={ECO:0000305};
CC Sequence=BAA91480.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC03926.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
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DR EMBL; AL834368; CAD39031.2; -; mRNA.
DR EMBL; BX537964; CAD97928.1; -; mRNA.
DR EMBL; BC070368; AAH70368.1; ALT_SEQ; mRNA.
DR EMBL; BC103499; AAI03500.1; -; mRNA.
DR EMBL; BC105632; AAI05633.1; -; mRNA.
DR EMBL; BC152306; AAI52307.1; -; mRNA.
DR EMBL; AF273054; AAM44457.1; ALT_SEQ; mRNA.
DR EMBL; AK001050; BAA91480.1; ALT_INIT; mRNA.
DR EMBL; AK092620; BAC03926.1; ALT_SEQ; mRNA.
DR EMBL; BK001329; DAA01463.1; -; mRNA.
DR CCDS; CCDS7587.1; -.
DR RefSeq; NP_001308758.1; NM_001321829.1.
DR RefSeq; NP_060487.2; NM_018017.3.
DR RefSeq; NP_694981.1; NM_153249.1.
DR AlphaFoldDB; Q7Z3E2; -.
DR SMR; Q7Z3E2; -.
DR BioGRID; 120401; 28.
DR DIP; DIP-47298N; -.
DR IntAct; Q7Z3E2; 18.
DR MINT; Q7Z3E2; -.
DR STRING; 9606.ENSP00000358293; -.
DR GlyGen; Q7Z3E2; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q7Z3E2; -.
DR PhosphoSitePlus; Q7Z3E2; -.
DR BioMuta; CCDC186; -.
DR DMDM; 71152997; -.
DR EPD; Q7Z3E2; -.
DR jPOST; Q7Z3E2; -.
DR MassIVE; Q7Z3E2; -.
DR MaxQB; Q7Z3E2; -.
DR PaxDb; Q7Z3E2; -.
DR PeptideAtlas; Q7Z3E2; -.
DR PRIDE; Q7Z3E2; -.
DR ProteomicsDB; 69040; -.
DR Antibodypedia; 2907; 29 antibodies from 10 providers.
DR DNASU; 55088; -.
DR Ensembl; ENST00000369287.8; ENSP00000358293.3; ENSG00000165813.20.
DR Ensembl; ENST00000648613.1; ENSP00000498136.1; ENSG00000165813.20.
DR GeneID; 55088; -.
DR KEGG; hsa:55088; -.
DR MANE-Select; ENST00000369287.8; ENSP00000358293.3; NM_018017.4; NP_060487.2.
DR UCSC; uc001lbb.2; human.
DR CTD; 55088; -.
DR DisGeNET; 55088; -.
DR GeneCards; CCDC186; -.
DR HGNC; HGNC:24349; CCDC186.
DR HPA; ENSG00000165813; Low tissue specificity.
DR MIM; 619249; gene.
DR neXtProt; NX_Q7Z3E2; -.
DR OpenTargets; ENSG00000165813; -.
DR PharmGKB; PA134904295; -.
DR VEuPathDB; HostDB:ENSG00000165813; -.
DR eggNOG; KOG0992; Eukaryota.
DR eggNOG; KOG1836; Eukaryota.
DR GeneTree; ENSGT00720000108851; -.
DR HOGENOM; CLU_007958_0_0_1; -.
DR InParanoid; Q7Z3E2; -.
DR OMA; QEHTIKR; -.
DR OrthoDB; 604365at2759; -.
DR PhylomeDB; Q7Z3E2; -.
DR TreeFam; TF328785; -.
DR PathwayCommons; Q7Z3E2; -.
DR SignaLink; Q7Z3E2; -.
DR BioGRID-ORCS; 55088; 10 hits in 1063 CRISPR screens.
DR ChiTaRS; CCDC186; human.
DR GeneWiki; C10orf118; -.
DR GenomeRNAi; 55088; -.
DR Pharos; Q7Z3E2; Tdark.
DR PRO; PR:Q7Z3E2; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q7Z3E2; protein.
DR Bgee; ENSG00000165813; Expressed in sperm and 178 other tissues.
DR ExpressionAtlas; Q7Z3E2; baseline and differential.
DR Genevisible; Q7Z3E2; HS.
DR GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR GO; GO:0031267; F:small GTPase binding; IBA:GO_Central.
DR GO; GO:0035773; P:insulin secretion involved in cellular response to glucose stimulus; IEA:Ensembl.
DR GO; GO:0009617; P:response to bacterium; IEA:Ensembl.
DR GO; GO:0099518; P:vesicle cytoskeletal trafficking; IBA:GO_Central.
DR InterPro; IPR038830; CCDC186.
DR PANTHER; PTHR18911; PTHR18911; 1.
PE 1: Evidence at protein level;
KW Acetylation; Coiled coil; Phosphoprotein; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0007744|PubMed:19413330"
FT CHAIN 2..898
FT /note="Coiled-coil domain-containing protein 186"
FT /id="PRO_0000089823"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 68..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 702..749
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 201..712
FT /evidence="ECO:0000255"
FT COILED 759..803
FT /evidence="ECO:0000255"
FT COILED 855..894
FT /evidence="ECO:0000255"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..43
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 712..749
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0007744|PubMed:19413330"
FT MOD_RES 740
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8C9S4"
FT VARIANT 85
FT /note="T -> I (in dbSNP:rs1061159)"
FT /evidence="ECO:0000269|PubMed:14996095,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_023047"
FT VARIANT 179
FT /note="R -> Q (in dbSNP:rs12782946)"
FT /evidence="ECO:0000269|PubMed:14996095"
FT /id="VAR_023048"
FT VARIANT 271
FT /note="Q -> K (in dbSNP:rs7095762)"
FT /evidence="ECO:0000269|PubMed:14996095,
FT ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:17974005"
FT /id="VAR_023049"
FT CONFLICT 74..76
FT /note="GGG -> IRH (in Ref. 3; AAM44457)"
FT /evidence="ECO:0000305"
FT CONFLICT 209
FT /note="I -> T (in Ref. 2; AAH70368)"
FT /evidence="ECO:0000305"
FT CONFLICT 614
FT /note="D -> I (in Ref. 4; BAA91480)"
FT /evidence="ECO:0000305"
FT CONFLICT 745
FT /note="G -> E (in Ref. 1; CAD39031)"
FT /evidence="ECO:0000305"
FT CONFLICT 857
FT /note="Q -> L (in Ref. 1; CAD97928)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 898 AA; 103687 MW; 47E8A9BD547C82D3 CRC64;
MSETDHIAST SSDKNVGKTP ELKEDSCNLF SGNESSKLEN ESKLLSLNTD KTLCQPNEHN
NRIEAQENYI PDHGGGEDSC AKTDTGSENS EQIANFPSGN FAKHISKTNE TEQKVTQILV
ELRSSTFPES ANEKTYSESP YDTDCTKKFI SKIKSVSASE DLLEEIESEL LSTEFAEHRV
PNGMNKGEHA LVLFEKCVQD KYLQQEHIIK KLIKENKKHQ ELFVDICSEK DNLREELKKR
TETEKQHMNT IKQLESRIEE LNKEVKASRD QLIAQDVTAK NAVQQLHKEM AQRMEQANKK
CEEARQEKEA MVMKYVRGEK ESLDLRKEKE TLEKKLRDAN KELEKNTNKI KQLSQEKGRL
HQLYETKEGE TTRLIREIDK LKEDINSHVI KVKWAQNKLK AEMDSHKETK DKLKETTTKL
TQAKEEADQI RKNCQDMIKT YQESEEIKSN ELDAKLRVTK GELEKQMQEK SDQLEMHHAK
IKELEDLKRT FKEGMDELRT LRTKVKCLED ERLRTEDELS KYKEIINRQK AEIQNLLDKV
KTADQLQEQL QRGKQEIENL KEEVESLNSL INDLQKDIEG SRKRESELLL FTERLTSKNA
QLQSESNSLQ SQFDKVSCSE SQLQSQCEQM KQTNINLESR LLKEEELRKE EVQTLQAELA
CRQTEVKALS TQVEELKDEL VTQRRKHASS IKDLTKQLQQ ARRKLDQVES GSYDKEVSSM
GSRSSSSGSL NARSSAEDRS PENTGSSVAV DNFPQVDKAM LIERIVRLQK AHARKNEKIE
FMEDHIKQLV EEIRKKTKII QSYILREESG TLSSEASDFN KVHLSRRGGI MASLYTSHPA
DNGLTLELSL EINRKLQAVL EDTLLKNITL KENLQTLGTE IERLIKHQHE LEQRTKKT
