ID   ZIC1_CHICK              Reviewed;         444 AA.
AC   Q8JJC0;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Zinc finger protein ZIC 1;
DE   AltName: Full=Zinc finger protein of the cerebellum 1;
GN   Name=ZIC1; Synonyms=ZIC;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE.
RX   PubMed=11944941; DOI=10.1006/dbio.2002.0598;
RA   Aruga J., Tohmonda T., Homma S., Mikoshiba K.;
RT   "Zic1 promotes the expansion of dorsal neural progenitors in spinal cord by
RT   inhibiting neuronal differentiation.";
RL   Dev. Biol. 244:329-341(2002).
CC   -!- FUNCTION: Acts as a transcriptional activator. Involved in
CC       neurogenesis. Plays important roles in the early stage of organogenesis
CC       of the CNS, as well as during dorsal spinal cord development and
CC       maturation of the cerebellum. Binds to the minimal GLI-consensus
CC       sequence 5'-TGGGTGGTC-3' (By similarity). {ECO:0000250,
CC       ECO:0000269|PubMed:11944941}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in dorsal undifferentiated neural cells
CC       in the spinal cord at stages 8 and 23 (at protein level). Expressed in
CC       the dorsal neural tube along almost the entire rostrocaudal extent and
CC       dorsomedial somites at stage 8. Expressed in the dorsal hindbrain,
CC       spinal cord, midbrain and forebrain at stage 17. Expressed in somites
CC       and the dorsal CNS at stage 23. {ECO:0000269|PubMed:11944941}.
CC   -!- SIMILARITY: Belongs to the GLI C2H2-type zinc-finger protein family.
CC       {ECO:0000305}.
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DR   EMBL; AB078610; BAB92091.1; -; mRNA.
DR   RefSeq; NP_989585.1; NM_204254.1.
DR   AlphaFoldDB; Q8JJC0; -.
DR   SMR; Q8JJC0; -.
DR   STRING; 9031.ENSGALP00000039679; -.
DR   PaxDb; Q8JJC0; -.
DR   GeneID; 374103; -.
DR   KEGG; gga:374103; -.
DR   CTD; 7545; -.
DR   VEuPathDB; HostDB:geneid_374103; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   InParanoid; Q8JJC0; -.
DR   OrthoDB; 768287at2759; -.
DR   PhylomeDB; Q8JJC0; -.
DR   PRO; PR:Q8JJC0; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0042472; P:inner ear morphogenesis; IEP:UniProtKB.
DR   GO; GO:0007389; P:pattern specification process; ISS:UniProtKB.
DR   GO; GO:0008589; P:regulation of smoothened signaling pathway; ISS:UniProtKB.
DR   GO; GO:0021510; P:spinal cord development; IMP:UniProtKB.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   InterPro; IPR041643; Znf_ZIC.
DR   Pfam; PF00096; zf-C2H2; 3.
DR   Pfam; PF18366; zf_ZIC; 1.
DR   SMART; SM00355; ZnF_C2H2; 5.
DR   SUPFAM; SSF57667; SSF57667; 2.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE   1: Evidence at protein level;
KW   Activator; Cytoplasm; Developmental protein; Differentiation; DNA-binding;
KW   Metal-binding; Neurogenesis; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..444
FT                   /note="Zinc finger protein ZIC 1"
FT                   /id="PRO_0000406214"
FT   ZN_FING         222..257
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         271..293
FT                   /note="C2H2-type 2; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         299..323
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         329..353
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         359..381
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          372..432
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        383..432
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   444 AA;  48165 MW;  D5091DF5796D7F5B CRC64;
     MLLDAGPQYP AIGVTTFGSS RHHSAADVTD REVGLGINPF ADGMGAFKLN PGGHELASAG
     QTAFTSQAPG YAAALGHHHH PPHVGSYSSA AFNSTRDFLF RNRGFGEAAA ASAQHSLFAS
     AAGGFGGPHG HGDAAGHILF PGLHEQAAGH ASPNVVNGQM RLGFSGDMYG RAEQYGQVTS
     PRSEHYASSQ LHGYGHMNMN MAAHHGAGAF FRYMRQPIKQ ELICKWIEPE QLANPKKSCN
     KTFSTMHELV THVTVEHVGG PEQSNHICFW EECPREGKPF KAKYKLVNHI RVHTGEKPFP
     CPFPGCGKVF ARSENLKIHK RTHTGEKPFK CEFEGCDRRF ANSSDRKKHM HVHTSDKPYL
     CKMCDKSYTH PSSLRKHMKV HESSSQGSQP SPAASSGYES STPPTIVSPS TENQTASSLS
     PSSSAGHHTA SHSTLTSNFN EWYV