ZIC2B_XENLA
ID ZIC2B_XENLA Reviewed; 497 AA.
AC Q9YIB7;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Zinc finger protein ZIC 2-B;
DE AltName: Full=Zic-related-2 {ECO:0000312|EMBL:BAA34264.1};
DE Short=ZIC-R2 {ECO:0000303|Ref.1};
DE AltName: Full=Zinc finger protein of the cerebellum 2-B;
GN Name=zic2-b; Synonyms=sox-D {ECO:0000312|EMBL:BAA34264.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1] {ECO:0000312|EMBL:BAA34264.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Neuroectoderm {ECO:0000312|EMBL:BAA34264.1}, and
RC Neurula {ECO:0000312|EMBL:BAA34264.1};
RA Mizuseki K., Yamazaki H., Sasai Y.;
RT "Xenopus Zic-related-2; an early positive regulator of neural
RT differentiation.";
RL Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000312|EMBL:BAA34264.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Tail bud {ECO:0000312|EMBL:AAH42229.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcriptional repressor that inhibits neurogenesis and
CC induces neural and neural crest differentiation. Regulates
CC anteroposterior patterning in early development by inhibiting
CC expression of the nodal genes through the inhibition of vegt. Required
CC for gastrulation movements and for proper anterior neural and axial
CC development. May also act as a transcriptional activator. May bind to
CC the minimal GLI-consensus sequence 5'-TGGGTGGTC-3' (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q91689}. Cytoplasm
CC {ECO:0000250}.
CC -!- DOMAIN: The C2H2-type 3, 4 and 5 zinc finger domains are necessary for
CC transcription activation. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the GLI C2H2-type zinc-finger protein family.
CC {ECO:0000255}.
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DR EMBL; AB014461; BAA34264.1; -; mRNA.
DR EMBL; BC042229; AAH42229.1; -; mRNA.
DR RefSeq; NP_001079428.1; NM_001085959.1.
DR AlphaFoldDB; Q9YIB7; -.
DR SMR; Q9YIB7; -.
DR DNASU; 379115; -.
DR GeneID; 379115; -.
DR KEGG; xla:379115; -.
DR CTD; 379115; -.
DR Xenbase; XB-GENE-6251643; zic2.S.
DR OrthoDB; 768287at2759; -.
DR Proteomes; UP000186698; Chromosome 2S.
DR Bgee; 379115; Expressed in egg cell and 9 other tissues.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0031490; F:chromatin DNA binding; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0009952; P:anterior/posterior pattern specification; ISS:UniProtKB.
DR GO; GO:0042074; P:cell migration involved in gastrulation; ISS:UniProtKB.
DR GO; GO:0050768; P:negative regulation of neurogenesis; ISS:UniProtKB.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0014034; P:neural crest cell fate commitment; ISS:UniProtKB.
DR GO; GO:0014029; P:neural crest formation; ISS:UniProtKB.
DR GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; ISS:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0007601; P:visual perception; ISS:UniProtKB.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR041643; Znf_ZIC.
DR Pfam; PF00096; zf-C2H2; 3.
DR Pfam; PF18366; zf_ZIC; 1.
DR SMART; SM00355; ZnF_C2H2; 5.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 2: Evidence at transcript level;
KW Activator; Cytoplasm; Developmental protein; Differentiation; DNA-binding;
KW Gastrulation; Metal-binding; Neurogenesis; Nucleus; Reference proteome;
KW Repeat; Repressor; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..497
FT /note="Zinc finger protein ZIC 2-B"
FT /id="PRO_0000364027"
FT ZN_FING 273..308
FT /note="C2H2-type 1; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 317..344
FT /note="C2H2-type 2; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 350..374
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 380..404
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 410..432
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 58..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 143..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 423..473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 435..473
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 497 AA; 53489 MW; 521BFAB15F8A433E CRC64;
MLLDAGPQFP ALGVGTFARH HHHHHHHHAA VAAAAAAAAE MQERELSLAQ NSFVEPTHMG
AFKMNPGGGS GGGSGGGGGA GPNGGAGASG PHDLSPPGQT SAFTSQAGYP ASALAPHSAY
TGAAAFNSPR DFLFRGRGFA EGSAAAGGGQ HGLFGPPAGS LHHHPHHHHQ LSHGEHPQGH
LLFPGIHDQH AAASQNTLGG QMRLGLPGEV FGRTDQYRQV SSPRGDPYTA AQLHNQYSPM
NMGMNMAAHH HHHHHHPGAF FRYMRQQCIK QELICKWIDP EQLNNPKKSC NKTFSTMHEL
VTHMSVEHVG GPEQSNHICF WEECAREGKP FKAKYKLVNH IRVHTGEKPF PCPFPGCGKV
FARSENLKIH KRTHTGEKPF QCEFEGCDRR FANSSDRKKH MHVHTSDKPY LCKMCDKSYT
HPSSLRKHMK VHESSPQGSE SSPAASSGYE SSTPPGLVSP NSETQNPNLS PAAVSAVHSV
SSGASGTLAS NFNEWYV
