CC186_MOUSE
ID CC186_MOUSE Reviewed; 917 AA.
AC Q8C9S4; Q6P3D6; Q8CJC0;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 2.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Coiled-coil domain-containing protein 186;
DE AltName: Full=Oocyte-testis gene 1 protein;
GN Name=Ccdc186; Synonyms=Otg1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Varani S., Racie L., Matzuk M.M.;
RT "Expression and genomic characterization of Otg1, a novel gene expressed in
RT postnatal germ cells in the mouse.";
RL Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-362.
RC STRAIN=C57BL/6J; TISSUE=Thymus;
RA Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P.,
RA Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K.,
RA Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K.,
RA Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y.,
RA Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T.,
RA Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R.,
RA Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K.,
RA Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T.,
RA Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S.,
RA Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M.,
RA Hayashizaki Y.;
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-234.
RC STRAIN=Czech II; TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-759, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Heart, Liver, Lung, Pancreas, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- TISSUE SPECIFICITY: Expressed in postnatal germ cells.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-19 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH64039.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
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DR EMBL; AF349751; AAN61566.1; -; mRNA.
DR EMBL; AK041398; BAC30931.1; -; mRNA.
DR EMBL; BC064039; AAH64039.1; ALT_SEQ; mRNA.
DR CCDS; CCDS29921.1; -.
DR RefSeq; NP_739563.1; NM_170757.1.
DR RefSeq; XP_006526914.1; XM_006526851.3.
DR AlphaFoldDB; Q8C9S4; -.
DR SMR; Q8C9S4; -.
DR STRING; 10090.ENSMUSP00000113457; -.
DR iPTMnet; Q8C9S4; -.
DR PhosphoSitePlus; Q8C9S4; -.
DR EPD; Q8C9S4; -.
DR MaxQB; Q8C9S4; -.
DR PaxDb; Q8C9S4; -.
DR PeptideAtlas; Q8C9S4; -.
DR PRIDE; Q8C9S4; -.
DR ProteomicsDB; 281489; -.
DR Antibodypedia; 2907; 29 antibodies from 10 providers.
DR DNASU; 213993; -.
DR Ensembl; ENSMUST00000076085; ENSMUSP00000075454; ENSMUSG00000035173.
DR Ensembl; ENSMUST00000118592; ENSMUSP00000113457; ENSMUSG00000035173.
DR GeneID; 213993; -.
DR KEGG; mmu:213993; -.
DR UCSC; uc008hzg.1; mouse.
DR CTD; 55088; -.
DR MGI; MGI:2445022; Ccdc186.
DR VEuPathDB; HostDB:ENSMUSG00000035173; -.
DR eggNOG; KOG0992; Eukaryota.
DR eggNOG; KOG1836; Eukaryota.
DR GeneTree; ENSGT00720000108851; -.
DR HOGENOM; CLU_007958_0_0_1; -.
DR InParanoid; Q8C9S4; -.
DR OMA; QEHTIKR; -.
DR OrthoDB; 604365at2759; -.
DR PhylomeDB; Q8C9S4; -.
DR TreeFam; TF328785; -.
DR BioGRID-ORCS; 213993; 0 hits in 72 CRISPR screens.
DR PRO; PR:Q8C9S4; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q8C9S4; protein.
DR Bgee; ENSMUSG00000035173; Expressed in animal zygote and 262 other tissues.
DR ExpressionAtlas; Q8C9S4; baseline and differential.
DR Genevisible; Q8C9S4; MM.
DR GO; GO:0005794; C:Golgi apparatus; IDA:MGI.
DR GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR GO; GO:0031267; F:small GTPase binding; IBA:GO_Central.
DR GO; GO:0042593; P:glucose homeostasis; IMP:MGI.
DR GO; GO:0035773; P:insulin secretion involved in cellular response to glucose stimulus; IMP:MGI.
DR GO; GO:0009617; P:response to bacterium; IEP:MGI.
DR GO; GO:0099518; P:vesicle cytoskeletal trafficking; IMP:MGI.
DR InterPro; IPR038830; CCDC186.
DR PANTHER; PTHR18911; PTHR18911; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Phosphoprotein; Reference proteome.
FT CHAIN 1..917
FT /note="Coiled-coil domain-containing protein 186"
FT /id="PRO_0000089824"
FT REGION 1..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 97..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 701..769
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 220..736
FT /evidence="ECO:0000255"
FT COILED 778..822
FT /evidence="ECO:0000255"
FT COILED 874..913
FT /evidence="ECO:0000255"
FT COMPBIAS 15..34
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 701..732
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 733..769
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 759
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
SQ SEQUENCE 917 AA; 104901 MW; 3409DE3409A8E1D6 CRC64;
MKIRSRFEEM QSELVPVSMS ETEHIASISS DATTEKTSEL RDDSCISVSG DESSRLETGA
ELLSLDSDRI LCQTNEHCSQ IEVQESHIPD CGSGENSCAN TDTCPEDSGQ IDDFPGGDFT
EQVSKTKEPE QTVTQILAEL KSSAPAEAAN PKTASASLYD TDCTRKLISE MKTVSASDDL
LGEIESELLS AEFAEGHQVP NGLNKGEQAL ALFEKCVHSR YLQQELTVKQ LIKENKNHQE
LILNICSEKD SLREELRKRT ETEKQHMNTI KQLELRIEEL NKEIKASKDQ LVAQDVTAKN
AIQQIHKEMA QRMDQANKKC EEARQEKEAM VMKYVRGEKE ALDLRKEKET LERKLRDASK
ELEKNTNKIK QLSQEKGRLQ QLYESKEGET TRLIREIEKL KEEMNSQVIK VKWAQNKLKA
EMDSHKETKD KLKETTTKLT QAKEEAEQIR QNCQDMIKTY QESEEIKSNE LDAKLRVTKG
ELEKQMQEKS DQLEMHHAKI KELEDLKRTF KEGMDELRTL RTKAKCLEDE RLRTEDELSK
YREIINRQKS EIQNLLDKVK ITDQLHEQLQ SGKQEIEHLK EEMESLNSLI NDLQKDIEGS
RKRESELLLF TEKLTSKNAQ LQSESSALQS QVDNLSCTES QLQSQCQQMG QANRNLESKL
LKEEELRKEE VQTLQAELSA AQTEVKALST QVEELKDELV TQRRKHASNV KDLSKQLQQA
RRKLEQTENG NHDKDISSMG SRSSSSGSLN ARISAEDRSP ENTSSSVAVD NFPEVDKAML
IERIVRLQKA HARKNEKIEF MEDHIKQLVE EIRKKTKIIQ SYVLREESGT LSSEASDFNK
VHLSRRGGIM ASLYTSHPAD SGLTLELSLE INRKLQAVLE DTLLKNITLK ENLQTLGTEI
ERLIKHQHEL EQRTKKA
