ID   ZIC3_XENTR              Reviewed;         441 AA.
AC   Q6DJQ6;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Zinc finger protein ZIC 3 {ECO:0000250|UniProtKB:O57311};
DE   AltName: Full=Zinc finger protein of the cerebellum 3 {ECO:0000250|UniProtKB:O57311};
GN   Name=zic3;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:AAH75118.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula {ECO:0000312|EMBL:AAH75118.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probably acts as a transcriptional activator. May bind to the
CC       minimal GLI-consensus sequence 5'-GGGTGGTC-3'. Can determine the
CC       ectodermal cell fate and promote the earliest step of neural and neural
CC       crest development. Involved in establishing left-right asymmetry in the
CC       embryo (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O57311}. Cytoplasm
CC       {ECO:0000250}.
CC   -!- DOMAIN: The C2H2-type 3, 4 and 5 zinc finger domains are necessary for
CC       transcription activation. The zinc fingers and the N-terminus are
CC       independently important for establishing the L/R axis (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GLI C2H2-type zinc-finger protein family.
CC       {ECO:0000255}.
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DR   EMBL; BC075118; AAH75118.1; -; mRNA.
DR   RefSeq; NP_001005691.1; NM_001005691.1.
DR   AlphaFoldDB; Q6DJQ6; -.
DR   SMR; Q6DJQ6; -.
DR   STRING; 8364.ENSXETP00000052876; -.
DR   PaxDb; Q6DJQ6; -.
DR   DNASU; 448197; -.
DR   Ensembl; ENSXETT00000052876; ENSXETP00000052876; ENSXETG00000024458.
DR   GeneID; 448197; -.
DR   KEGG; xtr:448197; -.
DR   CTD; 7547; -.
DR   Xenbase; XB-GENE-480431; zic3.
DR   eggNOG; KOG1721; Eukaryota.
DR   HOGENOM; CLU_002678_37_1_1; -.
DR   InParanoid; Q6DJQ6; -.
DR   OMA; PRHHDIG; -.
DR   OrthoDB; 768287at2759; -.
DR   PhylomeDB; Q6DJQ6; -.
DR   TreeFam; TF351425; -.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000024458; Expressed in gastrula and 12 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:0007417; P:central nervous system development; IBA:GO_Central.
DR   GO; GO:0007368; P:determination of left/right symmetry; ISS:UniProtKB.
DR   GO; GO:0000578; P:embryonic axis specification; ISS:UniProtKB.
DR   GO; GO:0014034; P:neural crest cell fate commitment; ISS:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   InterPro; IPR041643; Znf_ZIC.
DR   Pfam; PF00096; zf-C2H2; 3.
DR   Pfam; PF18366; zf_ZIC; 1.
DR   SMART; SM00355; ZnF_C2H2; 5.
DR   SUPFAM; SSF57667; SSF57667; 2.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE   2: Evidence at transcript level;
KW   Activator; Cytoplasm; Developmental protein; Differentiation; DNA-binding;
KW   Metal-binding; Neurogenesis; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..441
FT                   /note="Zinc finger protein ZIC 3"
FT                   /id="PRO_0000364028"
FT   ZN_FING         222..257
FT                   /note="C2H2-type 1; atypical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         266..293
FT                   /note="C2H2-type 2; atypical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         299..323
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         329..353
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         359..381
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          375..441
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        384..433
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   441 AA;  48413 MW;  7BAFDE89B94F45B7 CRC64;
     MTMLLDGGPQ FPTLGVGGFG TARHHEMSNR DAGMGLNPFT EPSHAAAFKL SPASHDLSSS
     QSSAFTPQAS GYANSLGHHA GQVPSYGGAA FNSTRDFLFR NRNSGIADST SAGGQHGLFA
     SHGPPGIGEP PGHLIFPGLH EQSSSHTSSN GHVVNGQMHL GLRGDIFGRP DPYRAVPSPR
     TDHYAAAQFH NYNHMNMSMN VAAHHGPGAF FRYMRQPIKQ ELSCKWLEES PMNRPQKTCD
     RTFSSMHELV THMTMEHVGG PEQTNHICYW EECPRGGKSF KAKYKLVNHI RVHTGEKPFP
     CPFPGCGKIF ARSENLKIHK RTHTGEKPFK CEFEGCDRRF ANSSDRKKHM HVHTSDKPYI
     CKVCDKSYTH PSSLRKHMKV HESQGSDSSP AASSGYESAT PPAMVSANSE EPSKNSSATH
     QTNNSSHNTG LLPPNFNEWY V