ZIC4_MOUSE
ID ZIC4_MOUSE Reviewed; 341 AA.
AC Q61467; Q8BG91;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 2.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Zinc finger protein ZIC 4;
DE AltName: Full=Zinc finger protein of the cerebellum 4;
GN Name=Zic4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, AND TISSUE SPECIFICITY.
RC TISSUE=Cerebellum;
RX PubMed=8682319; DOI=10.1016/0378-1119(96)00111-4;
RA Aruga J., Yozu A., Hayashizaki Y., Okazaki Y., Chapman V.M., Mikoshiba K.;
RT "Identification and characterization of Zic4, a new member of the mouse Zic
RT gene family.";
RL Gene 172:291-294(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP FUNCTION, DNA-BINDING, AND SUBCELLULAR LOCATION.
RX PubMed=15465018; DOI=10.1016/j.bbrc.2004.09.052;
RA Ishiguro A., Inoue T., Mikoshiba K., Aruga J.;
RT "Molecular properties of Zic4 and Zic5 proteins: functional diversity
RT within Zic family.";
RL Biochem. Biophys. Res. Commun. 324:302-307(2004).
RN [4]
RP DEVELOPMENTAL STAGE.
RX PubMed=15895369; DOI=10.1002/dvdy.20417;
RA Gaston-Massuet C., Henderson D.J., Greene N.D., Copp A.J.;
RT "Zic4, a zinc-finger transcription factor, is expressed in the developing
RT mouse nervous system.";
RL Dev. Dyn. 233:1110-1115(2005).
CC -!- FUNCTION: Binds to DNA. {ECO:0000269|PubMed:15465018}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15465018}.
CC -!- TISSUE SPECIFICITY: Exclusively expressed in the cerebellum.
CC {ECO:0000269|PubMed:8682319}.
CC -!- DEVELOPMENTAL STAGE: First expressed in embryo at 9 dpc. Expressed in
CC the dorsal midline of the forebrain at 10.5 dpc at the boundary between
CC the diencephalon and telencephalon, the septum, and the lamina
CC terminalis. Expressed in the choroid plexus of the third ventricle, the
CC dorsal part of the spinal neural tube, the dorsal sclerotome and the
CC dorsomedial lip of the dermomyotome between 10.5 and 12.5 dpc.
CC Expressed in the midline of the forebrain and in the dorsal spinal
CC neural tube at 12.5 dpc. {ECO:0000269|PubMed:15895369,
CC ECO:0000269|PubMed:8682319}.
CC -!- SIMILARITY: Belongs to the GLI C2H2-type zinc-finger protein family.
CC {ECO:0000305}.
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DR EMBL; D78174; BAA11240.1; ALT_TERM; mRNA.
DR EMBL; AK028305; BAC25871.1; -; mRNA.
DR EMBL; AK035908; BAC29239.1; -; mRNA.
DR CCDS; CCDS90639.1; -.
DR PIR; JC4875; JC4875.
DR RefSeq; NP_033602.2; NM_009576.2.
DR RefSeq; XP_011241029.1; XM_011242727.2.
DR AlphaFoldDB; Q61467; -.
DR SMR; Q61467; -.
DR STRING; 10090.ENSMUSP00000134053; -.
DR iPTMnet; Q61467; -.
DR PhosphoSitePlus; Q61467; -.
DR MaxQB; Q61467; -.
DR PaxDb; Q61467; -.
DR PRIDE; Q61467; -.
DR ProteomicsDB; 275064; -.
DR Antibodypedia; 33535; 405 antibodies from 27 providers.
DR DNASU; 22774; -.
DR Ensembl; ENSMUST00000066384; ENSMUSP00000069568; ENSMUSG00000036972.
DR GeneID; 22774; -.
DR KEGG; mmu:22774; -.
DR UCSC; uc009rak.1; mouse.
DR CTD; 84107; -.
DR MGI; MGI:107201; Zic4.
DR VEuPathDB; HostDB:ENSMUSG00000036972; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000154200; -.
DR InParanoid; Q61467; -.
DR OrthoDB; 592023at2759; -.
DR PhylomeDB; Q61467; -.
DR BioGRID-ORCS; 22774; 0 hits in 72 CRISPR screens.
DR ChiTaRS; Zic4; mouse.
DR PRO; PR:Q61467; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q61467; protein.
DR Bgee; ENSMUSG00000036972; Expressed in embryonic brain and 91 other tissues.
DR ExpressionAtlas; Q61467; baseline and differential.
DR Genevisible; Q61467; MM.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IDA:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IDA:MGI.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0007417; P:central nervous system development; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR041643; Znf_ZIC.
DR Pfam; PF00096; zf-C2H2; 2.
DR Pfam; PF18366; zf_ZIC; 1.
DR SMART; SM00355; ZnF_C2H2; 5.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Zinc;
KW Zinc-finger.
FT CHAIN 1..341
FT /note="Zinc finger protein ZIC 4"
FT /id="PRO_0000047254"
FT ZN_FING 135..169
FT /note="C2H2-type 1; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 178..205
FT /note="C2H2-type 2; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 211..235
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 241..265
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 271..295
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 36..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 289..309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 341 AA; 37437 MW; B4BB10DE736230CF CRC64;
MRLGRVCPRG PGKVRSPRHR FSCTLFVSTT GSSCGHHGPQ LAASSNPSVL PGLHEQPPQA
SHSRPLNGLL RLGIPGDMYA RSEPFAPGPM ARSDTLATAT ALHGYGGMNL TMNLTAPHGP
GAFFRYMRQP IKQELICKWL GDDSPMSPRP CSKTFSTMHE LVTHVTVEHV GGPEQANHIC
FWEECPRQGK PFKAKYKLVN HIRVHTGEKP FPCPFPGCGK VFARSENLKI HKRTHTGEKP
FRCEFEGCER RFANSSDRKK HSHVHTSDKP YMCKVRGCDK CYTHPSSLRK HMKVHGRSPP
PSSGYDSAIT SALASPSLES GREPSVACSA AVVVRGTDVS E
