ZIC4_XENLA
ID ZIC4_XENLA Reviewed; 530 AA.
AC A0JC51;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 12-DEC-2006, sequence version 1.
DT 03-AUG-2022, entry version 63.
DE RecName: Full=Zinc finger protein ZIC 4 {ECO:0000303|PubMed:16871625};
DE Short=XlZic4 {ECO:0000303|PubMed:16871625};
DE AltName: Full=Zinc finger protein of the cerebellum 4 {ECO:0000250|UniProtKB:Q8N9L1};
GN Name=zic4;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1] {ECO:0000305, ECO:0000312|EMBL:BAF36750.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RC TISSUE=Neurula {ECO:0000269|PubMed:16871625};
RX PubMed=16871625; DOI=10.1002/dvdy.20906;
RA Fujimi T.J., Mikoshiba K., Aruga J.;
RT "Xenopus Zic4: conservation and diversification of expression profiles and
RT protein function among the Xenopus Zic family.";
RL Dev. Dyn. 235:3379-3386(2006).
CC -!- FUNCTION: May bind to DNA (By similarity). Induces neural and neural
CC crest differentiation. Does not induce anterior neural tissue.
CC {ECO:0000250, ECO:0000269|PubMed:16871625}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O73689}.
CC -!- TISSUE SPECIFICITY: At mid-gastrula stage (stage 11.5), weakly
CC expressed in the prospective neural fold. Expressed in the neural plate
CC border region at early neurula stage (stage 15) with strongest
CC expression in the prospective regions of the hyoid and branchial
CC crests. Expression in the dorsal central nervous system (CNS) continues
CC through late neurula stage and early tail bud stages with expression
CC strongest in the olfactory placode and expression levels increasing as
CC development progresses. Becomes expressed in somites.
CC {ECO:0000269|PubMed:16871625}.
CC -!- DEVELOPMENTAL STAGE: Expressed zygotically. First detected at mid-
CC gastrula stage. {ECO:0000269|PubMed:16871625}.
CC -!- SIMILARITY: Belongs to the GLI C2H2-type zinc-finger protein family.
CC {ECO:0000255}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB259564; BAF36750.1; -; mRNA.
DR RefSeq; NP_001121252.1; NM_001127780.1.
DR AlphaFoldDB; A0JC51; -.
DR SMR; A0JC51; -.
DR PRIDE; A0JC51; -.
DR GeneID; 100158334; -.
DR KEGG; xla:100158334; -.
DR CTD; 100158334; -.
DR Xenbase; XB-GENE-1033019; zic4.L.
DR OrthoDB; 592023at2759; -.
DR Proteomes; UP000186698; Chromosome 5L.
DR Bgee; 100158334; Expressed in brain and 6 other tissues.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0014029; P:neural crest formation; IMP:UniProtKB.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR041643; Znf_ZIC.
DR Pfam; PF00096; zf-C2H2; 2.
DR Pfam; PF18366; zf_ZIC; 1.
DR SMART; SM00355; ZnF_C2H2; 5.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; DNA-binding; Metal-binding;
KW Neurogenesis; Nucleus; Reference proteome; Repeat; Zinc; Zinc-finger.
FT CHAIN 1..530
FT /note="Zinc finger protein ZIC 4"
FT /id="PRO_0000364029"
FT ZN_FING 284..317
FT /note="C2H2-type 1; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 326..353
FT /note="C2H2-type 2; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 359..383
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 389..413
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 419..443
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 31..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 87..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 432..530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 95..113
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..138
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 449..506
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 515..530
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 530 AA; 58225 MW; A444BA4FB78D8040 CRC64;
MSVEALGNTG MEPPFTKRNP ALRLVDLAGA HHPHHHHHPP HLPQSVTGYP GYVAHSHSMA
HVHPGEFAAD SRLGPSAAFR TEHIGHPGAL KLSPAHNPHH RHHHHHHHHH HMAGHAEVAS
SQTGAFGPAQ SPAGSYSSLP HPAQAICAAG RDWLIGRDVT VPVMPGLTEQ HSPSHHGMFL
STTGSYHGHH TEAGSHPYFS GAPEQASHAT PGGQPLNGHI RLGLPGDMYT RSDHFSQPVT
RTDHFASPSL HNYCGMNLNM NITPHHHGPG AFFRYMRQAI KQELICKWIE EDQLPKKLCS
KTFSTMHELV THVTVEHVGG PEQSNHICFW EECPREGKPF KAKYKLVNHI RVHTGEKPFP
CPFPGCGKVF ARSENLKIHK RTHTGEKPFK CEFEGCDRRF ANSSDRKKHS HVHTSDKPYN
CKVRGCDKSY THPSSLRKHM KVHCKSPPPS SGYESSIPSL VSPSSDSGQD PGATSSQPEP
PTSSQGANLS EWYVCQQGSA ASGIPTPPGN TPSPEHRKPS YSNWQATNTF
