ZIC5_XENLA
ID ZIC5_XENLA Reviewed; 515 AA.
AC Q9IB89;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Zinc finger protein ZIC 5 {ECO:0000303|PubMed:11091076, ECO:0000312|EMBL:BAA95699.1};
DE Short=XZic5 {ECO:0000303|PubMed:11091076};
DE Short=XlZic5 {ECO:0000303|PubMed:16871625};
DE AltName: Full=Zinc finger protein of the cerebellum 5 {ECO:0000303|PubMed:11091076};
GN Name=zic5 {ECO:0000312|EMBL:BAA95699.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1] {ECO:0000305, ECO:0000312|EMBL:BAA95699.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL
RP STAGE, AND INDUCTION.
RC TISSUE=Neurula {ECO:0000269|PubMed:11091076};
RX PubMed=11091076; DOI=10.1016/s0925-4773(00)00480-9;
RA Nakata K., Koyabu Y., Aruga J., Mikoshiba K.;
RT "A novel member of the Xenopus Zic family, Zic5, mediates neural crest
RT development.";
RL Mech. Dev. 99:83-91(2000).
RN [2] {ECO:0000305}
RP INDUCTION, AND TISSUE SPECIFICITY.
RX PubMed=12490555; DOI=10.1242/dev.00238;
RA Aybar M.J., Nieto M.A., Mayor R.;
RT "Snail precedes slug in the genetic cascade required for the specification
RT and migration of the Xenopus neural crest.";
RL Development 130:483-494(2003).
RN [3] {ECO:0000305}
RP INDUCTION, AND TISSUE SPECIFICITY.
RX PubMed=12783784; DOI=10.1242/dev.00531;
RA Monsoro-Burq A.-H., Fletcher R.B., Harland R.M.;
RT "Neural crest induction by paraxial mesoderm in Xenopus embryos requires
RT FGF signals.";
RL Development 130:3111-3124(2003).
RN [4] {ECO:0000305}
RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=16871625; DOI=10.1002/dvdy.20906;
RA Fujimi T.J., Mikoshiba K., Aruga J.;
RT "Xenopus Zic4: conservation and diversification of expression profiles and
RT protein function among the Xenopus Zic family.";
RL Dev. Dyn. 235:3379-3386(2006).
CC -!- FUNCTION: May bind to DNA (By similarity). Essential for neural crest
CC development, converting cells from an epidermal fate to a neural crest
CC cell fate. Does not induce anterior neural tissue. {ECO:0000250,
CC ECO:0000269|PubMed:11091076}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: At blastula and early gastrula stage (stages 9-
CC 10.25), expressed weakly throughout the ectoderm. At the late gastrula
CC stage (stages 11.5-13), expression is restricted to the prospective
CC neural fold region and anterior neural plate border region. Expression
CC becomes enhanced in the prospective midbrain and hindbrain region at
CC the late gastrula stage. Expression in the neural plate border region
CC continues in the neurula stage with expression in the anterior region
CC more enhanced. Expression represents the neural plate edges and part of
CC the neural fold. In the tailbud stages expression is restricted to the
CC eyes, dorsal brain and the posterior part of the dorsal spinal cord. In
CC the brain, expression is higher in the mesencephalon and
CC rhombencephalon. {ECO:0000269|PubMed:11091076,
CC ECO:0000269|PubMed:12490555, ECO:0000269|PubMed:12783784,
CC ECO:0000269|PubMed:16871625}.
CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
CC Expression increases from stage 11 (late gastrula), when the neural
CC crest is induced, through to the neurula and tailbud stages.
CC {ECO:0000269|PubMed:11091076, ECO:0000269|PubMed:16871625}.
CC -!- INDUCTION: By FGF-signaling. By snai1/snail. By zic1, zic2, zic3 and
CC zic5. {ECO:0000269|PubMed:11091076, ECO:0000269|PubMed:12490555,
CC ECO:0000269|PubMed:12783784}.
CC -!- SIMILARITY: Belongs to the GLI C2H2-type zinc-finger protein family.
CC {ECO:0000255}.
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DR EMBL; AB034983; BAA95699.1; -; mRNA.
DR RefSeq; NP_001079126.1; NM_001085657.1.
DR AlphaFoldDB; Q9IB89; -.
DR SMR; Q9IB89; -.
DR GeneID; 373661; -.
DR KEGG; xla:373661; -.
DR CTD; 373661; -.
DR Xenbase; XB-GENE-865408; zic5.S.
DR OMA; DSFRHSD; -.
DR OrthoDB; 592023at2759; -.
DR Proteomes; UP000186698; Chromosome 2S.
DR Bgee; 373661; Expressed in internal ear and 3 other tissues.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0014029; P:neural crest formation; IMP:UniProtKB.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR041643; Znf_ZIC.
DR Pfam; PF00096; zf-C2H2; 2.
DR Pfam; PF18366; zf_ZIC; 1.
DR SMART; SM00355; ZnF_C2H2; 5.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; DNA-binding; Metal-binding;
KW Neurogenesis; Nucleus; Reference proteome; Repeat; Zinc; Zinc-finger.
FT CHAIN 1..515
FT /note="Zinc finger protein ZIC 5"
FT /id="PRO_0000363991"
FT ZN_FING 267..300
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 309..336
FT /note="C2H2-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 342..366
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 372..396
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 402..426
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 149..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 430..467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 489..515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 515 AA; 56446 MW; 8BD0BF3E1D8D9160 CRC64;
MFGKDGRGGK IRTVSVDGLD CALMEPPLSK RSQTLRLADL AATQAHPHHN MTGFPGLGSH
QSHSLPAHMH PGELGSDPGV ALTPFGPEHM AQATALKLSP SAHPEAQTAA AFASPATVSY
PVAHPHSGYS TSRDFILRRE LSTSAMLGEQ HPAAGSPHHH HHHHPHSMFI SSTGSYAHPE
GVGHPLFPAI HEQAAAGVHH PLNGQMRLGL AGELYGRPEA FRAEHYAASS LHHSYNSMNL
NVNIAAAHPA TAGAFLRYMR QPIKQELICK WIDQDQSSKK PCSKTFSTMH ELVNHVAVEH
VGGPEQSNHI CFWEECAREG KPFKAKYKLV NHIRVHTGEK PFPCPFPGCG KVFARSENLK
IHKRTHTGEK PFKCEFDGCD RKFANSSDRK KHSHVHTSDK PYYCKVRGCD KSYTHPSSLR
KHMKIHCKSP PGSPTNGSMG YPAVGTPLDD PLSPAQEQVR GRSSNLSPQV TNLNEWYVCQ
ATGATVNMHT ASSNADSSES EDDEETYRHS ERTIR
