ID   ZIG3_CAEEL              Reviewed;         251 AA.
AC   G5EEY6;
DT   02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   14-DEC-2011, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Zwei Ig domain protein zig-3 {ECO:0000303|PubMed:11809975};
DE   AltName: Full=2 Ig domain protein zig-3 {ECO:0000303|PubMed:11809975};
DE   Flags: Precursor;
GN   Name=zig-3 {ECO:0000312|WormBase:C14F5.2};
GN   ORFNames=C14F5.2 {ECO:0000312|WormBase:C14F5.2};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN   [1] {ECO:0000312|EMBL:AAL59608.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX   PubMed=11809975; DOI=10.1126/science.1066642;
RA   Aurelio O., Hall D., Hobert O.;
RT   "Immunoglobulin-domain proteins required for maintenance of ventral nerve
RT   cord organization.";
RL   Science 295:686-690(2002).
RN   [2] {ECO:0000312|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [3] {ECO:0000305}
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=19737747; DOI=10.1534/genetics.109.107441;
RA   Benard C., Tjoe N., Boulin T., Recio J., Hobert O.;
RT   "The small, secreted immunoglobulin protein ZIG-3 maintains axon position
RT   in Caenorhabditis elegans.";
RL   Genetics 183:917-927(2009).
RN   [4] {ECO:0000305}
RP   DISRUPTION PHENOTYPE.
RX   PubMed=22829780; DOI=10.1371/journal.pgen.1002819;
RA   Benard C.Y., Blanchette C., Recio J., Hobert O.;
RT   "The secreted immunoglobulin domain proteins ZIG-5 and ZIG-8 cooperate with
RT   L1CAM/SAX-7 to maintain nervous system integrity.";
RL   PLoS Genet. 8:E1002819-E1002819(2012).
CC   -!- FUNCTION: Required for maintaining axon position of PVQ and PVP neurons
CC       postembryonically in the ventral nerve cord (VNC) by preventing axons
CC       drifting into the opposite side of the VNC that could occur during body
CC       growth and movement. {ECO:0000269|PubMed:19737747}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000255}.
CC   -!- TISSUE SPECIFICITY: Expressed in PVT, AIM and ASI neurons, in vulva and
CC       weakly in body wall muscles. {ECO:0000269|PubMed:11809975}.
CC   -!- DEVELOPMENTAL STAGE: Expression begins at the late L1 larval stage.
CC       {ECO:0000269|PubMed:11809975}.
CC   -!- DISRUPTION PHENOTYPE: At the L1 larval stage, display defects in the
CC       positioning of the ventral nerve cord (VNC) axons characterized by
CC       axons of PVQ and PVP neurons, but not of RMEV, HSN and AVK neurons,
CC       drifting into the opposite VNC side (axon flip-over) (PubMed:19737747).
CC       These defects are not enhanced in a zig-4 (gk34) mutant background or
CC       in zig-4 (gk34) dig-1 (ky188), zig-4 (gk34) sax-7 (nj48) or zig-4
CC       (gk34) egl-15 (n484) mutant background (PubMed:19737747). In a zig-1,
CC       zig-2, zig-4 or zig-5 or zig-8 mutant background, cell body positioning
CC       of ASI and ASH head neurons is normal (PubMed:22829780).
CC       {ECO:0000269|PubMed:19737747, ECO:0000269|PubMed:22829780}.
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DR   EMBL; AF456250; AAL59608.1; -; mRNA.
DR   EMBL; BX284606; CCD63845.1; -; Genomic_DNA.
DR   PIR; T15495; T15495.
DR   RefSeq; NP_509336.1; NM_076935.5.
DR   AlphaFoldDB; G5EEY6; -.
DR   SMR; G5EEY6; -.
DR   STRING; 6239.C14F5.2; -.
DR   EPD; G5EEY6; -.
DR   PaxDb; G5EEY6; -.
DR   PeptideAtlas; G5EEY6; -.
DR   EnsemblMetazoa; C14F5.2.1; C14F5.2.1; WBGene00006980.
DR   GeneID; 192088; -.
DR   KEGG; cel:CELE_C14F5.2; -.
DR   CTD; 192088; -.
DR   WormBase; C14F5.2; CE01781; WBGene00006980; zig-3.
DR   eggNOG; KOG3510; Eukaryota.
DR   GeneTree; ENSGT00970000196086; -.
DR   HOGENOM; CLU_072416_1_0_1; -.
DR   InParanoid; G5EEY6; -.
DR   OMA; PPIHANI; -.
DR   OrthoDB; 1482790at2759; -.
DR   PhylomeDB; G5EEY6; -.
DR   PRO; PR:G5EEY6; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00006980; Expressed in larva and 3 other tissues.
DR   GO; GO:0030424; C:axon; IBA:GO_Central.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0098632; F:cell-cell adhesion mediator activity; IBA:GO_Central.
DR   GO; GO:0007411; P:axon guidance; IBA:GO_Central.
DR   GO; GO:0070593; P:dendrite self-avoidance; IBA:GO_Central.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR043204; Basigin-like.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   PANTHER; PTHR10075; PTHR10075; 3.
DR   Pfam; PF07679; I-set; 1.
DR   SMART; SM00409; IG; 2.
DR   SMART; SM00408; IGc2; 2.
DR   SUPFAM; SSF48726; SSF48726; 2.
DR   PROSITE; PS50835; IG_LIKE; 2.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Immunoglobulin domain; Reference proteome; Repeat;
KW   Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..251
FT                   /note="Zwei Ig domain protein zig-3"
FT                   /id="PRO_5007661504"
FT   DOMAIN          42..144
FT                   /note="Ig-like C2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DOMAIN          160..244
FT                   /note="Ig-like C2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        65..128
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        181..228
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   251 AA;  27837 MW;  A609BBD3D394B07E CRC64;
     MLLICISVLA AISAHPLSSG EMRAAVSNLV REIDSTHLTT KPSLKIIEGL EDNTVSTGES
     VTLRCDVLST PTGVIYWEKD GQRIQGDKEL NVFEKVLNAM GPTVESGIIT SSYQIPCANL
     HHIGSYKCVA TNGHDTVESS AKISVEGQTV KCKSTRRSAP VITMSTESRF ELQDNAATLI
     CRADRRANWN WMFEDKKIDF DSGRYELLPS GDLLIRKIQW SDMGSYFCIA HNKYGESRGE
     TFLYPTKKHI A