ZIG4_CAEEL
ID ZIG4_CAEEL Reviewed; 253 AA.
AC G5ECB1;
DT 02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 14-DEC-2011, sequence version 1.
DT 03-AUG-2022, entry version 71.
DE RecName: Full=Zwei Ig domain protein zig-4 {ECO:0000303|PubMed:11809975};
DE AltName: Full=2 Ig domain protein zig-4 {ECO:0000303|PubMed:11809975};
DE Flags: Precursor;
GN Name=zig-4 {ECO:0000312|WormBase:C09C7.1};
GN ORFNames=C09C7.1 {ECO:0000312|WormBase:C09C7.1};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|EMBL:AAL59609.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL
RP STAGE, AND DISRUPTION PHENOTYPE.
RX PubMed=11809975; DOI=10.1126/science.1066642;
RA Aurelio O., Hall D., Hobert O.;
RT "Immunoglobulin-domain proteins required for maintenance of ventral nerve
RT cord organization.";
RL Science 295:686-690(2002).
RN [2] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3] {ECO:0000305}
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=19737747; DOI=10.1534/genetics.109.107441;
RA Benard C., Tjoe N., Boulin T., Recio J., Hobert O.;
RT "The small, secreted immunoglobulin protein ZIG-3 maintains axon position
RT in Caenorhabditis elegans.";
RL Genetics 183:917-927(2009).
RN [4] {ECO:0000305}
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=22829780; DOI=10.1371/journal.pgen.1002819;
RA Benard C.Y., Blanchette C., Recio J., Hobert O.;
RT "The secreted immunoglobulin domain proteins ZIG-5 and ZIG-8 cooperate with
RT L1CAM/SAX-7 to maintain nervous system integrity.";
RL PLoS Genet. 8:E1002819-E1002819(2012).
CC -!- FUNCTION: Required for maintaining axon position of PVQ and PVP neurons
CC postembryonically in the ventral nerve cord (VNC) by preventing axons
CC drifting into the opposite side of the VNC that could occur during body
CC growth and movement. {ECO:0000269|PubMed:11809975,
CC ECO:0000269|PubMed:19737747}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Expressed in PVT, ASK, BAG, M2 and ASI neurons. In
CC L1 larvae, expressed in pharyngeal ectoderm and mesoderm.
CC {ECO:0000269|PubMed:11809975}.
CC -!- DEVELOPMENTAL STAGE: Expression begins at the late L1 larval stage.
CC {ECO:0000269|PubMed:11809975}.
CC -!- DISRUPTION PHENOTYPE: At the L1 larval stage, display defects in the
CC positioning of the ventral nerve cord (VNC) axons characterized by
CC axons of embryonically generated PVQ and PVP neurons, but not of RMEV,
CC HSN and AVK neurons, from the left and right VNC drifting into the
CC opposite cord (axon flip-over) (PubMed:11809975, PubMed:19737747).
CC These defects are not enhanced in a zig-3 (tm924) mutant background or
CC in zig-3 (tm924) dig-1 (ky188), zig-3 (tm924) sax-7 (nj48) or zig-3
CC (tm924) egl-15 (n484) mutant background (PubMed:19737747). In a zig-1,
CC zig-2, zig-3 or zig-5 or zig-8 mutant background, cell body positioning
CC of ASI and ASH head neurons is normal (PubMed:22829780).
CC {ECO:0000269|PubMed:11809975, ECO:0000269|PubMed:19737747,
CC ECO:0000269|PubMed:22829780}.
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DR EMBL; AF456251; AAL59609.1; -; mRNA.
DR EMBL; BX284606; CCD63842.1; -; Genomic_DNA.
DR PIR; T15475; T15475.
DR RefSeq; NP_509335.1; NM_076934.5.
DR AlphaFoldDB; G5ECB1; -.
DR SMR; G5ECB1; -.
DR STRING; 6239.C09C7.1; -.
DR EPD; G5ECB1; -.
DR PaxDb; G5ECB1; -.
DR PeptideAtlas; G5ECB1; -.
DR EnsemblMetazoa; C09C7.1.1; C09C7.1.1; WBGene00006981.
DR GeneID; 181051; -.
DR KEGG; cel:CELE_C09C7.1; -.
DR CTD; 181051; -.
DR WormBase; C09C7.1; CE02468; WBGene00006981; zig-4.
DR eggNOG; KOG3510; Eukaryota.
DR GeneTree; ENSGT00970000196086; -.
DR HOGENOM; CLU_072416_1_0_1; -.
DR InParanoid; G5ECB1; -.
DR OMA; QETFLYP; -.
DR OrthoDB; 1482790at2759; -.
DR PhylomeDB; G5ECB1; -.
DR PRO; PR:G5ECB1; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00006981; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0007411; P:axon guidance; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR GO; GO:0048666; P:neuron development; IMP:WormBase.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR043204; Basigin-like.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR10075; PTHR10075; 2.
DR Pfam; PF07679; I-set; 1.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 2.
DR SUPFAM; SSF48726; SSF48726; 2.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 2: Evidence at transcript level;
KW Disulfide bond; Immunoglobulin domain; Reference proteome; Repeat;
KW Secreted; Signal.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT CHAIN 17..253
FT /note="Zwei Ig domain protein zig-4"
FT /id="PRO_5007661405"
FT DOMAIN 43..146
FT /note="Ig-like C2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 162..245
FT /note="Ig-like C2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 67..130
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 183..229
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 253 AA; 27854 MW; 2AFE9058A75D53A4 CRC64;
MFAIALLSFL VVLINAHPPM HAEMHSAVVT LANEIDTNYL TSPAKIKIVA PLESALIPGG
ETYQLRCDIM STPAATIHWK FNGKLIQGSN ELNVEEKLLN FGKAIVDTGI VASILTIQCP
SAENSGTYSC VGYNGHQTIE TVAEVEIEGE ASGCRSNHKS APEIVFWTDS RFEMTGNVAT
LVCRANQQVD WVWMSNDELV KNNDKFTVLS NGDLVIKNIV WDDMGTYTCI ARNQFGEARQ
ETFLYPTAKK SSF
