CC187_HUMAN
ID CC187_HUMAN Reviewed; 1063 AA.
AC A0A096LP49; Q8N5P7;
DT 17-FEB-2016, integrated into UniProtKB/Swiss-Prot.
DT 26-NOV-2014, sequence version 1.
DT 03-AUG-2022, entry version 44.
DE RecName: Full=Coiled-coil domain-containing protein 187 {ECO:0000305};
GN Name=CCDC187 {ECO:0000312|HGNC:HGNC:30942};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A0A096LP49-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A0A096LP49-2; Sequence=VSP_058066;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH31926.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; FP326719; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC031926; AAH31926.1; ALT_INIT; mRNA.
DR CCDS; CCDS78462.1; -. [A0A096LP49-2]
DR RefSeq; NP_001278445.1; NM_001291516.1. [A0A096LP49-2]
DR RefSeq; XP_011516985.1; XM_011518683.2. [A0A096LP49-1]
DR AlphaFoldDB; A0A096LP49; -.
DR SMR; A0A096LP49; -.
DR IntAct; A0A096LP49; 2.
DR iPTMnet; A0A096LP49; -.
DR PhosphoSitePlus; A0A096LP49; -.
DR BioMuta; CCDC187; -.
DR jPOST; A0A096LP49; -.
DR MassIVE; A0A096LP49; -.
DR PeptideAtlas; A0A096LP49; -.
DR Antibodypedia; 58147; 15 antibodies from 8 providers.
DR DNASU; 399693; -.
DR Ensembl; ENST00000569961.5; ENSP00000456543.1; ENSG00000260220.7. [A0A096LP49-2]
DR Ensembl; ENST00000624277.3; ENSP00000485393.1; ENSG00000260220.7. [A0A096LP49-1]
DR GeneID; 399693; -.
DR KEGG; hsa:399693; -.
DR UCSC; uc064xbe.1; human. [A0A096LP49-1]
DR CTD; 399693; -.
DR GeneCards; CCDC187; -.
DR HGNC; HGNC:30942; CCDC187.
DR HPA; ENSG00000260220; Tissue enhanced (fallopian tube, pituitary gland, testis).
DR neXtProt; NX_A0A096LP49; -.
DR OpenTargets; ENSG00000260220; -.
DR VEuPathDB; HostDB:ENSG00000260220; -.
DR GeneTree; ENSGT00530000065015; -.
DR OrthoDB; 806866at2759; -.
DR PathwayCommons; A0A096LP49; -.
DR Reactome; R-HSA-9013106; RHOC GTPase cycle.
DR SignaLink; A0A096LP49; -.
DR BioGRID-ORCS; 399693; 0 hits in 21 CRISPR screens.
DR GenomeRNAi; 399693; -.
DR Pharos; A0A096LP49; Tdark.
DR PRO; PR:A0A096LP49; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; A0A096LP49; protein.
DR Bgee; ENSG00000260220; Expressed in right uterine tube and 62 other tissues.
DR ExpressionAtlas; A0A096LP49; baseline and differential.
DR GO; GO:0005813; C:centrosome; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0034453; P:microtubule anchoring; IEA:InterPro.
DR InterPro; IPR028750; CEP350.
DR PANTHER; PTHR13958; PTHR13958; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..1063
FT /note="Coiled-coil domain-containing protein 187"
FT /id="PRO_0000435396"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 62..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 219..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 300..319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 392..484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 496..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 551..658
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1010..1030
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 816..851
FT /evidence="ECO:0000255"
FT COMPBIAS 107..121
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 164..184
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 241..278
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 304..319
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 417..431
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 446..473
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 503..518
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 639..658
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..98
FT /note="Missing (in isoform 2)"
FT /id="VSP_058066"
FT CONFLICT 190
FT /note="M -> T (in Ref. 2; AAH31926)"
FT /evidence="ECO:0000305"
FT CONFLICT 347
FT /note="Y -> H (in Ref. 2; AAH31926)"
FT /evidence="ECO:0000305"
FT CONFLICT 413
FT /note="C -> R (in Ref. 2; AAH31926)"
FT /evidence="ECO:0000305"
FT CONFLICT 851
FT /note="L -> P (in Ref. 2; AAH31926)"
FT /evidence="ECO:0000305"
FT CONFLICT 917
FT /note="D -> E (in Ref. 2; AAH31926)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1063 AA; 114856 MW; 0E9464F37B352991 CRC64;
MPTLVVGTPP TCLGDTPQPC HKNSQRQGPF SHGAPGRAAD WKAVAKPRLC APAAEDDVAA
LRWPGPSQQP DPPWAAPHVV GSDDLKEPGP WGKACSLPMW STGPEARDGD SSVSSGRLSC
SSGGHDVCVS WKERPPQVLG PQQRPRKSDA RLEQLRDKIR AQAWQQGSCA SLGTSAPSSA
SRLHKASTLM LRRKGQEAKN PPPAPECSGF SILSAAERRV EAKASHGQGR ELSRVSQHQV
PVLREKPKRV KSSSCKREKT PKLPSPRRAA KDKHKDEDSE LVGVYAWRKG QALVRSLLGP
PPVLRRHHSK DPSRDPALTV DLGDSEKVIA AKCSPVCAQL PDATSAYSDQ QVSGNTPSLA
SFDQPATIQT AMAILQDLRQ QIQAGLELAQ ARKGGQELGP SKRRLQDVAG RGCCRDPNAQ
SSFSKSPWAM TERKHSSLER ARSVHTWEPW SSSTARESCP QRAWGAQGQD RSFQRPESPH
ERLGHFSQRP WSALAGQACS PQRAWGAQRQ GPSSQRPGSP PEKRSPFPQQ PWSAVATQPC
PRRAWTACET WEDPGPRLRN PLERPSPPAQ RPWSSSGVQR AGPQGKGRGI GSPVSAAKHA
LPRPTGSFPQ NPLGKEKDTL RPCPRSRGLL GPSHSSESLR EFMRQKAQAR RRQALEEKAS
ALRTRELRSR RLQEVYRQQR EAVLGRAVPV VSRTTPGIVT FVPSSAQSGG LEASGSLESP
VLEWSKVTSG MVLGGQEAPG SFCLCLNRAW NHAETLDPPG MGGPQDGRDA PVLLSASPSL
GSLELQDLTT RYLPRGMCIY LDPKEAEHLG TSSSLHLRHK QAQLQALETT AKVLKQRVDS
LTAKLQGAEA LDTVRDPAVG LLRSCPHSLP AAPTLATPTL ATPACPGALG PNWGRGAPGE
WVSMQPQPLL PPTYFLDGET LSWGPSWEQQ QSVSPRAHCE SKPRGFPEEG HVDVKPDKRL
QRGVAPFQAL SPSAGSSYAG PATLHPIWGS LGLEETPSVG GADSVAPCTP RSCGKGDPAD
RPWAGWSGGR GIHREHLPLP STRAWPYGVE KSFSTWRAST PRY
