ZIM2_HUMAN
ID ZIM2_HUMAN Reviewed; 527 AA.
AC Q9NZV7; Q2M3K1;
DT 27-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 172.
DE RecName: Full=Zinc finger imprinted 2;
DE AltName: Full=Zinc finger protein 656;
GN Name=ZIM2; Synonyms=ZNF656;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10708526; DOI=10.1006/geno.1999.6112;
RA Kim J., Bergmann A., Stubbs L.;
RT "Exon sharing of a novel human zinc-finger gene, ZIM2, and paternally
RT expressed gene 3 (PEG3).";
RL Genomics 64:114-118(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q9NZV7; P29972: AQP1; NbExp=3; IntAct=EBI-11962760, EBI-745213;
CC Q9NZV7; O95429: BAG4; NbExp=3; IntAct=EBI-11962760, EBI-2949658;
CC Q9NZV7; Q9H2G9: BLZF1; NbExp=3; IntAct=EBI-11962760, EBI-2548012;
CC Q9NZV7; Q8NEC5: CATSPER1; NbExp=5; IntAct=EBI-11962760, EBI-744545;
CC Q9NZV7; Q96HB5: CCDC120; NbExp=3; IntAct=EBI-11962760, EBI-744556;
CC Q9NZV7; Q7L775: EPM2AIP1; NbExp=6; IntAct=EBI-11962760, EBI-6255981;
CC Q9NZV7; Q3B820: FAM161A; NbExp=3; IntAct=EBI-11962760, EBI-719941;
CC Q9NZV7; Q8IVS8: GLYCTK; NbExp=3; IntAct=EBI-11962760, EBI-748515;
CC Q9NZV7; Q96IK5: GMCL1; NbExp=3; IntAct=EBI-11962760, EBI-2548508;
CC Q9NZV7; P49639: HOXA1; NbExp=3; IntAct=EBI-11962760, EBI-740785;
CC Q9NZV7; Q14005-2: IL16; NbExp=3; IntAct=EBI-11962760, EBI-17178971;
CC Q9NZV7; P60371: KRTAP10-6; NbExp=3; IntAct=EBI-11962760, EBI-12012928;
CC Q9NZV7; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-11962760, EBI-10172290;
CC Q9NZV7; P59991: KRTAP12-2; NbExp=3; IntAct=EBI-11962760, EBI-10176379;
CC Q9NZV7; Q9BYR9: KRTAP2-4; NbExp=3; IntAct=EBI-11962760, EBI-14065470;
CC Q9NZV7; Q9BYR7: KRTAP3-2; NbExp=3; IntAct=EBI-11962760, EBI-751260;
CC Q9NZV7; P48059-3: LIMS1; NbExp=3; IntAct=EBI-11962760, EBI-12864460;
CC Q9NZV7; Q99750: MDFI; NbExp=3; IntAct=EBI-11962760, EBI-724076;
CC Q9NZV7; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-11962760, EBI-10172526;
CC Q9NZV7; Q13064: MKRN3; NbExp=3; IntAct=EBI-11962760, EBI-2340269;
CC Q9NZV7; Q9HBE1-4: PATZ1; NbExp=3; IntAct=EBI-11962760, EBI-11022007;
CC Q9NZV7; O43189: PHF1; NbExp=3; IntAct=EBI-11962760, EBI-530034;
CC Q9NZV7; O15160: POLR1C; NbExp=5; IntAct=EBI-11962760, EBI-1055079;
CC Q9NZV7; P78424: POU6F2; NbExp=3; IntAct=EBI-11962760, EBI-12029004;
CC Q9NZV7; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-11962760, EBI-748391;
CC Q9NZV7; Q9BT92: TCHP; NbExp=3; IntAct=EBI-11962760, EBI-740781;
CC Q9NZV7; Q8WW24: TEKT4; NbExp=3; IntAct=EBI-11962760, EBI-750487;
CC Q9NZV7; Q63HR2: TNS2; NbExp=3; IntAct=EBI-11962760, EBI-949753;
CC Q9NZV7; Q5W5X9-3: TTC23; NbExp=3; IntAct=EBI-11962760, EBI-9090990;
CC Q9NZV7; O75604: USP2; NbExp=3; IntAct=EBI-11962760, EBI-743272;
CC Q9NZV7; Q8NA42: ZNF383; NbExp=3; IntAct=EBI-11962760, EBI-20110775;
CC Q9NZV7; Q96SQ5: ZNF587; NbExp=3; IntAct=EBI-11962760, EBI-6427977;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Highest levels of expression in adult testis;
CC modest levels in fetal kidney and brain.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AF166122; AAF61478.1; -; mRNA.
DR EMBL; BC104876; AAI04877.1; -; mRNA.
DR EMBL; BC104878; AAI04879.1; -; mRNA.
DR CCDS; CCDS33123.1; -.
DR RefSeq; NP_001139798.1; NM_001146326.1.
DR RefSeq; NP_001139799.1; NM_001146327.1.
DR RefSeq; NP_056178.3; NM_015363.4.
DR AlphaFoldDB; Q9NZV7; -.
DR SMR; Q9NZV7; -.
DR BioGRID; 117152; 56.
DR IntAct; Q9NZV7; 41.
DR MINT; Q9NZV7; -.
DR STRING; 9606.ENSP00000468984; -.
DR iPTMnet; Q9NZV7; -.
DR PhosphoSitePlus; Q9NZV7; -.
DR BioMuta; ZIM2; -.
DR DMDM; 20141058; -.
DR EPD; Q9NZV7; -.
DR MassIVE; Q9NZV7; -.
DR MaxQB; Q9NZV7; -.
DR PaxDb; Q9NZV7; -.
DR PeptideAtlas; Q9NZV7; -.
DR PRIDE; Q9NZV7; -.
DR Antibodypedia; 67536; 172 antibodies from 16 providers.
DR DNASU; 23619; -.
DR Ensembl; ENST00000593711.6; ENSP00000472306.1; ENSG00000269699.7.
DR Ensembl; ENST00000599935.5; ENSP00000468984.1; ENSG00000269699.7.
DR Ensembl; ENST00000601070.5; ENSP00000470326.1; ENSG00000269699.7.
DR GeneID; 23619; -.
DR KEGG; hsa:23619; -.
DR UCSC; uc002qnr.4; human.
DR CTD; 23619; -.
DR DisGeNET; 23619; -.
DR GeneCards; ZIM2; -.
DR HGNC; HGNC:12875; ZIM2.
DR HPA; ENSG00000269699; Tissue enhanced (ovary, testis).
DR neXtProt; NX_Q9NZV7; -.
DR OpenTargets; ENSG00000269699; -.
DR PharmGKB; PA37464; -.
DR VEuPathDB; HostDB:ENSG00000269699; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163493; -.
DR HOGENOM; CLU_525756_0_0_1; -.
DR InParanoid; Q9NZV7; -.
DR OMA; TVASNHC; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q9NZV7; -.
DR PathwayCommons; Q9NZV7; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q9NZV7; -.
DR BioGRID-ORCS; 23619; 5 hits in 1026 CRISPR screens.
DR ChiTaRS; ZIM2; human.
DR GenomeRNAi; 23619; -.
DR Pharos; Q9NZV7; Tbio.
DR PRO; PR:Q9NZV7; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q9NZV7; protein.
DR Bgee; ENSG00000269699; Expressed in oocyte and 126 other tissues.
DR ExpressionAtlas; Q9NZV7; baseline and differential.
DR Genevisible; Q9NZV7; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; NAS:UniProtKB.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; NAS:UniProtKB.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 2.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 5.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 3.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..527
FT /note="Zinc finger imprinted 2"
FT /id="PRO_0000047774"
FT DOMAIN 176..246
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 328..350
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 356..378
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 412..434
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 466..488
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 494..516
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 247..322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..27
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..64
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..96
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 263..279
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 110
FT /note="A -> T (in dbSNP:rs2191432)"
FT /id="VAR_021896"
FT VARIANT 408
FT /note="Q -> R (in dbSNP:rs8112407)"
FT /id="VAR_052931"
FT VARIANT 473
FT /note="R -> K (in dbSNP:rs10422475)"
FT /id="VAR_052932"
SQ SEQUENCE 527 AA; 61164 MW; 6FC2ED68C50B0DCF CRC64;
MYQPEDDNNS DVTSDDDMTR NRRESSPPHS VHSFSGDRDW DRRGRSRDME PRDRWSHTRN
PRSRMPPRDL SLPVVAKTSF EMDREDDRDS RAYESRSQDA ESYQNVVDLA EDRKPHNTIQ
DNMENYRKLL SLGFLAQDSV PAEKRNTEML DNLPSAGSQF PDFKHLGTFL VFEELVTFED
VLVDFSPEEL SSLSAAQRNL YREVMLENYR NLVSLGHQFS KPDIISRLEE EESYAMETDS
RHTVICQGES HDDPLEPHQG NQEKLLTPIT MNDPKTLTPE RSYGSDEFER SSNLSKQSKD
PLGKDPQEGT APGICTSPQS ASQENKHNRC EFCKRTFSTQ VALRRHERIH TGKKPYECKQ
CAEAFYLMPH LNRHQKTHSG RKTSGCNEGR KPSVQCANLC ERVRIHSQED YFECFQCGKA
FLQNVHLLQH LKAHEAARVL PPGLSHSKTY LIRYQRKHDY VGERACQCCD CGRVFSRNSY
LIQHYRTHTQ ERPYQCQLCG KCFGRPSYLT QHYQLHSQEK TVECDHC
