ZIM3_HUMAN
ID ZIM3_HUMAN Reviewed; 472 AA.
AC Q96PE6; Q14CA6;
DT 27-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 171.
DE RecName: Full=Zinc finger imprinted 3;
DE AltName: Full=Zinc finger protein 657;
GN Name=ZIM3; Synonyms=ZNF657;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11543637; DOI=10.1006/geno.2001.6621;
RA Kim J., Bergmann A., Wehri E., Lu X., Stubbs L.;
RT "Imprinting and evolution of two Kruppel-type zinc-finger genes, ZIM3 and
RT ZNF264, located in the PEG3/USP29 imprinted domain.";
RL Genomics 77:91-98(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q96PE6; Q8TAP4-4: LMO3; NbExp=3; IntAct=EBI-18199075, EBI-11742507;
CC Q96PE6; Q06587: RING1; NbExp=3; IntAct=EBI-18199075, EBI-752313;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AF365931; AAL11635.1; -; mRNA.
DR EMBL; BC114446; AAI14447.1; -; mRNA.
DR EMBL; BC114503; AAI14504.1; -; mRNA.
DR CCDS; CCDS33125.1; -.
DR RefSeq; NP_443114.1; NM_052882.1.
DR AlphaFoldDB; Q96PE6; -.
DR SMR; Q96PE6; -.
DR BioGRID; 125268; 4.
DR IntAct; Q96PE6; 2.
DR STRING; 9606.ENSP00000269834; -.
DR iPTMnet; Q96PE6; -.
DR PhosphoSitePlus; Q96PE6; -.
DR BioMuta; ZIM3; -.
DR DMDM; 20141013; -.
DR EPD; Q96PE6; -.
DR jPOST; Q96PE6; -.
DR MassIVE; Q96PE6; -.
DR PaxDb; Q96PE6; -.
DR PeptideAtlas; Q96PE6; -.
DR PRIDE; Q96PE6; -.
DR ProteomicsDB; 77684; -.
DR Antibodypedia; 33234; 39 antibodies from 17 providers.
DR DNASU; 114026; -.
DR Ensembl; ENST00000269834.1; ENSP00000269834.1; ENSG00000141946.1.
DR GeneID; 114026; -.
DR KEGG; hsa:114026; -.
DR MANE-Select; ENST00000269834.1; ENSP00000269834.1; NM_052882.1; NP_443114.1.
DR UCSC; uc002qnz.1; human.
DR CTD; 114026; -.
DR GeneCards; ZIM3; -.
DR HGNC; HGNC:16366; ZIM3.
DR HPA; ENSG00000141946; Not detected.
DR neXtProt; NX_Q96PE6; -.
DR OpenTargets; ENSG00000141946; -.
DR PharmGKB; PA38127; -.
DR VEuPathDB; HostDB:ENSG00000141946; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000164284; -.
DR HOGENOM; CLU_002678_0_12_1; -.
DR InParanoid; Q96PE6; -.
DR OMA; FSWKSSC; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q96PE6; -.
DR TreeFam; TF337055; -.
DR PathwayCommons; Q96PE6; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR BioGRID-ORCS; 114026; 8 hits in 1086 CRISPR screens.
DR GenomeRNAi; 114026; -.
DR Pharos; Q96PE6; Tdark.
DR PRO; PR:Q96PE6; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q96PE6; protein.
DR Bgee; ENSG00000141946; Expressed in testis and 2 other tissues.
DR Genevisible; Q96PE6; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 8.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 11.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 6.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..472
FT /note="Zinc finger imprinted 3"
FT /id="PRO_0000047775"
FT DOMAIN 8..80
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 167..189
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 195..217
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 223..245
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 251..273
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 279..301
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 307..329
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 335..357
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 363..385
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 391..413
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 419..441
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 447..470
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VARIANT 7
FT /note="R -> K (in dbSNP:rs10407445)"
FT /id="VAR_024222"
FT VARIANT 28
FT /note="E -> K (in dbSNP:rs2370134)"
FT /id="VAR_024223"
FT VARIANT 69
FT /note="L -> M (in dbSNP:rs4801200)"
FT /id="VAR_033599"
FT VARIANT 157
FT /note="N -> D (in dbSNP:rs7252632)"
FT /id="VAR_024224"
FT VARIANT 205
FT /note="G -> R (in dbSNP:rs35202951)"
FT /id="VAR_052933"
FT VARIANT 379
FT /note="I -> V (in dbSNP:rs4801433)"
FT /id="VAR_024225"
SQ SEQUENCE 472 AA; 54498 MW; 755279B78653F286 CRC64;
MNNSQGRVTF EDVTVNFTQG EWQRLNPEQR NLYRDVMLEN YSNLVSVGQG ETTKPDVILR
LEQGKEPWLE EEEVLGSGRA EKNGDIGGQI WKPKDVKESL AREVPSINKE TLTTQKGVEC
DGSKKILPLG IDDVSSLQHY VQNNSHDDNG YRKLVGNNPS KFVGQQLKCN ACRKLFSSKS
RLQSHLRRHA CQKPFECHSC GRAFGEKWKL DKHQKTHAEE RPYKCENCGN AYKQKSNLFQ
HQKMHTKEKP YQCKTCGKAF SWKSSCINHE KIHNAKKSYQ CNECEKSFRQ NSTLIQHKKV
HTGQKPFQCT DCGKAFIYKS DLVKHQRIHT GEKPYKCSIC EKAFSQKSNV IDHEKIHTGK
RAYECDLCGN TFIQKKNLIQ HKKIHTGEKP YECNRCGKAF FQKSNLHSHQ KTHSGERTYR
CSECGKTFIR KLNLSLHKKT HTGQKPYGCS ECGKAFADRS YLVRHQKRIH SR
