CC187_MOUSE
ID CC187_MOUSE Reviewed; 958 AA.
AC Q8C5V8;
DT 17-FEB-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Coiled-coil domain-containing protein 187 {ECO:0000305};
GN Name=Ccdc187 {ECO:0000312|MGI:MGI:3045295};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
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DR EMBL; AL773595; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK077032; BAC36576.1; -; mRNA.
DR CCDS; CCDS50539.1; -.
DR RefSeq; NP_808509.1; NM_177841.3.
DR AlphaFoldDB; Q8C5V8; -.
DR SMR; Q8C5V8; -.
DR STRING; 10090.ENSMUSP00000054283; -.
DR iPTMnet; Q8C5V8; -.
DR PhosphoSitePlus; Q8C5V8; -.
DR MaxQB; Q8C5V8; -.
DR PaxDb; Q8C5V8; -.
DR PRIDE; Q8C5V8; -.
DR ProteomicsDB; 265587; -.
DR Antibodypedia; 58147; 15 antibodies from 8 providers.
DR Ensembl; ENSMUST00000057224; ENSMUSP00000054283; ENSMUSG00000048038.
DR GeneID; 329366; -.
DR KEGG; mmu:329366; -.
DR UCSC; uc008ium.1; mouse.
DR CTD; 399693; -.
DR MGI; MGI:3045295; Ccdc187.
DR VEuPathDB; HostDB:ENSMUSG00000048038; -.
DR eggNOG; KOG4568; Eukaryota.
DR GeneTree; ENSGT00530000065015; -.
DR HOGENOM; CLU_012638_0_0_1; -.
DR InParanoid; Q8C5V8; -.
DR OrthoDB; 806866at2759; -.
DR PhylomeDB; Q8C5V8; -.
DR TreeFam; TF338851; -.
DR Reactome; R-MMU-9013106; RHOC GTPase cycle.
DR BioGRID-ORCS; 329366; 4 hits in 40 CRISPR screens.
DR ChiTaRS; Ccdc187; mouse.
DR PRO; PR:Q8C5V8; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8C5V8; protein.
DR Bgee; ENSMUSG00000048038; Expressed in seminiferous tubule of testis and 49 other tissues.
DR ExpressionAtlas; Q8C5V8; baseline and differential.
DR GO; GO:0005813; C:centrosome; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0034453; P:microtubule anchoring; IEA:InterPro.
DR InterPro; IPR028750; CEP350.
DR PANTHER; PTHR13958; PTHR13958; 3.
PE 2: Evidence at transcript level;
KW Coiled coil; Reference proteome.
FT CHAIN 1..958
FT /note="Coiled-coil domain-containing protein 187"
FT /id="PRO_0000435397"
FT REGION 116..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 345..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 470..492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 510..602
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 916..958
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 718..743
FT /evidence="ECO:0000255"
FT COMPBIAS 116..133
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 370..403
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 423..437
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 470..487
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 515..544
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 958 AA; 104957 MW; D167BF1D7A893624 CRC64;
MTTPLMGVMP TSLRATLQNC SRGNQQEGLF SPKAMGRMAG QKDSTKPRDE VFHPHAAKDS
LLATTLRWPV LSQQLSPPQT VPYVAWSGNI KDPSPYMKGC SLPMWSPCLD TKDVDSSVSS
GRMSGSSGGH ESCTLSHGPW KERPPLILGP QRQPRKSDPR LEQLRDKIRA QAQWQASCAS
LGTSAPSSAS CLYKTSTMLW RKTPKVTNAL PVPAFPGSGV LRTAEHRGKD RASLSLRREL
SKVPQHHTSV PRTNFKKVKN ASCKREISKS SILRRTAKGR GSDRKAAAVK ASPAHTWLCK
PMSAHSDQQV SKHTPSLAFQ DQSATIHGAM ETLQDLRQQI QAGLELTRSP RVDRKLSLSK
PKPQNLVGKR DRGLQSTQDM QGSSKTAWTV TEGKNSSLHR AGNLHSQQHR KKALAEHESC
PRRTWTGQGQ DSSFPRPGST PEKPRFFSQR PWSALARQTY PQRTWDAQGQ DISVQKSGSS
LKKPSPFSQR PWSALAGRAY SACEDREVFE PSPWNSLSRP HSALQDPWSN SFVQRSSPSS
KGKSAVPPPS KVKPAWPEPS QDLLQSKPAK EQDTPCPRPR GSLGQQHSSE SLRDFMRQKA
QARRQQALEQ KALAAHTLEL RNQRLQEVYR KQREAVLGKD IPVVSQRRPG IVTFVPMQSG
GMEAPGSLGS PREQTWSKVT SGMVLGDQEA PDSFCLCLNK PWNRIETQDT GRPLEGYKQA
RLQALETMAE ALRQRVDILT TKLDKPTSPD TSGDLASDVL PLCPSTAPAT PTLVPPSYLR
TLMSKGGRES PRDLVDSQAE PLLLSTCFQD GEMLPWSPSW ELPNPNLGTH IESQPQGPVS
STPASVSQVI PHTQSCPAGS SSHGALSKEA IQGLEKKLQR EMATLQALGA CMKSSLGMPD
APDPTRGSLW QEEMPEVKKE GLVTPWTTRS CGKGEPADRP WAGWSGGQGG LPWASSTA
