ID   ZIP10_CAEEL             Reviewed;         165 AA.
AC   Q22835;
DT   18-JUL-2018, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Transcription factor zip-10 {ECO:0000305};
GN   Name=zip-10 {ECO:0000312|WormBase:T27F2.4};
GN   ORFNames=T27F2.4 {ECO:0000312|WormBase:T27F2.4};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN   [1] {ECO:0000312|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2] {ECO:0000305}
RP   INDUCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=27623524; DOI=10.18632/aging.101029;
RA   Kato M., Kashem M.A., Cheng C.;
RT   "An intestinal microRNA modulates the homeostatic adaptation to chronic
RT   oxidative stress in C. elegans.";
RL   Aging (Albany NY) 8:1979-2005(2016).
RN   [3] {ECO:0000305}
RP   FUNCTION, SUBCELLULAR LOCATION, INDUCTION, AND MUTAGENESIS OF
RP   161-GLN--ASN-163.
RX   PubMed=29664006; DOI=10.7554/elife.35037;
RA   Jiang W., Wei Y., Long Y., Owen A., Wang B., Wu X., Luo S., Dang Y.,
RA   Ma D.K.;
RT   "A genetic program mediates cold-warming response and promotes stress-
RT   induced phenoptosis in C. elegans.";
RL   Elife 7:0-0(2018).
CC   -!- FUNCTION: Transcription factor that regulates the expression of genes
CC       in response to changes in temperature. In particular, binds to the
CC       promoter region of genes such as asp-17 in response to severe cold to
CC       warm temperature transitions to promote gene expression. Promotes
CC       stress-induced death, particularly in older animals, following cold
CC       shock followed by warming and this may have evolved as a form of kin
CC       survival under thermal stress conditions, favoring the survival of
CC       younger animals. {ECO:0000269|PubMed:29664006}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:29664006}.
CC   -!- INDUCTION: Negatively regulated by the microRNA mir-60
CC       (PubMed:27623524, PubMed:29664006). Induced in response to thermal
CC       stress in conditions where severe cold temperatures are followed by
CC       warmer temperatures (PubMed:29664006). {ECO:0000269|PubMed:29664006,
CC       ECO:0000305|PubMed:27623524}.
CC   -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown reduces the lifespan
CC       extension phenotype of the mir-60 loss of function mutant.
CC       {ECO:0000269|PubMed:27623524}.
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DR   EMBL; BX284605; CAA98551.1; -; Genomic_DNA.
DR   PIR; T25378; T25378.
DR   RefSeq; NP_505951.1; NM_073550.6.
DR   AlphaFoldDB; Q22835; -.
DR   SMR; Q22835; -.
DR   IntAct; Q22835; 13.
DR   STRING; 6239.T27F2.4; -.
DR   PaxDb; Q22835; -.
DR   EnsemblMetazoa; T27F2.4.1; T27F2.4.1; WBGene00012101.
DR   GeneID; 179599; -.
DR   KEGG; cel:CELE_T27F2.4; -.
DR   UCSC; T27F2.4; c. elegans.
DR   CTD; 179599; -.
DR   WormBase; T27F2.4; CE06522; WBGene00012101; zip-10.
DR   eggNOG; ENOG502THIB; Eukaryota.
DR   HOGENOM; CLU_1612306_0_0_1; -.
DR   InParanoid; Q22835; -.
DR   OMA; YRAQMRQ; -.
DR   OrthoDB; 1571840at2759; -.
DR   SignaLink; Q22835; -.
DR   PRO; PR:Q22835; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00012101; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0001046; F:core promoter sequence-specific DNA binding; IDA:UniProtKB.
DR   GO; GO:0045087; P:innate immune response; HEP:WormBase.
DR   GO; GO:0010468; P:regulation of gene expression; IDA:UniProtKB.
PE   1: Evidence at protein level;
KW   Activator; Coiled coil; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..165
FT                   /note="Transcription factor zip-10"
FT                   /id="PRO_0000444633"
FT   REGION          53..99
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          104..150
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        53..73
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        81..95
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MUTAGEN         161..163
FT                   /note="QIN->VIA: Abolishes death promoting effect."
FT                   /evidence="ECO:0000269|PubMed:29664006"
SQ   SEQUENCE   165 AA;  18288 MW;  F00B8D154A6EDE60 CRC64;
     MTTMTNSLIS NSVSSVPESL FSSASIHRPV AINPAMLAQF SINLPVLPFE SSASLGTSTT
     SSSRCSSTES SAAPGKIRRG RPQQEIADGQ DAHSQKKRHR RLYARQYRAQ MRQKVENVKS
     LHDEKEQLEL EVKALRQAVS GLQQENAQKD FLISILQLNN QINHS