ZIP11_CAEEL
ID ZIP11_CAEEL Reviewed; 228 AA.
AC Q9N5A8;
DT 25-MAY-2022, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Transcription factor zip-11 {ECO:0000303|PubMed:34804026};
DE AltName: Full=BZIP transcription factor family zip-11 {ECO:0000312|WormBase:W08E12.1};
GN Name=zip-11 {ECO:0000312|WormBase:W08E12.1};
GN ORFNames=W08E12.1 {ECO:0000312|WormBase:W08E12.1};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, INTERACTION WITH CEBP-2, SUBCELLULAR LOCATION, DEVELOPMENTAL
RP STAGE, INDUCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=34804026; DOI=10.3389/fimmu.2021.744454;
RA Zheng Z., Aihemaiti Y., Liu J., Afridi M.I., Yang S., Zhang X., Xu Y.,
RA Chen C., Tu H.;
RT "The bZIP Transcription Factor ZIP-11 Is Required for the Innate Immune
RT Regulation in Caenorhabditis elegans.";
RL Front. Immunol. 12:744454-744454(2021).
CC -!- FUNCTION: Transcription factor (By similarity). Involved in modulating
CC innate immune response pathways, acting to promote resistance against
CC infection by Gram-negative bacterium P.aeruginosa strain PA14
CC (PubMed:34804026). May act as part of a feedback regulatory loop with
CC the pmk-1/p38 MAPK pathway (PubMed:34804026). May also function in
CC concert with CCAAT/enhancer-binding protein cebp-2 to mediate immune
CC responses, independently of the pmk-1/p38 MAPK pathway
CC (PubMed:34804026). {ECO:0000250|UniProtKB:P18848,
CC ECO:0000269|PubMed:34804026}.
CC -!- SUBUNIT: Interacts with CCAAT/enhancer-binding protein cebp-2.
CC {ECO:0000269|PubMed:34804026}.
CC -!- INTERACTION:
CC Q9N5A8; Q8IG69: cebp-2; NbExp=3; IntAct=EBI-6740132, EBI-2914231;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978,
CC ECO:0000269|PubMed:34804026}.
CC -!- DEVELOPMENTAL STAGE: Expressed in intestine, pharynx, and hypodermis at
CC larval stage L4. {ECO:0000269|PubMed:34804026}.
CC -!- INDUCTION: By exposure to the Gram-negative bacterium P.aeruginosa
CC strain PA14. {ECO:0000269|PubMed:34804026}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown targeted to the
CC intestine, but not to neurons, hypodermis, muscle or germline, reduced
CC the resistance to infection by the Gram-positive bacterium P.aeruginosa
CC strain PA14 (PubMed:34804026). Reduces expression of pmk-1 pathway
CC dependent genes, such as systemic stress signaling mediator sysm-1 and
CC infection response gene irg-4 (PubMed:34804026).
CC {ECO:0000269|PubMed:34804026}.
CC -!- SIMILARITY: Belongs to the bZIP family. {ECO:0000305}.
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DR EMBL; BX284604; CCD74009.1; -; Genomic_DNA.
DR RefSeq; NP_500318.1; NM_067917.4.
DR AlphaFoldDB; Q9N5A8; -.
DR SMR; Q9N5A8; -.
DR IntAct; Q9N5A8; 6.
DR STRING; 6239.W08E12.1; -.
DR PaxDb; Q9N5A8; -.
DR EnsemblMetazoa; W08E12.1.1; W08E12.1.1; WBGene00021082.
DR GeneID; 177099; -.
DR KEGG; cel:CELE_W08E12.1; -.
DR UCSC; W08E12.1; c. elegans.
DR CTD; 177099; -.
DR WormBase; W08E12.1; CE21280; WBGene00021082; zip-11.
DR eggNOG; KOG4571; Eukaryota.
DR HOGENOM; CLU_1241080_0_0_1; -.
DR InParanoid; Q9N5A8; -.
DR OMA; EIPHEQS; -.
DR OrthoDB; 1341694at2759; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00021082; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR000837; AP-1.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR046347; bZIP_sf.
DR PANTHER; PTHR23351; PTHR23351; 1.
DR Pfam; PF00170; bZIP_1; 1.
DR SMART; SM00338; BRLZ; 1.
DR SUPFAM; SSF57959; SSF57959; 1.
DR PROSITE; PS50217; BZIP; 1.
DR PROSITE; PS00036; BZIP_BASIC; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..228
FT /note="Transcription factor zip-11"
FT /id="PRO_0000455157"
FT DOMAIN 166..224
FT /note="bZIP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 166..202
FT /note="Basic motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 203..210
FT /note="Leucine-zipper"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
SQ SEQUENCE 228 AA; 26456 MW; 83DD2537D75EF51E CRC64;
MWPPNAENNH CNYSYHEHAE LNPHDHYHHH HYPHSSVHHT ECYQTLSCPS DLPVETSYYN
SVPPSYQDLG QTDLSPQFWC AEVDCVHERC STKEIPHEQS KIFEEISKEC DHIMNSAGDC
EKCQVEHENG AQEAIPINDL VDIVMQTVDN LKKEGSSNDE TKLLSRKRQQ NKVAAARYRD
KQKAKWQDLL DQLEAEEDRN QRLKLQAGHL EKEVAEMRQA FLAKLAKK
