CC188_HUMAN
ID CC188_HUMAN Reviewed; 402 AA.
AC H7C350;
DT 17-FEB-2016, integrated into UniProtKB/Swiss-Prot.
DT 26-NOV-2014, sequence version 2.
DT 03-AUG-2022, entry version 59.
DE RecName: Full=Coiled-coil domain-containing protein 188 {ECO:0000305};
GN Name=CCDC188 {ECO:0000312|HGNC:HGNC:51899};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC protein {ECO:0000255}.
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DR EMBL; AC006547; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005261297.1; XM_005261240.3.
DR AlphaFoldDB; H7C350; -.
DR SMR; H7C350; -.
DR STRING; 9606.ENSP00000409542; -.
DR PhosphoSitePlus; H7C350; -.
DR BioMuta; CCDC188; -.
DR EPD; H7C350; -.
DR MassIVE; H7C350; -.
DR PaxDb; H7C350; -.
DR PeptideAtlas; H7C350; -.
DR PRIDE; H7C350; -.
DR Antibodypedia; 77519; 4 antibodies from 4 providers.
DR Ensembl; ENST00000439765.4; ENSP00000409542.2; ENSG00000234409.7.
DR MANE-Select; ENST00000439765.4; ENSP00000409542.2; NM_001365892.2; NP_001352821.1.
DR UCSC; uc062bro.1; human.
DR GeneCards; CCDC188; -.
DR HGNC; HGNC:51899; CCDC188.
DR HPA; ENSG00000234409; Tissue enriched (testis).
DR neXtProt; NX_H7C350; -.
DR OpenTargets; ENSG00000234409; -.
DR VEuPathDB; HostDB:ENSG00000234409; -.
DR eggNOG; ENOG502TF5Y; Eukaryota.
DR GeneTree; ENSGT00940000153380; -.
DR HOGENOM; CLU_036049_0_0_1; -.
DR InParanoid; H7C350; -.
DR OMA; YVYVVNP; -.
DR OrthoDB; 753737at2759; -.
DR BioGRID-ORCS; 388849; 9 hits in 158 CRISPR screens.
DR GenomeRNAi; 388849; -.
DR Pharos; H7C350; Tdark.
DR PRO; PR:H7C350; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; H7C350; protein.
DR Bgee; ENSG00000234409; Expressed in left testis and 91 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR026617; SMCO2/5.
DR PANTHER; PTHR22422; PTHR22422; 1.
DR Pfam; PF14992; TMCO5; 1.
PE 3: Inferred from homology;
KW Coiled coil; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..402
FT /note="Coiled-coil domain-containing protein 188"
FT /id="PRO_0000435398"
FT TRANSMEM 347..363
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 50..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 108..131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 154..189
FT /evidence="ECO:0000255"
SQ SEQUENCE 402 AA; 43548 MW; DDDAFED30E7F7FAE CRC64;
MEGLKTLGPC GHPHPQCPPT PASSSHGGGL DQPCQGFVGW PCLGPISSAH SVQSQRPFPV
PGAGGSGPTV EGEAPGLFLS SQEQRARDTE GPRQGDLEAG LGWGWPLHPG SNQGAPRQGG
SIGSGTRPCP CPPLSREGGA LASPRVALSQ LQCGLLGSAE QSFLQLEQEN HSLKRQNQEL
REQLGALLGP GQQFLPLCPE HSSCTALAWP PDPAGTQPLG NRAPLQLLRR ELCQGQEAFV
QQSQNELQQI RLCFERKKMV ITEVWDNVAE MHMALNNQAT GLLNLKKDIR GVLDQMEDIQ
LEILRERAQC RTRARKEKQM ASMSKGRPKL GSSKGLAGQL WLLTLRLLLG ALLVWTAAYV
YVVNPTPFEG LVPPLLSRAT VWKLRALLDP FLRLKVDGFL PF
