ZIP1_YEAST
ID ZIP1_YEAST Reviewed; 875 AA.
AC P31111; D6VSR5;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 2.
DT 03-AUG-2022, entry version 168.
DE RecName: Full=Synaptonemal complex protein ZIP1;
GN Name=ZIP1; OrderedLocusNames=YDR285W; ORFNames=D9819.9;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=BR1824-3B;
RX PubMed=7916652; DOI=10.1016/0092-8674(93)90114-6;
RA Sym M., Engebrecht J.A., Roeder G.S.;
RT "ZIP1 is a synaptonemal complex protein required for meiotic chromosome
RT synapsis.";
RL Cell 72:365-378(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169867;
RA Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
RA Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
RA Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
RA Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
RA Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
RA Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
RA Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
RA Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L.,
RA Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H.,
RA Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M.,
RA Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M.,
RA Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A.,
RA Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G.,
RA Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E.,
RA Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S.,
RA Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D.,
RA Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V.,
RA Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E.,
RA Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M.,
RA Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D.,
RA Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X.,
RA Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A.,
RA Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
RA Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T.,
RA Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L.,
RA Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E.,
RA Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L.,
RA Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M.,
RA Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
RA Mewes H.-W., Zollner A., Zaccaria P.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
RL Nature 387:75-78(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-481, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18407956; DOI=10.1074/mcp.m700468-mcp200;
RA Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
RT "A multidimensional chromatography technology for in-depth phosphoproteome
RT analysis.";
RL Mol. Cell. Proteomics 7:1389-1396(2008).
CC -!- FUNCTION: Required for meiotic chromosome synapsis and cell cycle
CC progression. May act as a molecular zipper to bring homologous
CC chromosomes in close apposition. ZIP1 may encode the transverse
CC filaments of the synaptonemal complex.
CC -!- INTERACTION:
CC P31111; Q06032: CST9; NbExp=3; IntAct=EBI-29645, EBI-30044;
CC -!- SUBCELLULAR LOCATION: Nucleus. Chromosome. Note=Synapsed meiotic
CC chromosomes.
CC -!- MISCELLANEOUS: Present with 391 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
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DR EMBL; L06487; AAA35239.1; -; Genomic_DNA.
DR EMBL; U51031; AAB64474.1; -; Genomic_DNA.
DR EMBL; BK006938; DAA12125.1; -; Genomic_DNA.
DR PIR; S70115; S70115.
DR RefSeq; NP_010571.1; NM_001180593.1.
DR AlphaFoldDB; P31111; -.
DR SMR; P31111; -.
DR BioGRID; 32338; 97.
DR ComplexPortal; CPX-1387; Synaptonemal complex.
DR DIP; DIP-1240N; -.
DR IntAct; P31111; 4.
DR MINT; P31111; -.
DR STRING; 4932.YDR285W; -.
DR iPTMnet; P31111; -.
DR PaxDb; P31111; -.
DR PRIDE; P31111; -.
DR EnsemblFungi; YDR285W_mRNA; YDR285W; YDR285W.
DR GeneID; 851879; -.
DR KEGG; sce:YDR285W; -.
DR SGD; S000002693; ZIP1.
DR VEuPathDB; FungiDB:YDR285W; -.
DR eggNOG; ENOG502R6M6; Eukaryota.
DR HOGENOM; CLU_341332_0_0_1; -.
DR InParanoid; P31111; -.
DR OMA; NTQKICS; -.
DR BioCyc; YEAST:G3O-29849-MON; -.
DR PRO; PR:P31111; -.
DR Proteomes; UP000002311; Chromosome IV.
DR RNAct; P31111; protein.
DR GO; GO:0000775; C:chromosome, centromeric region; IDA:SGD.
DR GO; GO:0000794; C:condensed nuclear chromosome; IC:ComplexPortal.
DR GO; GO:0000795; C:synaptonemal complex; IDA:SGD.
DR GO; GO:0000802; C:transverse filament; IDA:SGD.
DR GO; GO:0032184; F:SUMO polymer binding; IPI:SGD.
DR GO; GO:0007129; P:homologous chromosome pairing at meiosis; IMP:SGD.
DR GO; GO:0035825; P:homologous recombination; IC:ComplexPortal.
DR GO; GO:0045128; P:negative regulation of reciprocal meiotic recombination; IMP:SGD.
DR GO; GO:0033235; P:positive regulation of protein sumoylation; IMP:SGD.
DR GO; GO:1990166; P:protein localization to site of double-strand break; IMP:SGD.
DR GO; GO:0007131; P:reciprocal meiotic recombination; IMP:SGD.
PE 1: Evidence at protein level;
KW Chromosome; Coiled coil; Meiosis; Nucleus; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..875
FT /note="Synaptonemal complex protein ZIP1"
FT /id="PRO_0000066584"
FT REGION 47..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 127..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 738..831
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 177..333
FT /evidence="ECO:0000255"
FT COILED 397..438
FT /evidence="ECO:0000255"
FT COILED 456..752
FT /evidence="ECO:0000255"
FT COMPBIAS 738..752
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 753..779
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 786..810
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 811..826
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 481
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18407956"
FT CONFLICT 55
FT /note="T -> A (in Ref. 1; AAA35239)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 875 AA; 100035 MW; 674F12625CD9DDFD CRC64;
MSNFFRDSSM GFKPRPNIFA KLRVRDVDSD SSANTVVENS SNCLDVGSSI EGDDTFKKPH
KTSTEQELIT SMSLSQRNHG YSDDMEIGSP KKTTSTDQYN RILKNDVAAI ENDTDEDFEI
TEVREVSEGV AKETKESHGD PNDSETTLKD SKMHEYTMTN GKAPLHTSIN NSSTSSNDVL
LEAFTNTQRI CSNLKQELQK QQQDNAKLKV RLQSYASNSD KINEKVGKYK SCLETLQERI
ATLTSHKNNQ ETKLKDLRQN HQLYQRRISG FKTSIENLNK TINDLGKNKK EADAELMKKG
KEIEYLKREL DDCSGQLSEE KIKNSSLIQE MGKNREEMIK SIENFFSEDK AHHLLQFNKF
EERVHDLFEK KLQKHFDVAK DTLNVGLRNT TVELSSNTET MLKQQYEDIK ENLEQKMSSS
KDEMAKTINE LSVTQKGLIM GVQEELLTSS GNIQTALVSE MNNTRQELLD DASQTAKNYA
SLENLVKAYK AEIVQSNEYE ERIKHLESER STLSSQKNQI ISSLGTKEAQ YEDLVKKLEA
KNIEISQISG KEQSLTEKNE NLSNELKKVQ DQLEKLNNLN ITTKSNYENK ISSQNEIVKA
LVSENDTLKQ RIQQLVEIKE NEQKDHTTKL EAFQKNNEQL QKLNVEVVQL KAHELELEEQ
NRHLKNCLEK KETGVEESLS DVKTLKQQVI VLKSEKQDIT AEKLELQDNL ESLEEVTKNL
QQKVQSQKRE LEQKIKELEE IKNHKRNEPS KKGTQNFTKP SDSPKKNATT SNLFPNNSAA
IHSPMKKCPK VDHISKSRIN SSKETSKFND EFDLSSSSND DLELTNPSPI QIKPVRGKIK
KGSNCMKPPI SSRKKLLLVE DEDQSLKISK KRRRK
