ID   ZIP2_CANGA              Reviewed;         676 AA.
AC   Q6FRL4;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Protein ZIP2;
DE   AltName: Full=Zipping up meiotic chromosomes protein 2;
GN   Name=ZIP2; OrderedLocusNames=CAGL0H07645g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Required for initiation of meiotic chromosome synapsis.
CC       Involved in synaptonemal complex formation, a structure that tethers a
CC       pair of homologous chromosomes along their lengths and plays a central
CC       role in recombination and homolog segregation during meiosis (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
CC       Note=localizes to a meiosis specific chromosomal structure called the
CC       synaptonemal complex (SC) formed during meiotic prophase.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ZIP2 family. {ECO:0000305}.
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DR   EMBL; CR380954; CAG60063.1; -; Genomic_DNA.
DR   RefSeq; XP_447130.1; XM_447130.1.
DR   AlphaFoldDB; Q6FRL4; -.
DR   SMR; Q6FRL4; -.
DR   STRING; 5478.XP_447130.1; -.
DR   PRIDE; Q6FRL4; -.
DR   EnsemblFungi; CAG60063; CAG60063; CAGL0H07645g.
DR   GeneID; 2888864; -.
DR   KEGG; cgr:CAGL0H07645g; -.
DR   CGD; CAL0131522; CAGL0H07645g.
DR   VEuPathDB; FungiDB:CAGL0H07645g; -.
DR   eggNOG; ENOG502S02Z; Eukaryota.
DR   HOGENOM; CLU_385036_0_0_1; -.
DR   InParanoid; Q6FRL4; -.
DR   OMA; NTSMIPH; -.
DR   Proteomes; UP000002428; Chromosome H.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Cell cycle; Chromosomal rearrangement; Chromosome; Chromosome partition;
KW   DNA-binding; Meiosis; Nucleotide-binding; Nucleus; Reference proteome.
FT   CHAIN           1..676
FT                   /note="Protein ZIP2"
FT                   /id="PRO_0000333498"
SQ   SEQUENCE   676 AA;  78731 MW;  A8343B6FA9161EDB CRC64;
     MCIPENMWTP PTLPLPLQSF PKENIPIDKR TQKCLLQIKK LCSTQFSLNK EYKSTFNLID
     YKLQRIIQPH NLSVNPINSF WPHTVERLVV PPIYYEMLSN QQIYTLDYLQ INPQYHIPIK
     SVQKSKQKAF QLNLLPLPRQ KFRQIQLESY MPSKLESKMT SICEESLPKT VIFDYHGYFD
     LKQKLLTSNT LLTARLNPIS TSAGCRQKLK FTTHWPSWTI EINTDISNIS RLHKVLFDEN
     FNKIELFKLA SCNLKVERST RIKKNHIATW KLDKLQLKEL DWDPLKKLKA YSVQKKINCD
     EVHAQATFII TPLKLVLMPI NSSEIHILQN NYGNIVISAK SFGNLQPKNT IESSQVSNNN
     TKLLKEARTT GSSMSDRSTS ITSYKCSSLV PEKRSLLDSN LISIVQLKKL RTSYPQSTES
     HSGEMSLLRL LHSNSCKTEI QQIDTWYDTA KLNTTPKTTS FKLEGQDIKK KVSIIANEYD
     ISTTYQITRL LRERQYSNIE EYRIKLPCHF ILSFSSCLLL VEISKVFQCI TAGELFLERT
     LSILIKHFRV VHVFIEYEPN TELYDKDIFW KAKLILNNPQ VRTIFIPKFS NNLTTWMLRV
     TTIQGQKFQE MVKDNTLSHF NINPYQEYLI QEKLRESSPS RLIETLVFGD HVLDGILTPI
     HINSLKIFAR ENWHLT