ID   ZIP2_KLULA              Reviewed;         675 AA.
AC   Q6CR69;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Protein ZIP2;
DE   AltName: Full=Zipping up meiotic chromosomes protein 2;
GN   Name=ZIP2; OrderedLocusNames=KLLA0D11418g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Required for initiation of meiotic chromosome synapsis.
CC       Involved in synaptonemal complex formation, a structure that tethers a
CC       pair of homologous chromosomes along their lengths and plays a central
CC       role in recombination and homolog segregation during meiosis (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
CC       Note=localizes to a meiosis specific chromosomal structure called the
CC       synaptonemal complex (SC) formed during meiotic prophase.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ZIP2 family. {ECO:0000305}.
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DR   EMBL; CR382124; CAH00666.1; -; Genomic_DNA.
DR   RefSeq; XP_453570.1; XM_453570.1.
DR   AlphaFoldDB; Q6CR69; -.
DR   SMR; Q6CR69; -.
DR   STRING; 28985.XP_453570.1; -.
DR   PRIDE; Q6CR69; -.
DR   EnsemblFungi; CAH00666; CAH00666; KLLA0_D11418g.
DR   GeneID; 2893561; -.
DR   KEGG; kla:KLLA0_D11418g; -.
DR   eggNOG; ENOG502S02Z; Eukaryota.
DR   HOGENOM; CLU_407123_0_0_1; -.
DR   InParanoid; Q6CR69; -.
DR   OMA; NTSMIPH; -.
DR   Proteomes; UP000000598; Chromosome D.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Cell cycle; Chromosomal rearrangement; Chromosome; Chromosome partition;
KW   DNA-binding; Meiosis; Nucleotide-binding; Nucleus; Reference proteome.
FT   CHAIN           1..675
FT                   /note="Protein ZIP2"
FT                   /id="PRO_0000333499"
SQ   SEQUENCE   675 AA;  78486 MW;  548D0C44E4106800 CRC64;
     MVSAMWDTSA LKLRNIFEEE FGGYLEKRLR ESIQLNRPTK RYLKLATRSD IDLKFHKVGK
     KESNGSSLVK YIIEFDTTAI LVKGYIRPWN NPEWKCKAPY NSNQNVDTRS LYKEKIIVRD
     NVKDLFSAAL TKLDLSVRLN KFDQNVHAKY RLNEDFLQPL GRTLRHSCEF PVMHSRLVQR
     ESELYEEFLS YDLPKRQMTT MDIQFKTVKV QSFQQYKIQY IQTLTREKTS QEYTSSARLP
     HWQSNQIQNS SIKFLKLCCE DEDFHPLELY KLENPKADQF QRKAVYRSKP IKPKWRISDE
     IIKRLNWNPF KELNLPKNSE LLESLRDVQV RCTSYALVFK RIPSSKIDLM VSKIPVSFRS
     VNAISYDQFD PKSKENVQES SQCIDSLANE ETTDVDEVTN KRIMTSGKRS FINADLVSII
     AAKRSKLKRL SISNGDVNPV ATLNETVEQS TMSNVTFQLS DKSFHNAEEK VIIFNAEYIA
     KNYKLINFLH QNNFCVLEMD LGDHSDILLD ASTCLILRNI TSVYQKQVDS FPLLRAIQEL
     KCKYKRVVIF LSYSERSLAL DSNLAYKTQL LLNCLGGTTT HLVEETQLKL TATWISLYCG
     TNTPNEQQIY RMSLSKEVLQ HFDINPIAIE SILSLTSLEE FLSISYGKRA LLYGKFLTEY
     QLAHIDDFVT MSWSE