ID   ZIP2_VANPO              Reviewed;         718 AA.
AC   A7TPF8;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 47.
DE   RecName: Full=Protein ZIP2;
DE   AltName: Full=Zipping up meiotic chromosomes protein 2;
GN   Name=ZIP2; ORFNames=Kpol_507p6;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC   Y-8283 / UCD 57-17;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- FUNCTION: Required for initiation of meiotic chromosome synapsis.
CC       Involved in synaptonemal complex formation, a structure that tethers a
CC       pair of homologous chromosomes along their lengths and plays a central
CC       role in recombination and homolog segregation during meiosis (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
CC       Note=Localizes to a meiosis specific chromosomal structure called the
CC       synaptonemal complex (SC) formed during meiotic prophase.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ZIP2 family. {ECO:0000305}.
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DR   EMBL; DS480442; EDO15844.1; -; Genomic_DNA.
DR   RefSeq; XP_001643702.1; XM_001643652.1.
DR   AlphaFoldDB; A7TPF8; -.
DR   SMR; A7TPF8; -.
DR   STRING; 436907.A7TPF8; -.
DR   EnsemblFungi; EDO15844; EDO15844; Kpol_507p6.
DR   GeneID; 5543955; -.
DR   KEGG; vpo:Kpol_507p6; -.
DR   eggNOG; ENOG502S02Z; Eukaryota.
DR   HOGENOM; CLU_385036_0_0_1; -.
DR   InParanoid; A7TPF8; -.
DR   OMA; NTSMIPH; -.
DR   OrthoDB; 1487809at2759; -.
DR   PhylomeDB; A7TPF8; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Cell cycle; Chromosomal rearrangement; Chromosome; Chromosome partition;
KW   DNA-binding; Meiosis; Nucleotide-binding; Nucleus; Reference proteome.
FT   CHAIN           1..718
FT                   /note="Protein ZIP2"
FT                   /id="PRO_0000333501"
SQ   SEQUENCE   718 AA;  84970 MW;  2FD82822363E3E40 CRC64;
     MTDFSNWSCE YHTTFDEIVR IENKFKEHLK VDKRTRRRLL ECCSKDFEIL KFKGLHGIPC
     YQIEKINVNI EIISLNGLNT NNNGRLTEKW NPDRIGNFDF ASYNKREKLL IDKETKVLLS
     WISGLKLENE DIMEFPNPLI KINSEFNSYI IETCNFCYLT KELLVYSPKS SLDELMPNDL
     NKNFEKLENE KIIQCELNFN QHYSSEILPF LEFKPYRTIL FLNNFLIEVN MNGISSQNIP
     EKTKREFINW NYENQSEINT SWDINLWSKV FDEDYNEIEF LKLKTPNEII TEDVIENFKS
     YNSKRFKVYW KLDKNETKKL EWNPIKSYIS KNLTTKILLN EKLTKQNEYT IKKPELNFKK
     ILYNIIDLID IENGTFGSLN LVLNNKIENS FQDPLTKNDE SSSINVEKEI SESTLQINTS
     MIPHKRSYID EELKSILEIK RKKKNLNDRN LKDSEDKTGS ILSFINQGII TNIPRDTVLS
     DRQIVSDQTI TESNQLPKFG LKIKFNCKEI AGKTVILNGK KIRENHKIKN ILENKSQIKI
     LEKELSYDCD FILNATTCLV RIKLDNFFQI SKNGYLFYQK KLMDLTTEFK RVLVLVEYSS
     IIESTDKDIF WKLHLYLKNY QFYTYIIPSN IEEIARKISL LISRYSSKYN DNELDCNSSE
     EQILQSLNFN IFLVKDILKK FTLFDFLKGL TLNCDNRNQN ILTKQQLARI KTLLTLEW