ID   ZIP2_YEAS7              Reviewed;         704 AA.
AC   A6ZTU2;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   03-AUG-2022, entry version 37.
DE   RecName: Full=Protein ZIP2;
DE   AltName: Full=Zipping up meiotic chromosomes protein 2;
GN   Name=ZIP2; ORFNames=SCY_1825;
OS   Saccharomyces cerevisiae (strain YJM789) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=307796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YJM789;
RX   PubMed=17652520; DOI=10.1073/pnas.0701291104;
RA   Wei W., McCusker J.H., Hyman R.W., Jones T., Ning Y., Cao Z., Gu Z.,
RA   Bruno D., Miranda M., Nguyen M., Wilhelmy J., Komp C., Tamse R., Wang X.,
RA   Jia P., Luedi P., Oefner P.J., David L., Dietrich F.S., Li Y., Davis R.W.,
RA   Steinmetz L.M.;
RT   "Genome sequencing and comparative analysis of Saccharomyces cerevisiae
RT   strain YJM789.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:12825-12830(2007).
CC   -!- FUNCTION: Required for initiation of meiotic chromosome synapsis.
CC       Involved in synaptonemal complex formation, a structure that tethers a
CC       pair of homologous chromosomes along their lengths and plays a central
CC       role in recombination and homolog segregation during meiosis. Required
CC       for the normal localization of MSH4 to chromosomes (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with ZIP3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
CC       Note=Localizes to a meiosis specific chromosomal structure called the
CC       synaptonemal complex (SC) formed during meiotic prophase.
CC       {ECO:0000250}.
CC   -!- INDUCTION: During meiosis. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ZIP2 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAFW02000099; EDN61880.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6ZTU2; -.
DR   SMR; A6ZTU2; -.
DR   PRIDE; A6ZTU2; -.
DR   EnsemblFungi; EDN61880; EDN61880; SCY_1825.
DR   HOGENOM; CLU_385036_0_0_1; -.
DR   Proteomes; UP000007060; Unassembled WGS sequence.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Cell cycle; Chromosomal rearrangement; Chromosome; Chromosome partition;
KW   DNA-binding; Meiosis; Nucleotide-binding; Nucleus.
FT   CHAIN           1..704
FT                   /note="Protein ZIP2"
FT                   /id="PRO_0000333500"
SQ   SEQUENCE   704 AA;  82827 MW;  45B7B71A581E28B8 CRC64;
     MIIERWEVKL SKCNQNVGGY SVLSGNLKEN IKLGRRAQKY LKELRNLQLK PLKIGGYENC
     GTINGEEYFL EVIHITSGRQ KIDVAVGKTW NVTNIENDNK EELQYELFKE KLKVEKQDML
     FFSWMKSLSV QLNAPLHQKM TEHGLADDNT RLEWFNIPLL RRSQYRKKVP YPSLRQMSSV
     LEVQCSTLTE EKLNFCVGFS DKPLSEWKPQ IFEQTYNRYR LQRISPEKSF KYKSRCSKYN
     FKTSSQSWVV KVPEHDQQLN TFEKRSDELF DAQFNKLEFF KIRMKKLKKN KPIEKKNYKI
     WCLEKEDLKD LVWDPLKRIC NHSRYAIFEH VTINREAYSI KPLRLTFQKL DSGSLDLIDN
     QKKTFGSIKL AMSMPDVKKT ENQSIEESER HDETAIETQE FDENDCLSSK ADINTSLAPQ
     KRSFIDNELM SMLVTKKKRK KDKDVSDTGI SSTSYLINSG TYANSHIEIP TSNSVYNGKE
     DCSFNNYSVK HSILEEDIEN KCIAVNENKV IENQKVIQSL CKNSHLDLIE QSYFGECDFI
     INHSTCVYKI QASRFMQLRN NGSLHYDKAV NDLLTEFQRV IIIVEFSEII QDVDPDLFWK
     IKLYLLNSRV DVFFIHETTD FFIDWMKYFI AKWAFSYNDE KEKNIANADI LLDLGFNILL
     VRKIFQTYSL EEFFMAIIKE ESKAVKMLTV SQMTRLKKLL TLEW