ZIP3_ARATH
ID ZIP3_ARATH Reviewed; 339 AA.
AC Q9SLG3; O81125;
DT 26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Zinc transporter 3;
DE AltName: Full=ZRT/IRT-like protein 3;
DE Flags: Precursor;
GN Name=ZIP3; OrderedLocusNames=At2g32270; ORFNames=T32F6.21;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND INDUCTION.
RC STRAIN=cv. Landsberg erecta;
RX PubMed=9618566; DOI=10.1073/pnas.95.12.7220;
RA Grotz N., Fox T., Connolly E., Park W., Guerinot M.L., Eide D.;
RT "Identification of a family of zinc transporter genes from Arabidopsis that
RT respond to zinc deficiency.";
RL Proc. Natl. Acad. Sci. U.S.A. 95:7220-7224(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- FUNCTION: Mediates zinc uptake from the rhizosphere. May also transport
CC other divalent cations. {ECO:0000269|PubMed:9618566}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed predominantly in the roots of zinc-
CC deficient plants.
CC -!- INDUCTION: By zinc starvation. {ECO:0000269|PubMed:9618566}.
CC -!- MISCELLANEOUS: Zinc uptake is inhibited by copper, cobalt, cadmium,
CC iron and manganese ions.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC {ECO:0000305}.
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DR EMBL; AF033537; AAC24199.1; -; mRNA.
DR EMBL; AC005700; AAC69954.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC08660.1; -; Genomic_DNA.
DR PIR; A84731; A84731.
DR PIR; T52185; T52185.
DR RefSeq; NP_180786.1; NM_128786.4.
DR AlphaFoldDB; Q9SLG3; -.
DR SMR; Q9SLG3; -.
DR STRING; 3702.AT2G32270.1; -.
DR PaxDb; Q9SLG3; -.
DR PRIDE; Q9SLG3; -.
DR ProteomicsDB; 242950; -.
DR EnsemblPlants; AT2G32270.1; AT2G32270.1; AT2G32270.
DR GeneID; 817787; -.
DR Gramene; AT2G32270.1; AT2G32270.1; AT2G32270.
DR KEGG; ath:AT2G32270; -.
DR Araport; AT2G32270; -.
DR TAIR; locus:2062576; AT2G32270.
DR eggNOG; KOG1558; Eukaryota.
DR HOGENOM; CLU_027089_3_0_1; -.
DR InParanoid; Q9SLG3; -.
DR OMA; QYTGCHS; -.
DR OrthoDB; 981397at2759; -.
DR PhylomeDB; Q9SLG3; -.
DR PRO; PR:Q9SLG3; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9SLG3; baseline and differential.
DR Genevisible; Q9SLG3; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IDA:TAIR.
DR GO; GO:0071577; P:zinc ion transmembrane transport; IBA:GO_Central.
DR InterPro; IPR003689; ZIP.
DR InterPro; IPR004698; Zn/Fe_permease_fun/pln.
DR Pfam; PF02535; Zip; 1.
DR TIGRFAMs; TIGR00820; zip; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Ion transport; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix; Transport; Zinc; Zinc transport.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..339
FT /note="Zinc transporter 3"
FT /id="PRO_0000041641"
FT TOPO_DOM 26..54
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..86
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 108..123
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..144
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 145..184
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..205
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 206..216
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 217..237
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 238..247
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 248..268
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 269..278
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 279..299
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 300..315
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 316..336
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 337..339
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT CONFLICT 5
FT /note="N -> S (in Ref. 1; AAC24199)"
FT /evidence="ECO:0000305"
FT CONFLICT 121
FT /note="T -> I (in Ref. 1; AAC24199)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 339 AA; 36043 MW; 4698420AE78B4DEA CRC64;
MKTKNVKLLF FFFSVSLLLI AVVNAAEGHS HGGPKCECSH EDDHENKAGA RKYKIAAIPT
VLIAGIIGVL FPLLGKVFPS LRPETCFFFV TKAFAAGVIL ATGFMHVLPE AYEMLNSPCL
TSEAWEFPFT GFIAMIAAIL TLSVDTFATS SFYKSHCKAS KRVSDGETGE SSVDSEKVQI
LRTRVIAQVL ELGIIVHSVV IGISLGASQS PDAAKALFIA LMFHQCFEGL GLGGCIAQGK
FKCLSVTIMS TFFAITTPIG IVVGMGIANS YDESSPTALI VQGVLNAASA GILIYMSLVD
LLAADFTHPK MQSNTGLQIM AHIALLLGAG LMSLLAKWA
