ZIP3_CAEEL
ID ZIP3_CAEEL Reviewed; 307 AA.
AC Q9XUK2;
DT 07-APR-2021, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2004, sequence version 2.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Transcription factor zip-3 {ECO:0000305};
DE AltName: Full=BZIP transcription factor family zip-3 {ECO:0000312|WormBase:W07G1.3};
GN Name=zip-3 {ECO:0000312|WormBase:W07G1.3};
GN ORFNames=W07G1.3 {ECO:0000312|WormBase:W07G1.3};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, AND MUTAGENESIS OF TYR-167.
RX PubMed=30850535; DOI=10.1073/pnas.1817259116;
RA Deng P., Uma Naresh N., Du Y., Lamech L.T., Yu J., Zhu L.J.,
RA Pukkila-Worley R., Haynes C.M.;
RT "Mitochondrial UPR repression during Pseudomonas aeruginosa infection
RT requires the bZIP protein ZIP-3.";
RL Proc. Natl. Acad. Sci. U.S.A. 116:6146-6151(2019).
CC -!- FUNCTION: Transcription factor which negatively modulates activation of
CC the mitochondrial unfolded protein response (mtUPR) (PubMed:30850535).
CC Plays a role in response to infection by the Gram-negative bacterium
CC P.aeruginosa (PubMed:30850535). {ECO:0000269|PubMed:30850535}.
CC -!- INTERACTION:
CC Q9XUK2; Q8IG69: cebp-2; NbExp=3; IntAct=EBI-322774, EBI-2914231;
CC Q9XUK2; Q94126: ces-2; NbExp=2; IntAct=EBI-322774, EBI-328155;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978,
CC ECO:0000269|PubMed:30850535}.
CC -!- SIMILARITY: Belongs to the bZIP family. {ECO:0000305}.
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DR EMBL; BX284602; CAB04935.2; -; Genomic_DNA.
DR PIR; T26267; T26267.
DR RefSeq; NP_496919.2; NM_064518.4.
DR AlphaFoldDB; Q9XUK2; -.
DR SMR; Q9XUK2; -.
DR DIP; DIP-26962N; -.
DR IntAct; Q9XUK2; 9.
DR STRING; 6239.W07G1.3.1; -.
DR EPD; Q9XUK2; -.
DR PaxDb; Q9XUK2; -.
DR EnsemblMetazoa; W07G1.3.1; W07G1.3.1; WBGene00012330.
DR EnsemblMetazoa; W07G1.3.2; W07G1.3.2; WBGene00012330.
DR GeneID; 189280; -.
DR KEGG; cel:CELE_W07G1.3; -.
DR UCSC; W07G1.3; c. elegans.
DR CTD; 189280; -.
DR WormBase; W07G1.3; CE37052; WBGene00012330; zip-3.
DR eggNOG; KOG4571; Eukaryota.
DR HOGENOM; CLU_869402_0_0_1; -.
DR InParanoid; Q9XUK2; -.
DR OMA; DADDFMR; -.
DR OrthoDB; 1888233at2759; -.
DR SignaLink; Q9XUK2; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00012330; Expressed in larva and 4 other tissues.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0034514; P:mitochondrial unfolded protein response; IMP:UniProtKB.
DR GO; GO:0045824; P:negative regulation of innate immune response; IMP:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR046347; bZIP_sf.
DR Pfam; PF07716; bZIP_2; 1.
DR SMART; SM00338; BRLZ; 1.
DR SUPFAM; SSF57959; SSF57959; 1.
DR PROSITE; PS50217; BZIP; 1.
DR PROSITE; PS00036; BZIP_BASIC; 1.
PE 1: Evidence at protein level;
KW Coiled coil; DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..307
FT /note="Transcription factor zip-3"
FT /id="PRO_0000452494"
FT DOMAIN 243..304
FT /note="bZIP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 24..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 247..268
FT /note="Basic motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 259..286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 278..285
FT /note="Leucine-zipper"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT COMPBIAS 29..43
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MUTAGEN 167
FT /note="Y->A: Mutant protein accumulates in the intestinal
FT nuclei and inhibits the mitochondrial unfolded protein
FT response (mtUPR) on an atfs-1 mutant background, or in
FT response to phenazines."
FT /evidence="ECO:0000269|PubMed:30850535"
SQ SEQUENCE 307 AA; 34752 MW; 51DBDA150FA15015 CRC64;
MQPSYDADDF MRRGFFGSFI GFRKRSSSKP EPPVPPKFAP PAAPSVAPNF RASDSAAPHL
LSVPSNRTEY DIYREIVSEA EYIERSSPAS PDFSCPTTPQ PSNYYTPLPL PQQPPTFDPS
TLMPQQQMMF HPGQYHMVMS PIAPHPIPVD TNGVPLGTQC PMAPPPYSSF APQSSSSGML
QQQPQDLVIP QDIPFDVKRE IQEHLVLQNG KKQMSIEEIV KLVVVALKDS QIEEGREEEE
SPEEILRRKR IQNNLAAARY RKRQREARES AESELGDLTR RNDELRDQVS RMEREIDRLK
QAVLGRQ
